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Items: 1 to 20 of 66

1.

Targeting focal adhesion kinase with small interfering RNA prevents and reverses load-induced cardiac hypertrophy in mice.

Clemente CF, Tornatore TF, Theizen TH, Deckmann AC, Pereira TC, Lopes-Cendes I, Souza JR, Franchini KG.

Circ Res. 2007 Dec 7;101(12):1339-48. Epub 2007 Oct 18.

2.

Small interfering RNA targeting focal adhesion kinase prevents cardiac dysfunction in endotoxemia.

Guido MC, Clemente CF, Moretti AI, Barbeiro HV, Debbas V, Caldini EG, Franchini KG, Soriano FG.

Shock. 2012 Jan;37(1):77-84. doi: 10.1097/SHK.0b013e31823532ec.

PMID:
21921830
3.

PYK2 expression and phosphorylation increases in pressure overload-induced left ventricular hypertrophy.

Bayer AL, Heidkamp MC, Patel N, Porter MJ, Engman SJ, Samarel AM.

Am J Physiol Heart Circ Physiol. 2002 Aug;283(2):H695-706.

4.

Shp2 negatively regulates growth in cardiomyocytes by controlling focal adhesion kinase/Src and mTOR pathways.

Marin TM, Clemente CF, Santos AM, Picardi PK, Pascoal VD, Lopes-Cendes I, Saad MJ, Franchini KG.

Circ Res. 2008 Oct 10;103(8):813-24. doi: 10.1161/CIRCRESAHA.108.179754. Epub 2008 Aug 28.

5.

MEF2C silencing attenuates load-induced left ventricular hypertrophy by modulating mTOR/S6K pathway in mice.

Pereira AH, Clemente CF, Cardoso AC, Theizen TH, Rocco SA, Judice CC, Guido MC, Pascoal VD, Lopes-Cendes I, Souza JR, Franchini KG.

PLoS One. 2009 Dec 29;4(12):e8472. doi: 10.1371/journal.pone.0008472. Erratum in: PLoS One. 2014;9(10):e112344.

6.

Matrix metalloproteinase-2 stimulates collagen-I expression through phosphorylation of focal adhesion kinase in rat cardiac fibroblasts.

Hori Y, Kashimoto T, Yonezawa T, Sano N, Saitoh R, Igarashi S, Chikazawa S, Kanai K, Hoshi F, Itoh N, Higuchi S.

Am J Physiol Cell Physiol. 2012 Nov 1;303(9):C947-53. doi: 10.1152/ajpcell.00401.2011. Epub 2012 Aug 22.

7.

Targeting to C-terminal myosin heavy chain may explain mechanotransduction involving focal adhesion kinase in cardiac myocytes.

Fonseca PM, Inoue RY, Kobarg CB, Crosara-Alberto DP, Kobarg J, Franchini KG.

Circ Res. 2005 Jan 7;96(1):73-81. Epub 2004 Dec 2.

8.

Focal adhesion kinase governs cardiac concentric hypertrophic growth by activating the AKT and mTOR pathways.

Clemente CF, Xavier-Neto J, Dalla Costa AP, Consonni SR, Antunes JE, Rocco SA, Pereira MB, Judice CC, Strauss B, Joazeiro PP, Matos-Souza JR, Franchini KG.

J Mol Cell Cardiol. 2012 Feb;52(2):493-501. doi: 10.1016/j.yjmcc.2011.10.015. Epub 2011 Oct 26.

PMID:
22056317
9.

Mitogen-activated protein kinases (p38 and c-Jun NH2-terminal kinase) are differentially regulated during cardiac volume and pressure overload hypertrophy.

Sopontammarak S, Aliharoob A, Ocampo C, Arcilla RA, Gupta MP, Gupta M.

Cell Biochem Biophys. 2005;43(1):61-76.

PMID:
16043884
10.
11.

Endothelin-induced cardiac myocyte hypertrophy: role for focal adhesion kinase.

Eble DM, Strait JB, Govindarajan G, Lou J, Byron KL, Samarel AM.

Am J Physiol Heart Circ Physiol. 2000 May;278(5):H1695-707.

12.

Striated muscle-specific beta(1D)-integrin and FAK are involved in cardiac myocyte hypertrophic response pathway.

Pham CG, Harpf AE, Keller RS, Vu HT, Shai SY, Loftus JC, Ross RS.

Am J Physiol Heart Circ Physiol. 2000 Dec;279(6):H2916-26.

13.

Increased expression and phosphorylation of focal adhesion kinase correlates with dysfunction in the volume-overloaded human heart.

Lopes MM, Ribeiro GC, Tornatore TF, Clemente CF, Teixeira VP, Franchini KG.

Clin Sci (Lond). 2007 Aug;113(4):195-204.

PMID:
17497960
14.

B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading.

Tse KW, Dang-Lawson M, Lee RL, Vong D, Bulic A, Buckbinder L, Gold MR.

J Biol Chem. 2009 Aug 21;284(34):22865-77. doi: 10.1074/jbc.M109.013169. Epub 2009 Jun 26.

15.

Focal adhesion kinase is activated and mediates the early hypertrophic response to stretch in cardiac myocytes.

Torsoni AS, Constancio SS, Nadruz W Jr, Hanks SK, Franchini KG.

Circ Res. 2003 Jul 25;93(2):140-7. Epub 2003 Jun 12.

16.

FAK, PIP5KIgamma and gelsolin cooperatively mediate force-induced expression of alpha-smooth muscle actin.

Chan MW, Arora PD, Bozavikov P, McCulloch CA.

J Cell Sci. 2009 Aug 1;122(Pt 15):2769-81. doi: 10.1242/jcs.044008. Epub 2009 Jul 13.

17.

Genetic enhancement of ventricular contractility protects against pressure-overload-induced cardiac dysfunction.

Du XJ, Fang L, Gao XM, Kiriazis H, Feng X, Hotchkin E, Finch AM, Chaulet H, Graham RM.

J Mol Cell Cardiol. 2004 Nov;37(5):979-87.

PMID:
15522275
18.

Knockdown of focal adhesion kinase reverses colon carcinoma multicellular resistance.

Chen YY, Wang ZX, Chang PA, Li JJ, Pan F, Yang L, Bian ZH, Zou L, He JM, Liang HJ.

Cancer Sci. 2009 Sep;100(9):1708-13. doi: 10.1111/j.1349-7006.2009.01217.x. Epub 2009 May 12.

19.

Myocyte-restricted focal adhesion kinase deletion attenuates pressure overload-induced hypertrophy.

DiMichele LA, Doherty JT, Rojas M, Beggs HE, Reichardt LF, Mack CP, Taylor JM.

Circ Res. 2006 Sep 15;99(6):636-45. Epub 2006 Aug 10.

20.

A role for focal adhesion kinase in phenylephrine-induced hypertrophy of rat ventricular cardiomyocytes.

Taylor JM, Rovin JD, Parsons JT.

J Biol Chem. 2000 Jun 23;275(25):19250-7.

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