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Responses of biomarkers of folate and riboflavin status to folate and riboflavin supplementation in healthy and colorectal polyp patients (the FAB2 Study).

Powers HJ, Hill MH, Welfare M, Spiers A, Bal W, Russell J, Duckworth Y, Gibney E, Williams EA, Mathers JC.

Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):2128-35.


Effect of riboflavin status on the homocysteine-lowering effect of folate in relation to the MTHFR (C677T) genotype.

Moat SJ, Ashfield-Watt PA, Powers HJ, Newcombe RG, McDowell IF.

Clin Chem. 2003 Feb;49(2):295-302.


Systemic folate status, rectal mucosal folate concentration and dietary intake in patients at differential risk of bowel cancer (The FAB2 Study).

Williams EA, Welfare M, Spiers A, Hill MH, Bal W, Gibney ER, Duckworth Y, Powers HJ, Mathers JC.

Eur J Nutr. 2013 Oct;52(7):1801-10. doi: 10.1007/s00394-012-0483-5. Epub 2012 Dec 28.


Response of serum and red blood cell folate concentrations to folic acid supplementation depends on methylenetetrahydrofolate reductase C677T genotype: results from a crossover trial.

Anderson CA, Beresford SA, McLerran D, Lampe JW, Deeb S, Feng Z, Motulsky AG.

Mol Nutr Food Res. 2013 Apr;57(4):637-44. doi: 10.1002/mnfr.201200108. Epub 2013 Mar 4.


Optimization of dietary folate or low-dose folic acid supplements lower homocysteine but do not enhance endothelial function in healthy adults, irrespective of the methylenetetrahydrofolate reductase (C677T) genotype.

Pullin CH, Ashfield-Watt PA, Burr ML, Clark ZE, Lewis MJ, Moat SJ, Newcombe RG, Powers HJ, Whiting JM, McDowell IF.

J Am Coll Cardiol. 2001 Dec;38(7):1799-805.


The association between MTHFR 677C>T genotype and folate status and genomic and gene-specific DNA methylation in the colon of individuals without colorectal neoplasia.

Hanks J, Ayed I, Kukreja N, Rogers C, Harris J, Gheorghiu A, Liu CL, Emery P, Pufulete M.

Am J Clin Nutr. 2013 Dec;98(6):1564-74. doi: 10.3945/ajcn.113.061432. Epub 2013 Oct 9.


Low dietary riboflavin but not folate predicts increased fracture risk in postmenopausal women homozygous for the MTHFR 677 T allele.

Yazdanpanah N, Uitterlinden AG, Zillikens MC, Jhamai M, Rivadeneira F, Hofman A, de Jonge R, Lindemans J, Pols HA, van Meurs JB.

J Bone Miner Res. 2008 Jan;23(1):86-94.


The impact of MTHFR 677 C/T genotypes on folate status markers: a meta-analysis of folic acid intervention studies.

Colson NJ, Naug HL, Nikbakht E, Zhang P, McCormack J.

Eur J Nutr. 2017 Feb;56(1):247-260. doi: 10.1007/s00394-015-1076-x. Epub 2015 Oct 23.


Effect of folic Acid supplementation on the folate status of buccal mucosa and lymphocytes.

Basten GP, Hill MH, Duthie SJ, Powers HJ.

Cancer Epidemiol Biomarkers Prev. 2004 Jul;13(7):1244-9.


Folic Acid Supplementation in Postpolypectomy Patients in a Randomized Controlled Trial Increases Tissue Folate Concentrations and Reduces Aberrant DNA Biomarkers in Colonic Tissues Adjacent to the Former Polyp Site.

O'Reilly SL, McGlynn AP, McNulty H, Reynolds J, Wasson GR, Molloy AM, Strain JJ, Weir DG, Ward M, McKerr G, Scott JM, Downes CS.

J Nutr. 2016 May;146(5):933-9. doi: 10.3945/jn.115.222547. Epub 2016 Apr 13.


Homocysteine and folate status in methotrexate-treated patients with rheumatoid arthritis.

van Ede AE, Laan RF, Blom HJ, Boers GH, Haagsma CJ, Thomas CM, De Boo TM, van de Putte LB.

Rheumatology (Oxford). 2002 Jun;41(6):658-65.


Supplementation with a multivitamin containing 800 microg of folic acid shortens the time to reach the preventive red blood cell folate concentration in healthy women.

Brämswig S, Prinz-Langenohl R, Lamers Y, Tobolski O, Wintergerst E, Berthold HK, Pietrzik K.

Int J Vitam Nutr Res. 2009 Mar;79(2):61-70. doi: 10.1024/0300-9831.79.2.61.


Effects of short-term folic acid and/or riboflavin supplementation on serum folate and plasma total homocysteine concentrations in young Japanese male subjects.

Araki R, Maruyama C, Igarashi S, Yoshida M, Maruyama T, Satoh T, Yoshida M, Umegaki K.

Eur J Clin Nutr. 2006 May;60(5):573-9.


Methylenetetrahydrofolate reductase 677C-->T genotype modulates homocysteine responses to a folate-rich diet or a low-dose folic acid supplement: a randomized controlled trial.

Ashfield-Watt PA, Pullin CH, Whiting JM, Clark ZE, Moat SJ, Newcombe RG, Burr ML, Lewis MJ, Powers HJ, McDowell IF.

Am J Clin Nutr. 2002 Jul;76(1):180-6.


Folate status and risk of colorectal polyps in African Americans.

Ashktorab H, Begum R, Akhgar A, Smoot DT, Elbedawi M, Daremipouran M, Zhao A, Momen B, Giardiello FM.

Dig Dis Sci. 2007 Jun;52(6):1462-70. Epub 2007 Mar 20.


MTHFR Gene polymorphisms, B-vitamins and hyperhomocystinemia in young and middle-aged acute myocardial infarction patients.

Angeline T, Jeyaraj N, Tsongalis GJ.

Exp Mol Pathol. 2007 Jun;82(3):227-33. Epub 2007 Mar 1.


Low-dose vitamin B-6 effectively lowers fasting plasma homocysteine in healthy elderly persons who are folate and riboflavin replete.

McKinley MC, McNulty H, McPartlin J, Strain JJ, Pentieva K, Ward M, Weir DG, Scott JM.

Am J Clin Nutr. 2001 Apr;73(4):759-64.

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