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Augmentation of anti-tumor responses of adoptively transferred CD8+T cells in the lymphopenic setting by HSV amplicon transduction.

Nechushtan H, Pham D, Zhang Y, Morgensztern D, Yi KH, Shin SU, Federoff HJ, Bowers WJ, Tolba KA, Rosenblatt JD.

Cancer Immunol Immunother. 2008 May;57(5):663-75. Epub 2007 Oct 19.


Adoptively transferred tumor-specific T cells stimulated ex vivo using herpes simplex virus amplicons encoding 4-1BBL persist in the host and show antitumor activity in vivo.

Yi KH, Nechushtan H, Bowers WJ, Walker GR, Zhang Y, Pham DG, Podack ER, Federoff HJ, Tolba KA, Rosenblatt JD.

Cancer Res. 2007 Oct 15;67(20):10027-37.


[New strategy of cancer immunotherapy: irradiation or chemotherapeutics-induced lymphopenia combined with immune reconstitution and tumor vaccine].

Ma J, Wang YL, Hu HM, Fox BA, Si LS.

Zhonghua Zhong Liu Za Zhi. 2005 Aug;27(8):452-6. Chinese.


Herpes simplex virus (HSV) amplicon-mediated codelivery of secondary lymphoid tissue chemokine and CD40L results in augmented antitumor activity.

Tolba KA, Bowers WJ, Muller J, Housekneckt V, Giuliano RE, Federoff HJ, Rosenblatt JD.

Cancer Res. 2002 Nov 15;62(22):6545-51.


Glucocorticoid-induced tumor necrosis factor receptor stimulation enhances the multifunctionality of adoptively transferred tumor antigen-specific CD8+ T cells with tumor regression.

Imai N, Ikeda H, Tawara I, Wang L, Wang L, Nishikawa H, Kato T, Shiku H.

Cancer Sci. 2009 Jul;100(7):1317-25. doi: 10.1111/j.1349-7006.2009.01179.x. Epub 2009 Apr 29.


IFN-gamma inhibits IL-4-induced type 2 cytokine expression by CD8 T cells in vivo and modulates the anti-tumor response.

Apte SH, Groves P, Olver S, Baz A, Doolan DL, Kelso A, Kienzle N.

J Immunol. 2010 Jul 15;185(2):998-1004. doi: 10.4049/jimmunol.0903372. Epub 2010 Jun 18.


Activation and route of administration both determine the ability of bone marrow-derived dendritic cells to accumulate in secondary lymphoid organs and prime CD8+ T cells against tumors.

Huck SP, Tang SC, Andrew KA, Yang J, Harper JL, Ronchese F.

Cancer Immunol Immunother. 2008 Jan;57(1):63-71. Epub 2007 Jul 3.


Combined CD4+ Th1 effect and lymphotactin transgene expression enhance CD8+ Tc1 tumor localization and therapy.

Huang H, Bi XG, Yuan JY, Xu SL, Guo XL, Xiang J.

Gene Ther. 2005 Jun;12(12):999-1010.


Accumulation in tumor tissue of adoptively transferred T cells: A comparison between intravenous and intraperitoneal injection.

Petersen CC, Petersen MS, Agger R, Hokland ME.

J Immunother. 2006 May-Jun;29(3):241-9.


CD8+ T cells induce complete regression of advanced ovarian cancers by an interleukin (IL)-2/IL-15 dependent mechanism.

Yang T, Wall EM, Milne K, Theiss P, Watson P, Nelson BH.

Clin Cancer Res. 2007 Dec 1;13(23):7172-80.


Generation of anti-tumour effector T cells from naïve T cells by stimulation with dendritic/tumour fusion cells.

Ishida A, Tanaka H, Hiura T, Miura S, Watanabe S, Matsuyama K, Kuriyama H, Tanaka J, Kagamu H, Gejyo F, Yoshizawa H.

Scand J Immunol. 2007 Nov;66(5):546-54.


Bryostatin 1/ionomycin (B/I) ex vivo stimulation preferentially activates L-selectinlow tumor-sensitized lymphocytes.

Chin CS, Miller CH, Graham L, Parviz M, Zacur S, Patel B, Duong A, Bear HD.

Int Immunol. 2004 Sep;16(9):1283-94. Epub 2004 Jul 19.


The CD8 T cell response to vaccinia virus exhibits site-dependent heterogeneity of functional responses.

Xiao Z, Curtsinger JM, Prlic M, Jameson SC, Mescher MF.

Int Immunol. 2007 Jun;19(6):733-43. Epub 2007 Jun 1.


Homeostatic proliferation as an isolated variable reverses CD8+ T cell anergy and promotes tumor rejection.

Brown IE, Blank C, Kline J, Kacha AK, Gajewski TF.

J Immunol. 2006 Oct 1;177(7):4521-9.


Adoptive transfer of type 1 CTL mediates effective anti-central nervous system tumor response: critical roles of IFN-inducible protein-10.

Nishimura F, Dusak JE, Eguchi J, Zhu X, Gambotto A, Storkus WJ, Okada H.

Cancer Res. 2006 Apr 15;66(8):4478-87.


Cyclophosphamide enhances the antitumor efficacy of adoptively transferred immune cells through the induction of cytokine expression, B-cell and T-cell homeostatic proliferation, and specific tumor infiltration.

Bracci L, Moschella F, Sestili P, La Sorsa V, Valentini M, Canini I, Baccarini S, Maccari S, Ramoni C, Belardelli F, Proietti E.

Clin Cancer Res. 2007 Jan 15;13(2 Pt 1):644-53.

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