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Items: 1 to 20 of 65

1.

TP508 accelerates fracture repair by promoting cell growth over cell death.

Li X, Wang H, Touma E, Qi Y, Rousseau E, Quigg RJ, Ryaby JT.

Biochem Biophys Res Commun. 2007 Dec 7;364(1):187-93. Epub 2007 Aug 22.

PMID:
17942078
2.

Thrombin peptide (TP508) promotes fracture repair by up-regulating inflammatory mediators, early growth factors, and increasing angiogenesis.

Wang H, Li X, Tomin E, Doty SB, Lane JM, Carney DH, Ryaby JT.

J Orthop Res. 2005 May;23(3):671-9. Epub 2004 Dec 15.

3.

Thrombin peptide TP508 stimulates cellular events leading to angiogenesis, revascularization, and repair of dermal and musculoskeletal tissues.

Ryaby JT, Sheller MR, Levine BP, Bramlet DG, Ladd AL, Carney DH.

J Bone Joint Surg Am. 2006 Nov;88 Suppl 3:132-9. Review.

PMID:
17079379
5.

Thrombin peptide (TP508) promotes adipose tissue-derived stem cell proliferation via PI3 kinase/Akt pathway.

Freyberg S, Song YH, Muehlberg F, Alt E.

J Vasc Res. 2009;46(2):98-102. doi: 10.1159/000142727. Epub 2008 Jul 7.

6.

Acceleration of full-thickness wound healing in normal rats by the synthetic thrombin peptide, TP508.

Stiernberg J, Norfleet AM, Redin WR, Warner WS, Fritz RR, Carney DH.

Wound Repair Regen. 2000 May-Jun;8(3):204-15.

PMID:
10886811
7.

Bone formation is enhanced by thrombin-related peptide TP508 during distraction osteogenesis.

Li G, Ryaby JT, Carney DH, Wang H.

J Orthop Res. 2005 Jan;23(1):196-202.

8.

Thrombin related peptide TP508 promoted fracture repair in a mouse high energy fracture model.

Hanratty BM, Ryaby JT, Pan XH, Li G.

J Orthop Surg Res. 2009 Jan 29;4:1. doi: 10.1186/1749-799X-4-1.

10.

Effect of thrombin peptide 508 (TP508) on bone healing during distraction osteogenesis in rabbit tibia.

Amir LR, Li G, Schoenmaker T, Everts V, Bronckers AL.

Cell Tissue Res. 2007 Oct;330(1):35-44. Epub 2007 Jul 17.

11.

Genetic network and pathway analysis of differentially expressed proteins during critical cellular events in fracture repair.

Li X, Wang H, Touma E, Rousseau E, Quigg RJ, Ryaby JT.

J Cell Biochem. 2007 Feb 1;100(2):527-43.

PMID:
16960878
12.

Thrombin peptide TP508 accelerates closure of dermal excisions in animal tissue with surgically induced ischemia.

Norfleet AM, Huang Y, Sower LE, Redin WR, Fritz RR, Carney DH.

Wound Repair Regen. 2000 Nov-Dec;8(6):517-29.

PMID:
11208179
13.

A single percutaneous injection of recombinant human bone morphogenetic protein-2 accelerates fracture repair.

Einhorn TA, Majeska RJ, Mohaideen A, Kagel EM, Bouxsein ML, Turek TJ, Wozney JM.

J Bone Joint Surg Am. 2003 Aug;85-A(8):1425-35.

PMID:
12925621
14.

Thrombin peptide, TP508, induces differential gene expression in fibroblasts through a nonproteolytic activation pathway.

Sower LE, Payne DA, Meyers R, Carney DH.

Exp Cell Res. 1999 Mar 15;247(2):422-31.

PMID:
10066370
15.

Repair of rabbit segmental defects with the thrombin peptide, TP508.

Sheller MR, Crowther RS, Kinney JH, Yang J, Di Jorio S, Breunig T, Carney DH, Ryaby JT.

J Orthop Res. 2004 Sep;22(5):1094-9.

16.
17.

On the mode of action of thrombin-induced angiogenesis: thrombin peptide, TP508, mediates effects in endothelial cells via alphavbeta3 integrin.

Tsopanoglou NE, Papaconstantinou ME, Flordellis CS, Maragoudakis ME.

Thromb Haemost. 2004 Oct;92(4):846-57.

PMID:
15467917
18.

rhBMP-2, rhVEGF(165), rhPTN and thrombin-related peptide, TP508 induce chemotaxis of human osteoblasts and microvascular endothelial cells.

Li G, Cui Y, McIlmurray L, Allen WE, Wang H.

J Orthop Res. 2005 May;23(3):680-5. Epub 2005 Apr 7.

19.

RGD-dependent binding of TP508 to integrin alphavbeta3 mediates cell adhesion and induction of nitric oxide.

Derkach DN, Wadekar SA, Perkins KB, Rousseau E, Dreiza CM, Cheung-Flynn J, Ramos HC, Ugarova TP, Sheller MR.

Thromb Haemost. 2010 Jul;104(1):172-82. doi: 10.1160/TH09-07-0447. Epub 2010 May 27.

20.

Human parathyroid hormone (1-34) accelerates natural fracture healing process in the femoral osteotomy model of cynomolgus monkeys.

Manabe T, Mori S, Mashiba T, Kaji Y, Iwata K, Komatsubara S, Seki A, Sun YX, Yamamoto T.

Bone. 2007 Jun;40(6):1475-82. Epub 2007 Feb 2.

PMID:
17369013

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