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Items: 1 to 20 of 104

1.

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.

Rasmussen SG, Choi HJ, Rosenbaum DM, Kobilka TS, Thian FS, Edwards PC, Burghammer M, Ratnala VR, Sanishvili R, Fischetti RF, Schertler GF, Weis WI, Kobilka BK.

Nature. 2007 Nov 15;450(7168):383-7. Epub 2007 Oct 21.

PMID:
17952055
2.

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function.

Rosenbaum DM, Cherezov V, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Yao XJ, Weis WI, Stevens RC, Kobilka BK.

Science. 2007 Nov 23;318(5854):1266-73. Epub 2007 Oct 25.

3.

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.

Cherezov V, Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Kuhn P, Weis WI, Kobilka BK, Stevens RC.

Science. 2007 Nov 23;318(5854):1258-65. Epub 2007 Oct 25.

4.

Structural features of β2 adrenergic receptor: crystal structures and beyond.

Bang I, Choi HJ.

Mol Cells. 2015;38(2):105-11. doi: 10.14348/molcells.2015.2301. Epub 2014 Dec 24. Review.

5.

Structural biology: a receptor unlocked.

Sprang SR.

Nature. 2007 Nov 15;450(7168):355-6. No abstract available.

PMID:
18004367
6.

Agonist-induced conformational changes in bovine rhodopsin: insight into activation of G-protein-coupled receptors.

Bhattacharya S, Hall SE, Vaidehi N.

J Mol Biol. 2008 Oct 3;382(2):539-55. doi: 10.1016/j.jmb.2008.06.084. Epub 2008 Jul 7.

PMID:
18638482
7.

The role of protein dynamics in GPCR function: insights from the β2AR and rhodopsin.

Manglik A, Kobilka B.

Curr Opin Cell Biol. 2014 Apr;27:136-43. doi: 10.1016/j.ceb.2014.01.008. Epub 2014 Feb 17. Review.

8.

Structure and function of an irreversible agonist-β(2) adrenoceptor complex.

Rosenbaum DM, Zhang C, Lyons JA, Holl R, Aragao D, Arlow DH, Rasmussen SG, Choi HJ, Devree BT, Sunahara RK, Chae PS, Gellman SH, Dror RO, Shaw DE, Weis WI, Caffrey M, Gmeiner P, Kobilka BK.

Nature. 2011 Jan 13;469(7329):236-40. doi: 10.1038/nature09665.

9.

Modeling the possible conformations of the extracellular loops in G-protein-coupled receptors.

Nikiforovich GV, Taylor CM, Marshall GR, Baranski TJ.

Proteins. 2010 Feb 1;78(2):271-85. doi: 10.1002/prot.22537.

10.

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor.

Rasmussen SG, Choi HJ, Fung JJ, Pardon E, Casarosa P, Chae PS, Devree BT, Rosenbaum DM, Thian FS, Kobilka TS, Schnapp A, Konetzki I, Sunahara RK, Gellman SH, Pautsch A, Steyaert J, Weis WI, Kobilka BK.

Nature. 2011 Jan 13;469(7329):175-80. doi: 10.1038/nature09648.

11.

Crystallizing thinking about the beta2-adrenergic receptor.

Shukla AK, Sun JP, Lefkowitz RJ.

Mol Pharmacol. 2008 May;73(5):1333-8. doi: 10.1124/mol.108.045849. Epub 2008 Jan 31.

12.

Crystallization of G protein-coupled receptors.

Salom D, Padayatti PS, Palczewski K.

Methods Cell Biol. 2013;117:451-68. doi: 10.1016/B978-0-12-408143-7.00024-4.

13.

Active state-like conformational elements in the beta2-AR and a photoactivated intermediate of rhodopsin identified by dynamic properties of GPCRs.

Han DS, Wang SX, Weinstein H.

Biochemistry. 2008 Jul 15;47(28):7317-21. doi: 10.1021/bi800442g. Epub 2008 Jun 18.

14.

Identifying conformational changes of the beta(2) adrenoceptor that enable accurate prediction of ligand/receptor interactions and screening for GPCR modulators.

Reynolds KA, Katritch V, Abagyan R.

J Comput Aided Mol Des. 2009 May;23(5):273-88. doi: 10.1007/s10822-008-9257-9. Epub 2009 Jan 16.

15.

Do crystal structures obviate the need for theoretical models of GPCRs for structure-based virtual screening?

Tang H, Wang XS, Hsieh JH, Tropsha A.

Proteins. 2012 Jun;80(6):1503-21. doi: 10.1002/prot.24035. Epub 2012 Mar 13.

16.
17.

Dynamic behavior of fully solvated beta2-adrenergic receptor, embedded in the membrane with bound agonist or antagonist.

Spijker P, Vaidehi N, Freddolino PL, Hilbers PA, Goddard WA 3rd.

Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):4882-7. Epub 2006 Mar 21.

18.

Light-driven activation of beta 2-adrenergic receptor signaling by a chimeric rhodopsin containing the beta 2-adrenergic receptor cytoplasmic loops.

Kim JM, Hwa J, Garriga P, Reeves PJ, RajBhandary UL, Khorana HG.

Biochemistry. 2005 Feb 22;44(7):2284-92.

PMID:
15709741
19.

Toward the active conformations of rhodopsin and the beta2-adrenergic receptor.

Gouldson PR, Kidley NJ, Bywater RP, Psaroudakis G, Brooks HD, Diaz C, Shire D, Reynolds CA.

Proteins. 2004 Jul 1;56(1):67-84.

PMID:
15162487
20.

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor.

Bokoch MP, Zou Y, Rasmussen SG, Liu CW, Nygaard R, Rosenbaum DM, Fung JJ, Choi HJ, Thian FS, Kobilka TS, Puglisi JD, Weis WI, Pardo L, Prosser RS, Mueller L, Kobilka BK.

Nature. 2010 Jan 7;463(7277):108-12. doi: 10.1038/nature08650.

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