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A positive role of mammalian Tip41-like protein, TIPRL, in the amino-acid dependent mTORC1-signaling pathway through interaction with PP2A.

Nakashima A, Tanimura-Ito K, Oshiro N, Eguchi S, Miyamoto T, Momonami A, Kamada S, Yonezawa K, Kikkawa U.

FEBS Lett. 2013 Sep 17;587(18):2924-9. doi: 10.1016/j.febslet.2013.07.027. Epub 2013 Jul 24.


Parallel purification of three catalytic subunits of the protein serine/threonine phosphatase 2A family (PP2A(C), PP4(C), and PP6(C)) and analysis of the interaction of PP2A(C) with alpha4 protein.

Kloeker S, Reed R, McConnell JL, Chang D, Tran K, Westphal RS, Law BK, Colbran RJ, Kamoun M, Campbell KS, Wadzinski BE.

Protein Expr Purif. 2003 Sep;31(1):19-33.


The structure of Tap42/alpha4 reveals a tetratricopeptide repeat-like fold and provides insights into PP2A regulation.

Yang J, Roe SM, Prickett TD, Brautigan DL, Barford D.

Biochemistry. 2007 Jul 31;46(30):8807-15. Epub 2007 Jul 6.


Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway.

McConnell JL, Gomez RJ, McCorvey LR, Law BK, Wadzinski BE.

Oncogene. 2007 Sep 6;26(41):6021-30. Epub 2007 Mar 26.


Inhibition of MKK7-JNK by the TOR signaling pathway regulator-like protein contributes to resistance of HCC cells to TRAIL-induced apoptosis.

Song IS, Jun SY, Na HJ, Kim HT, Jung SY, Ha GH, Park YH, Long LZ, Yu DY, Kim JM, Kim JH, Ko JH, Kim CH, Kim NS.

Gastroenterology. 2012 Nov;143(5):1341-51. doi: 10.1053/j.gastro.2012.07.103. Epub 2012 Jul 27.


Regulation of protein phosphatase 2A catalytic activity by alpha4 protein and its yeast homolog Tap42.

Nanahoshi M, Nishiuma T, Tsujishita Y, Hara K, Inui S, Sakaguchi N, Yonezawa K.

Biochem Biophys Res Commun. 1998 Oct 20;251(2):520-6.


The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation.

LeNoue-Newton M, Watkins GR, Zou P, Germane KL, McCorvey LR, Wadzinski BE, Spiller BW.

J Biol Chem. 2011 May 20;286(20):17665-71. doi: 10.1074/jbc.M111.222414. Epub 2011 Mar 29.


Specific interactions of PP2A and PP2A-like phosphatases with the yeast PTPA homologues, Ypa1 and Ypa2.

Van Hoof C, Martens E, Longin S, Jordens J, Stevens I, Janssens V, Goris J.

Biochem J. 2005 Feb 15;386(Pt 1):93-102.


alpha4 phosphoprotein interacts with EDD E3 ubiquitin ligase and poly(A)-binding protein.

McDonald WJ, Sangster SM, Moffat LD, Henderson MJ, Too CK.

J Cell Biochem. 2010 Aug 1;110(5):1123-9. doi: 10.1002/jcb.22624.


Fission yeast homologues of the B' subunit of protein phosphatase 2A: multiple roles in mitotic cell division and functional interaction with calcineurin.

Tanabe O, Hirata D, Usui H, Nishito Y, Miyakawa T, Igarashi K, Takeda M.

Genes Cells. 2001 May;6(5):455-73.


Overlapping binding sites in protein phosphatase 2A for association with regulatory A and alpha-4 (mTap42) subunits.

Prickett TD, Brautigan DL.

J Biol Chem. 2004 Sep 10;279(37):38912-20. Epub 2004 Jul 13.


The heterodimer of alpha4 and PP2Ac is associated with S6 kinase1 in B cells.

Yamashita T, Inui S, Maeda K, Hua DR, Takagi K, Sakaguchi N.

Biochem Biophys Res Commun. 2005 May 6;330(2):439-45.


MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac.

Du H, Wu K, Didoronkute A, Levy MV, Todi N, Shchelokova A, Massiah MA.

PLoS One. 2014 Sep 10;9(9):e107428. doi: 10.1371/journal.pone.0107428. eCollection 2014.


Alpha4 protein as a common regulator of type 2A-related serine/threonine protein phosphatases.

Nanahoshi M, Tsujishita Y, Tokunaga C, Inui S, Sakaguchi N, Hara K, Yonezawa K.

FEBS Lett. 1999 Mar 5;446(1):108-12.


Crystal structure of the human Tip41 orthologue, TIPRL, reveals a novel fold and a binding site for the PP2Ac C-terminus.

Scorsato V, Lima TB, Righetto GL, Zanchin NI, Brandão-Neto J, Sandy J, Pereira HD, Ferrari ÁJ, Gozzo FC, Smetana JH, Aparicio R.

Sci Rep. 2016 Aug 4;6:30813. doi: 10.1038/srep30813.


Alpha4 is a ubiquitin-binding protein that regulates protein serine/threonine phosphatase 2A ubiquitination.

McConnell JL, Watkins GR, Soss SE, Franz HS, McCorvey LR, Spiller BW, Chazin WJ, Wadzinski BE.

Biochemistry. 2010 Mar 2;49(8):1713-8. doi: 10.1021/bi901837h.

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