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The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation.

Shembade N, Harhaj NS, Yamamoto M, Akira S, Harhaj EW.

J Virol. 2007 Dec;81(24):13735-42. Epub 2007 Oct 17.


Regulation of HTLV-1 tax stability, cellular trafficking and NF-κB activation by the ubiquitin-proteasome pathway.

Lavorgna A, Harhaj EW.

Viruses. 2014 Oct 23;6(10):3925-43. doi: 10.3390/v6103925. Review.


Exclusive ubiquitination and sumoylation on overlapping lysine residues mediate NF-kappaB activation by the human T-cell leukemia virus tax oncoprotein.

Lamsoul I, Lodewick J, Lebrun S, Brasseur R, Burny A, Gaynor RB, Bex F.

Mol Cell Biol. 2005 Dec;25(23):10391-406.


A non-SUMOylated tax protein is still functional for NF-κB pathway activation.

Pène S, Waast L, Bonnet A, Bénit L, Pique C.

J Virol. 2014 Sep;88(18):10655-61. doi: 10.1128/JVI.01827-14. Epub 2014 Jul 2.


Human T cell leukemia virus type 2 tax-mediated NF-κB activation involves a mechanism independent of Tax conjugation to ubiquitin and SUMO.

Journo C, Bonnet A, Favre-Bonvin A, Turpin J, Vinera J, Côté E, Chevalier SA, Kfoury Y, Bazarbachi A, Pique C, Mahieux R.

J Virol. 2013 Jan;87(2):1123-36. doi: 10.1128/JVI.01792-12. Epub 2012 Nov 7.


Tax ubiquitylation and SUMOylation control the dynamic shuttling of Tax and NEMO between Ubc9 nuclear bodies and the centrosome.

Kfoury Y, Setterblad N, El-Sabban M, Zamborlini A, Dassouki Z, El Hajj H, Hermine O, Pique C, de Thé H, Saïb A, Bazarbachi A.

Blood. 2011 Jan 6;117(1):190-9. doi: 10.1182/blood-2010-05-285742. Epub 2010 Oct 19.


Low nuclear body formation and tax SUMOylation do not prevent NF-kappaB promoter activation.

Bonnet A, Randrianarison-Huetz V, Nzounza P, Nedelec M, Chazal M, Waast L, Pene S, Bazarbachi A, Mahieux R, Bénit L, Pique C.

Retrovirology. 2012 Sep 25;9:77. doi: 10.1186/1742-4690-9-77.


HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation.

Ho YK, Zhi H, Bowlin T, Dorjbal B, Philip S, Zahoor MA, Shih HM, Semmes OJ, Schaefer B, Glover JN, Giam CZ.

PLoS Pathog. 2015 Aug 18;11(8):e1005102. doi: 10.1371/journal.ppat.1005102. eCollection 2015 Aug.


Human T-cell leukemia virus type 1 (HTLV-1) tax requires CADM1/TSLC1 for inactivation of the NF-κB inhibitor A20 and constitutive NF-κB signaling.

Pujari R, Hunte R, Thomas R, van der Weyden L, Rauch D, Ratner L, Nyborg JK, Ramos JC, Takai Y, Shembade N.

PLoS Pathog. 2015 Mar 16;11(3):e1004721. doi: 10.1371/journal.ppat.1004721. eCollection 2015 Mar.


HTLV-1 tax-induced rapid senescence is driven by the transcriptional activity of NF-κB and depends on chronically activated IKKα and p65/RelA.

Ho YK, Zhi H, DeBiaso D, Philip S, Shih HM, Giam CZ.

J Virol. 2012 Sep;86(17):9474-83. doi: 10.1128/JVI.00158-12. Epub 2012 Jun 27.


An RNA interference screen identifies the Deubiquitinase STAMBPL1 as a critical regulator of human T-cell leukemia virus type 1 tax nuclear export and NF-κB activation.

Lavorgna A, Harhaj EW.

J Virol. 2012 Mar;86(6):3357-69. doi: 10.1128/JVI.06456-11. Epub 2012 Jan 18. Erratum in: J Virol. 2012 May;86(9):5409.


Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO.

Zhou H, Wertz I, O'Rourke K, Ultsch M, Seshagiri S, Eby M, Xiao W, Dixit VM.

Nature. 2004 Jan 8;427(6970):167-71. Epub 2003 Dec 24.


Activation of the IκB kinase complex by HTLV-1 Tax requires cytosolic factors involved in Tax-induced polyubiquitination.

Shibata Y, Tanaka Y, Gohda J, Inoue J.

J Biochem. 2011 Dec;150(6):679-86. doi: 10.1093/jb/mvr106. Epub 2011 Aug 23.


Tax deregulation of NF-kappaB2 p100 processing involves both beta-TrCP-dependent and -independent mechanisms.

Qu Z, Qing G, Rabson A, Xiao G.

J Biol Chem. 2004 Oct 22;279(43):44563-72. Epub 2004 Aug 13.


Ubiquitination and sumoylation of the HTLV-2 Tax-2B protein regulate its NF-κB activity: a comparative study with the HTLV-1 Tax-1 protein.

Turci M, Lodewick J, Di Gennaro G, Rinaldi AS, Marin O, Diani E, Sampaio C, Bex F, Bertazzoni U, Romanelli MG.

Retrovirology. 2012 Dec 7;9:102. doi: 10.1186/1742-4690-9-102.


Ubiquitin-specific peptidase 20 targets TRAF6 and human T cell leukemia virus type 1 tax to negatively regulate NF-kappaB signaling.

Yasunaga J, Lin FC, Lu X, Jeang KT.

J Virol. 2011 Jul;85(13):6212-9. doi: 10.1128/JVI.00079-11. Epub 2011 Apr 27.


Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.

Geleziunas R, Ferrell S, Lin X, Mu Y, Cunningham ET Jr, Grant M, Connelly MA, Hambor JE, Marcu KB, Greene WC.

Mol Cell Biol. 1998 Sep;18(9):5157-65.


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