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Patients with curative resection of cT3-4 rectal cancer after preoperative radiotherapy or radiochemotherapy: does anybody benefit from adjuvant fluorouracil-based chemotherapy? A trial of the European Organisation for Research and Treatment of Cancer Radiation Oncology Group.

Collette L, Bosset JF, den Dulk M, Nguyen F, Mineur L, Maingon P, Radosevic-Jelic L, Piérart M, Calais G; European Organisation for Research and Treatment of Cancer Radiation Oncology Group..

J Clin Oncol. 2007 Oct 1;25(28):4379-86.


Lymph node status and TS gene expression are prognostic markers in stage II/III rectal cancer after neoadjuvant fluorouracil-based chemoradiotherapy.

Liersch T, Langer C, Ghadimi BM, Kulle B, Aust DE, Baretton GB, Schwabe W, Häusler P, Becker H, Jakob C.

J Clin Oncol. 2006 Sep 1;24(25):4062-8.


Prognostic implications of response to preoperative infusional chemoradiation in locally advanced rectal cancer.

Janjan NA, Abbruzzese J, Pazdur R, Khoo VS, Cleary K, Dubrow R, Ajani J, Rich TA, Goswitz MS, Evetts PA, Allen PK, Lynch PM, Skibber JM.

Radiother Oncol. 1999 May;51(2):153-60.


A quality-adjusted time without symptoms or toxicity (Q-TWiST) analysis of adjuvant radiation therapy and chemotherapy for resectable rectal cancer.

Gelber RD, Goldhirsch A, Cole BF, Wieand HS, Schroeder G, Krook JE.

J Natl Cancer Inst. 1996 Aug 7;88(15):1039-45.


Prognostic value of pathologic complete response after neoadjuvant therapy in locally advanced rectal cancer: long-term analysis of 566 ypCR patients.

Capirci C, Valentini V, Cionini L, De Paoli A, Rodel C, Glynne-Jones R, Coco C, Romano M, Mantello G, Palazzi S, Mattia FO, Friso ML, Genovesi D, Vidali C, Gambacorta MA, Buffoli A, Lupattelli M, Favretto MS, La Torre G.

Int J Radiat Oncol Biol Phys. 2008 Sep 1;72(1):99-107. doi: 10.1016/j.ijrobp.2007.12.019.


Preoperative radio-chemotherapy (RT-CT) in rectal cancer. Prospective study with postoperative RT-CT control group.

Cambray i Amenós M, Navarro García M, Martí Ragué J, Pareja Fernández L, Pera Fábregas J.

Clin Transl Oncol. 2007 Mar;9(3):183-91.


Phase III trial of fluorouracil-based chemotherapy regimens plus radiotherapy in postoperative adjuvant rectal cancer: GI INT 0144.

Smalley SR, Benedetti JK, Williamson SK, Robertson JM, Estes NC, Maher T, Fisher B, Rich TA, Martenson JA, Kugler JW, Benson AB 3rd, Haller DG, Mayer RJ, Atkins JN, Cripps C, Pedersen J, Periman PO, Tanaka MS Jr, Leichman CG, Macdonald JS.

J Clin Oncol. 2006 Aug 1;24(22):3542-7.


Adjuvant chemotherapy with folinic acid and 5-fluorouracil in patients with locally advanced rectal cancer previously treated by preoperative radiochemotherapy and curative tumor resection.

Hildebrandt B, Rau B, Löffel J, Wust P, Nicolaou A, Gellermann J, Le Coutre P, Neuhaus P, Felix R, Wernecke KD, Dörken B, Riess H.

Int J Colorectal Dis. 2006 Sep;21(6):582-9.


Preoperative short-course radiotherapy versus combined radiochemotherapy in locally advanced rectal cancer: a multi-centre prospectively randomised study of the Berlin Cancer Society.

Siegel R, Burock S, Wernecke KD, Kretzschmar A, Dietel M, Loy V, Koswig S, Budach V, Schlag PM.

BMC Cancer. 2009 Feb 6;9:50. doi: 10.1186/1471-2407-9-50.


Effect of preoperative radiochemotherapy on lymph node retrieval after resection of rectal cancer.

Wichmann MW, Müller C, Meyer G, Strauss T, Hornung HM, Lau-Werner U, Angele MK, Schildberg FW.

Arch Surg. 2002 Feb;137(2):206-10.


Randomized phase III study comparing preoperative radiotherapy with chemoradiotherapy in nonresectable rectal cancer.

Braendengen M, Tveit KM, Berglund A, Birkemeyer E, Frykholm G, Påhlman L, Wiig JN, Byström P, Bujko K, Glimelius B.

J Clin Oncol. 2008 Aug 1;26(22):3687-94. doi: 10.1200/JCO.2007.15.3858.


Retrospective long-term results and prognostic factors of postoperative treatment for UICC stages II and III rectal cancer.

Genovesi D, Cèfaro GA, Vinciguerra A, Augurio A, D'Alessandro M, Borzillo V, Marchese R, Di Nicola M.

Tumori. 2009 Nov-Dec;95(6):675-82.


Randomized clinical trial of adjuvant radiotherapy and 5-fluorouracil infusion in colorectal cancer (AXIS).

James RD, Donaldson D, Gray R, Northover JM, Stenning SP, Taylor I; AXIS collaborators..

Br J Surg. 2003 Oct;90(10):1200-12.


Preoperative chemoradiotherapy versus preoperative radiotherapy in rectal cancer patients: assessment of acute toxicity and treatment compliance. Report of the 22921 randomised trial conducted by the EORTC Radiotherapy Group.

Bosset JF, Calais G, Daban A, Berger C, Radosevic-Jelic L, Maingon P, Bardet E, Pierart M, Briffaux A; EORTC Radiotherapy Group..

Eur J Cancer. 2004 Jan;40(2):219-24.


Enhanced tumorocidal effect of chemotherapy with preoperative radiotherapy for rectal cancer: preliminary results--EORTC 22921.

Bosset JF, Calais G, Mineur L, Maingon P, Radosevic-Jelic L, Daban A, Bardet E, Beny A, Briffaux A, Collette L.

J Clin Oncol. 2005 Aug 20;23(24):5620-7.


Final results of a randomised phase III study on adjuvant chemotherapy with 5 FU and levamisol in colon and rectum cancer stage II and III by the Norwegian Gastrointestinal Cancer Group.

Dahl O, Fluge Ø, Carlsen E, Wiig JN, Myrvold HE, Vonen B, Podhorny N, Bjerkeset O, Eide TJ, Halvorsen TB, Tveit KM; Norwegian Gastrointestinal Cancer Group..

Acta Oncol. 2009;48(3):368-76. doi: 10.1080/02841860902755244.


Postoperative adjuvant chemotherapy or radiation therapy for rectal cancer: results from NSABP protocol R-01.

Fisher B, Wolmark N, Rockette H, Redmond C, Deutsch M, Wickerham DL, Fisher ER, Caplan R, Jones J, Lerner H, et al.

J Natl Cancer Inst. 1988 Mar 2;80(1):21-9.


Is adjuvant therapy with streptozotocin and 5-fluorouracil useful after resection of liver metastases from digestive endocrine tumors?

Maire F, Hammel P, Kianmanesh R, Hentic O, Couvelard A, Rebours V, Zappa M, Raymond E, Sauvanet A, Louvet C, Lévy P, Belghiti J, Ruszniewski P.

Surgery. 2009 Jan;145(1):69-75. doi: 10.1016/j.surg.2008.08.007.


Adjuvant therapy in pancreatic cancer: a critical appraisal.

Oettle H, Neuhaus P.

Drugs. 2007;67(16):2293-310. Review.

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