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Familial Alzheimer's disease mutations alter the stability of the amyloid beta-protein monomer folding nucleus.

Grant MA, Lazo ND, Lomakin A, Condron MM, Arai H, Yamin G, Rigby AC, Teplow DB.

Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16522-7. Epub 2007 Oct 10.


On the nucleation of amyloid beta-protein monomer folding.

Lazo ND, Grant MA, Condron MC, Rigby AC, Teplow DB.

Protein Sci. 2005 Jun;14(6):1581-96.


Folding events in the 21-30 region of amyloid beta-protein (Abeta) studied in silico.

Borreguero JM, Urbanc B, Lazo ND, Buldyrev SV, Teplow DB, Stanley HE.

Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6015-20. Epub 2005 Apr 18.


Structural dynamics of the amyloid β-protein monomer folding nucleus.

Roychaudhuri R, Yang M, Condron MM, Teplow DB.

Biochemistry. 2012 May 15;51(19):3957-9. doi: 10.1021/bi300350p. Epub 2012 May 7.


Dual effects of familial Alzheimer's disease mutations (D7H, D7N, and H6R) on amyloid β peptide: correlation dynamics and zinc binding.

Xu L, Chen Y, Wang X.

Proteins. 2014 Dec;82(12):3286-97. doi: 10.1002/prot.24669. Epub 2014 Oct 21.


In silico and in vitro studies to elucidate the role of Cu2+ and galanthamine as the limiting step in the amyloid beta (1-42) fibrillation process.

Hernández-Rodríguez M, Correa-Basurto J, Benitez-Cardoza CG, Resendiz-Albor AA, Rosales-Hernández MC.

Protein Sci. 2013 Oct;22(10):1320-35. doi: 10.1002/pro.2319. Epub 2013 Aug 19.


Solvent and mutation effects on the nucleation of amyloid beta-protein folding.

Cruz L, Urbanc B, Borreguero JM, Lazo ND, Teplow DB, Stanley HE.

Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18258-63. Epub 2005 Dec 9.


Amyloid β-Protein Assembly: Differential Effects of the Protective A2T Mutation and Recessive A2V Familial Alzheimer's Disease Mutation.

Zheng X, Liu D, Roychaudhuri R, Teplow DB, Bowers MT.

ACS Chem Neurosci. 2015 Oct 21;6(10):1732-40. doi: 10.1021/acschemneuro.5b00171. Epub 2015 Aug 12.


Familial Alzheimer's disease mutations differentially alter amyloid β-protein oligomerization.

Gessel MM, Bernstein S, Kemper M, Teplow DB, Bowers MT.

ACS Chem Neurosci. 2012 Nov 21;3(11):909-18. doi: 10.1021/cn300050d. Epub 2012 Jun 26.


Effects of the English (H6R) and Tottori (D7N) familial Alzheimer disease mutations on amyloid beta-protein assembly and toxicity.

Ono K, Condron MM, Teplow DB.

J Biol Chem. 2010 Jul 23;285(30):23186-97. doi: 10.1074/jbc.M109.086496. Epub 2010 May 7.


Effects of familial Alzheimer's disease mutations on the folding nucleation of the amyloid beta-protein.

Krone MG, Baumketner A, Bernstein SL, Wyttenbach T, Lazo ND, Teplow DB, Bowers MT, Shea JE.

J Mol Biol. 2008 Aug 1;381(1):221-8. doi: 10.1016/j.jmb.2008.05.069. Epub 2008 Jun 4.


Role of the familial Dutch mutation E22Q in the folding and aggregation of the 15-28 fragment of the Alzheimer amyloid-beta protein.

Baumketner A, Krone MG, Shea JE.

Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6027-32. doi: 10.1073/pnas.0708193105. Epub 2008 Apr 11.


Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin.

Betts V, Leissring MA, Dolios G, Wang R, Selkoe DJ, Walsh DM.

Neurobiol Dis. 2008 Sep;31(3):442-50. doi: 10.1016/j.nbd.2008.06.001. Epub 2008 Jun 17.


Structural dynamics of the ΔE22 (Osaka) familial Alzheimer's disease-linked amyloid β-protein.

Inayathullah M, Teplow DB.

Amyloid. 2011 Sep;18(3):98-107. doi: 10.3109/13506129.2011.580399. Epub 2011 Jun 13.


Familial Alzheimer's disease Osaka mutant (ΔE22) β-barrels suggest an explanation for the different Aβ1-40/42 preferred conformational states observed by experiment.

Jang H, Arce FT, Ramachandran S, Kagan BL, Lal R, Nussinov R.

J Phys Chem B. 2013 Oct 3;117(39):11518-29. doi: 10.1021/jp405389n. Epub 2013 Sep 13.


Effects of familial mutations on the monomer structure of Aβ₄₂.

Lin YS, Pande VS.

Biophys J. 2012 Dec 19;103(12):L47-9. doi: 10.1016/j.bpj.2012.11.009. Epub 2012 Dec 18.


Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis.

Kirkitadze MD, Condron MM, Teplow DB.

J Mol Biol. 2001 Oct 5;312(5):1103-19.

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