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Items: 1 to 20 of 78

1.

Induction of immunosuppressive molecules and regulatory T cells counteracts the antitumor effect of interleukin-12-based gene therapy in a transgenic mouse model of liver cancer.

Zabala M, Lasarte JJ, Perret C, Sola J, Berraondo P, Alfaro M, Larrea E, Prieto J, Kramer MG.

J Hepatol. 2007 Dec;47(6):807-15. Epub 2007 Oct 1.

PMID:
17935823
2.
3.

Electroporation-mediated interleukin-12 gene therapy for hepatocellular carcinoma in the mice model.

Yamashita YI, Shimada M, Hasegawa H, Minagawa R, Rikimaru T, Hamatsu T, Tanaka S, Shirabe K, Miyazaki JI, Sugimachi K.

Cancer Res. 2001 Feb 1;61(3):1005-12.

4.

Combination nonviral interleukin-2 gene immunotherapy for head and neck cancer: from bench top to bedside.

O'Malley BW Jr, Li D, McQuone SJ, Ralston R.

Laryngoscope. 2005 Mar;115(3):391-404.

PMID:
15744147
5.

Interferon-gamma produced by interleukin-12-activated tumor infiltrating CD8+T cells directly induces apoptosis of mouse hepatocellular carcinoma.

Komita H, Homma S, Saotome H, Zeniya M, Ohno T, Toda G.

J Hepatol. 2006 Nov;45(5):662-72. Epub 2006 Jul 7.

PMID:
16935390
6.

Intratumoral delivery of IL-18 naked DNA induces T-cell activation and Th1 response in a mouse hepatic cancer model.

Chang CY, Lee J, Kim EY, Park HJ, Kwon CH, Joh JW, Kim SJ.

BMC Cancer. 2007 May 23;7:87.

7.

Prolonged, NK cell-mediated antitumor effects of suicide gene therapy combined with monocyte chemoattractant protein-1 against hepatocellular carcinoma.

Tsuchiyama T, Nakamoto Y, Sakai Y, Marukawa Y, Kitahara M, Mukaida N, Kaneko S.

J Immunol. 2007 Jan 1;178(1):574-83.

8.

Gene therapy with CX3CL1/Fractalkine induces antitumor immunity to regress effectively mouse hepatocellular carcinoma.

Tang L, Hu HD, Hu P, Lan YH, Peng ML, Chen M, Ren H.

Gene Ther. 2007 Aug;14(16):1226-34. Epub 2007 Jun 28.

PMID:
17597794
9.

Optimization of the Tet-on system to regulate interleukin 12 expression in the liver for the treatment of hepatic tumors.

Zabala M, Wang L, Hernandez-Alcoceba R, Hillen W, Qian C, Prieto J, Kramer MG.

Cancer Res. 2004 Apr 15;64(8):2799-804.

10.

Expression of interleukins-23 and 27 leads to successful gene therapy of hepatocellular carcinoma.

Hu P, Hu HD, Chen M, Peng ML, Tang L, Tang KF, Matsui M, Belladonna ML, Yoshimoto T, Zhang DZ, Xiang R, Ren H.

Mol Immunol. 2009 May;46(8-9):1654-62. doi: 10.1016/j.molimm.2009.02.025. Epub 2009 Mar 18.

PMID:
19299021
11.

IL-12 gene therapy is an effective therapeutic strategy for hepatocellular carcinoma in immunosuppressed mice.

Harada N, Shimada M, Okano S, Suehiro T, Soejima Y, Tomita Y, Maehara Y.

J Immunol. 2004 Dec 1;173(11):6635-44.

12.

Treatment of murine hepatocellular carcinoma using genetically modified cells to express interleukin-12.

Peron JM, Couderc B, Rochaix P, Douin-Echinard V, Asnacios A, Souque A, Voigt JJ, Buscail L, Vinel JP, Favre G.

J Gastroenterol Hepatol. 2004 Apr;19(4):388-96.

PMID:
15012775
13.

Antitumor and antiangiogenic effects of interleukin 12 gene therapy in murine head and neck carcinoma model.

Imagawa Y, Satake K, Kato Y, Tahara H, Tsukuda M.

Auris Nasus Larynx. 2004 Sep;31(3):239-45.

PMID:
15364358
14.

[Effects of interleukin-12 transfection on proliferation of ovarian cancer SKOV3 cells in vitro and in vivo].

Wang J, Zhang CQ, Liu J, Sui LH.

Ai Zheng. 2007 Dec;26(12):1292-8. Chinese.

PMID:
18076789
15.

AdCD40L gene therapy counteracts T regulatory cells and cures aggressive tumors in an orthotopic bladder cancer model.

Loskog AS, Fransson ME, Totterman TT.

Clin Cancer Res. 2005 Dec 15;11(24 Pt 1):8816-21.

16.

IL-12 cDNA direct injection: antimetastatic effect from a single injection in a murine hepatic metastases model.

Weber SM, Qi C, Neal Z, Sondel P, Mahvi DM.

J Surg Res. 2004 Dec;122(2):210-7.

PMID:
15555620
17.

Interleukin-12 inhibits liver-specific drug-inducible systems in vivo.

Reboredo M, Zabala M, Mauleon I, De Las Rivas J, Kreppel F, Kochanek S, Prieto J, Hernandez-Alcoceba R, Kramer MG.

Gene Ther. 2008 Feb;15(4):277-88. Epub 2007 Nov 22.

PMID:
18033307
18.

Large nontransplanted hepatocellular carcinoma in woodchucks: treatment with adenovirus-mediated delivery of interleukin 12/B7.1 genes.

Pützer BM, Stiewe T, Rödicker F, Schildgen O, Rühm S, Dirsch O, Fiedler M, Damen U, Tennant B, Scherer C, Graham FL, Roggendorf M.

J Natl Cancer Inst. 2001 Mar 21;93(6):472-9.

PMID:
11259473
19.

Antitumor mechanism of intratumoral injection with IL-12-expressing adenoviral vector against IL-12-unresponsive tumor.

Kanagawa N, Gao JQ, Motomura Y, Yanagawa T, Mukai Y, Yoshioka Y, Okada N, Nakagawa S.

Biochem Biophys Res Commun. 2008 Aug 8;372(4):821-5. doi: 10.1016/j.bbrc.2008.05.129. Epub 2008 Jun 2.

PMID:
18519033
20.

Short-term intratumoral interleukin-12 expressed from an alphaviral vector is sufficient to induce an efficient antitumoral response against spontaneous hepatocellular carcinomas.

Rodriguez-Madoz JR, Zabala M, Alfaro M, Prieto J, Kramer MG, Smerdou C.

Hum Gene Ther. 2014 Feb;25(2):132-43. doi: 10.1089/hum.2013.080. Epub 2014 Jan 7.

PMID:
24219025

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