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Items: 1 to 20 of 96

1.

Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network.

Kang BH, Plescia J, Dohi T, Rosa J, Doxsey SJ, Altieri DC.

Cell. 2007 Oct 19;131(2):257-70.

2.

Hsp90 inhibitors, GA and 17AAG, lead to ER stress-induced apoptosis in rat histiocytoma.

Taiyab A, Sreedhar AS, Rao ChM.

Biochem Pharmacol. 2009 Jul 15;78(2):142-52. doi: 10.1016/j.bcp.2009.04.001. Epub 2009 Apr 9.

PMID:
19464431
3.

Inhibition of the mitochondrial Hsp90 chaperone network: a novel, efficient treatment strategy for cancer?

Siegelin MD.

Cancer Lett. 2013 Jun 10;333(2):133-46. doi: 10.1016/j.canlet.2013.01.045. Epub 2013 Jan 31. Review.

PMID:
23376257
4.

Altered Hsp90 function in cancer: a unique therapeutic opportunity.

Bagatell R, Whitesell L.

Mol Cancer Ther. 2004 Aug;3(8):1021-30. Review.

5.

Rational design of shepherdin, a novel anticancer agent.

Plescia J, Salz W, Xia F, Pennati M, Zaffaroni N, Daidone MG, Meli M, Dohi T, Fortugno P, Nefedova Y, Gabrilovich DI, Colombo G, Altieri DC.

Cancer Cell. 2005 May;7(5):457-68.

6.

Antileukemic activity of shepherdin and molecular diversity of hsp90 inhibitors.

Gyurkocza B, Plescia J, Raskett CM, Garlick DS, Lowry PA, Carter BZ, Andreeff M, Meli M, Colombo G, Altieri DC.

J Natl Cancer Inst. 2006 Aug 2;98(15):1068-77.

PMID:
16882944
7.

Indirect participation of Hsp90 in the regulation of the cyclin E turnover.

Bedin M, Catelli MG, CabaniƩ L, Gaben AM, Mester J.

Biochem Pharmacol. 2009 Jan 15;77(2):151-8. doi: 10.1016/j.bcp.2008.09.038. Epub 2008 Oct 14.

PMID:
18977205
8.

Drug-mediated targeted disruption of multiple protein activities through functional inhibition of the Hsp90 chaperone complex.

Stravopodis DJ, Margaritis LH, Voutsinas GE.

Curr Med Chem. 2007;14(29):3122-38. Review.

PMID:
18220746
9.

Hsp90 inhibitors disrupt mitochondrial homeostasis in cancer cells.

Neckers L, Kern A, Tsutsumi S.

Chem Biol. 2007 Nov;14(11):1204-6.

10.

Heat shock protein 90beta1 is essential for polyunsaturated fatty acid-induced mitochondrial Ca2+ efflux.

Zhang H, Li ZH, Zhang MQ, Katz MS, Zhang BX.

J Biol Chem. 2008 Mar 21;283(12):7580-9. doi: 10.1074/jbc.M707192200. Epub 2008 Jan 3.

11.

Hsp90 regulates the Fanconi anemia DNA damage response pathway.

Oda T, Hayano T, Miyaso H, Takahashi N, Yamashita T.

Blood. 2007 Jun 1;109(11):5016-26. Epub 2007 Feb 27.

12.
13.

Tubocapsenolide A, a novel withanolide, inhibits proliferation and induces apoptosis in MDA-MB-231 cells by thiol oxidation of heat shock proteins.

Chen WY, Chang FR, Huang ZY, Chen JH, Wu YC, Wu CC.

J Biol Chem. 2008 Jun 20;283(25):17184-93. doi: 10.1074/jbc.M709447200. Epub 2008 Apr 28.

14.

Hsp90: a chaperone for protein folding and gene regulation.

Zhao R, Houry WA.

Biochem Cell Biol. 2005 Dec;83(6):703-10. Review.

PMID:
16333321
15.

BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90.

Lundgren K, Zhang H, Brekken J, Huser N, Powell RE, Timple N, Busch DJ, Neely L, Sensintaffar JL, Yang YC, McKenzie A, Friedman J, Scannevin R, Kamal A, Hong K, Kasibhatla SR, Boehm MF, Burrows FJ.

Mol Cancer Ther. 2009 Apr;8(4):921-9. doi: 10.1158/1535-7163.MCT-08-0758.

16.

Molecular chaperones and protein kinase quality control.

Caplan AJ, Mandal AK, Theodoraki MA.

Trends Cell Biol. 2007 Feb;17(2):87-92. Epub 2006 Dec 20. Review.

PMID:
17184992
17.

HSP90 inhibitor 17AAG causes apoptosis in ATRA-resistant acute promyelocytic leukemia cells.

Meyer PN, Roychowdhury S, Kini AR, Alkan S.

Leuk Res. 2008 Jan;32(1):143-9. Epub 2007 Jul 6.

PMID:
17617451
18.

[Study on signal transduction pathway in differentiation and apoptosis of leukemia cells induced by heat shock protein inhibitor].

Yu WJ, Rao Q, Wang M, Tian Z, Xu ZF, Wang JX.

Zhonghua Xue Ye Xue Za Zhi. 2007 Oct;28(10):677-80. Chinese.

PMID:
18399173
20.

Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites.

Lee K, Ryu JS, Jin Y, Kim W, Kaur N, Chung SJ, Jeon YJ, Park JT, Bang JS, Lee HS, Kim TY, Lee JJ, Hong YS.

Org Biomol Chem. 2008 Jan 21;6(2):340-8. doi: 10.1039/b713407j. Epub 2007 Nov 30.

PMID:
18175003

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