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Hypergastrinemia increases gastric epithelial susceptibility to apoptosis.

Przemeck SM, Varro A, Berry D, Steele I, Wang TC, Dockray GJ, Pritchard DM.

Regul Pept. 2008 Feb 7;146(1-3):147-56. Epub 2007 Sep 7.


Gastrin increases murine intestinal crypt regeneration following injury.

Ottewell PD, Duckworth CA, Varro A, Dimaline R, Wang TC, Watson AJ, Dockray GJ, Pritchard DM.

Gastroenterology. 2006 Apr;130(4):1169-80.


Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemia.

Fox JG, Wang TC, Rogers AB, Poutahidis T, Ge Z, Taylor N, Dangler CA, Israel DA, Krishna U, Gaus K, Peek RM Jr.

Gastroenterology. 2003 Jun;124(7):1879-90.


Importance of gastrin in the pathogenesis and treatment of gastric tumors.

Burkitt MD, Varro A, Pritchard DM.

World J Gastroenterol. 2009 Jan 7;15(1):1-16. Review.


Gastrin-induced apoptosis contributes to carcinogenesis in the stomach.

Cui G, Takaishi S, Ai W, Betz KS, Florholmen J, Koh TJ, Houghton J, Pritchard DM, Wang TC.

Lab Invest. 2006 Oct;86(10):1037-51. Epub 2006 Aug 7.


Combination of sulindac and antimicrobial eradication of Helicobacter pylori prevents progression of gastric cancer in hypergastrinemic INS-GAS mice.

Lee CW, Rickman B, Rogers AB, Muthupalani S, Takaishi S, Yang P, Wang TC, Fox JG.

Cancer Res. 2009 Oct 15;69(20):8166-74. doi: 10.1158/0008-5472.CAN-08-3856. Epub 2009 Oct 13.


Deletion of Men1 and somatostatin induces hypergastrinemia and gastric carcinoids.

Sundaresan S, Kang AJ, Hayes MM, Choi EK, Merchant JL.

Gut. 2017 Jun;66(6):1012-1021. doi: 10.1136/gutjnl-2015-310928. Epub 2016 Feb 9. Erratum in: Gut. 2017 Nov;66(11):2012.


Helicobacter pylori eradication prevents progression of gastric cancer in hypergastrinemic INS-GAS mice.

Lee CW, Rickman B, Rogers AB, Ge Z, Wang TC, Fox JG.

Cancer Res. 2008 May 1;68(9):3540-8. doi: 10.1158/0008-5472.CAN-07-6786. Epub 2008 Apr 25.


Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer.

Takaishi S, Cui G, Frederick DM, Carlson JE, Houghton J, Varro A, Dockray GJ, Ge Z, Whary MT, Rogers AB, Fox JG, Wang TC.

Gastroenterology. 2005 Jun;128(7):1965-83.


Effect of probiotics and triple eradication therapy on the cyclooxygenase (COX)-2 expression, apoptosis, and functional gastric mucosal impairment in Helicobacter pylori-infected Mongolian gerbils.

Brzozowski T, Konturek PC, Mierzwa M, Drozdowicz D, Bielanski W, Kwiecien S, Konturek SJ, Stachura J, Pawlik WW, Hahn EG.

Helicobacter. 2006 Feb;11(1):10-20.


Gastrin is an essential cofactor for helicobacter-associated gastric corpus carcinogenesis in C57BL/6 mice.

Takaishi S, Tu S, Dubeykovskaya ZA, Whary MT, Muthupalani S, Rickman BH, Rogers AB, Lertkowit N, Varro A, Fox JG, Wang TC.

Am J Pathol. 2009 Jul;175(1):365-75. doi: 10.2353/ajpath.2009.081165.


Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia.

Lofgren JL, Whary MT, Ge Z, Muthupalani S, Taylor NS, Mobley M, Potter A, Varro A, Eibach D, Suerbaum S, Wang TC, Fox JG.

Gastroenterology. 2011 Jan;140(1):210-20. doi: 10.1053/j.gastro.2010.09.048. Epub 2010 Oct 13.


Hypergastrinemia is associated with adenocarcinomas in the gastric corpus and shorter patient survival.

Fossmark R, Sagatun L, Nordrum IS, Sandvik AK, Waldum HL.

APMIS. 2015 Jun;123(6):509-14. doi: 10.1111/apm.12380. Epub 2015 May 5.


Helicobacter pylori can induce heparin-binding epidermal growth factor expression via gastrin and its receptor.

Dickson JH, Grabowska A, El-Zaatari M, Atherton J, Watson SA.

Cancer Res. 2006 Aug 1;66(15):7524-31.


Triple eradication therapy counteracts functional impairment associated with Helicobacter pylori infection in Mongolian gerbils.

Brzozowski T, Konturek PC, Kwiecien S, Konturek SJ, Pajdo R, Drozdowicz D, Ptak A, Pawlik M, Stachura J, Pawlik WW, Hahn EG.

J Physiol Pharmacol. 2003 Mar;54(1):33-51.


Hypergastrinemia in response to gastric inflammation suppresses somatostatin.

Zavros Y, Rieder G, Ferguson A, Samuelson LC, Merchant JL.

Am J Physiol Gastrointest Liver Physiol. 2002 Jan;282(1):G175-83.


Gastric antisecretory drugs induce leukocyte-endothelial cell interactions through gastrin release and activation of CCK-2 receptors.

Alvarez A, Ibiza MS, Andrade MM, Blas-García A, Calatayud S.

J Pharmacol Exp Ther. 2007 Oct;323(1):406-13. Epub 2007 Jul 24.


17 β-estradiol suppresses Helicobacter pylori-induced gastric pathology in male hypergastrinemic INS-GAS mice.

Ohtani M, Ge Z, García A, Rogers AB, Muthupalani S, Taylor NS, Xu S, Watanabe K, Feng Y, Marini RP, Whary MT, Wang TC, Fox JG.

Carcinogenesis. 2011 Aug;32(8):1244-50. doi: 10.1093/carcin/bgr072. Epub 2011 May 11.


Effects of melatonin and tryptophan on healing of gastric and duodenal ulcers with Helicobacter pylori infection in humans.

Celinski K, Konturek PC, Konturek SJ, Slomka M, Cichoz-Lach H, Brzozowski T, Bielanski W.

J Physiol Pharmacol. 2011 Oct;62(5):521-6.


Hypergastrinemia after Helicobacter pylori infection is associated with bacterial load and related inflammation of the oxyntic corpus mucosa.

Chuang CH, Sheu BS, Yang HB, Kao AW, Cheng HC, Yao WJ.

J Gastroenterol Hepatol. 2004 Sep;19(9):988-93.


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