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Items: 1 to 20 of 85

1.

Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival.

Yang H, Yang T, Baur JA, Perez E, Matsui T, Carmona JJ, Lamming DW, Souza-Pinto NC, Bohr VA, Rosenzweig A, de Cabo R, Sauve AA, Sinclair DA.

Cell. 2007 Sep 21;130(6):1095-107.

2.
3.

Mitochondrial sirtuins.

Huang JY, Hirschey MD, Shimazu T, Ho L, Verdin E.

Biochim Biophys Acta. 2010 Aug;1804(8):1645-51. doi: 10.1016/j.bbapap.2009.12.021. Epub 2010 Jan 7. Review.

PMID:
20060508
4.

Protein kinase C epsilon regulates mitochondrial pools of Nampt and NAD following resveratrol and ischemic preconditioning in the rat cortex.

Morris-Blanco KC, Cohan CH, Neumann JT, Sick TJ, Perez-Pinzon MA.

J Cereb Blood Flow Metab. 2014 Jun;34(6):1024-32. doi: 10.1038/jcbfm.2014.51. Epub 2014 Mar 26.

5.

Mitochondrial metabolism, sirtuins, and aging.

Sack MN, Finkel T.

Cold Spring Harb Perspect Biol. 2012 Dec 1;4(12). pii: a013102. doi: 10.1101/cshperspect.a013102. Review.

6.

NAD+-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10.

Yang Y, Cimen H, Han MJ, Shi T, Deng JH, Koc H, Palacios OM, Montier L, Bai Y, Tong Q, Koc EC.

J Biol Chem. 2010 Mar 5;285(10):7417-29. doi: 10.1074/jbc.M109.053421. Epub 2009 Dec 30.

7.

Enzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promoters.

Zhang T, Berrocal JG, Frizzell KM, Gamble MJ, DuMond ME, Krishnakumar R, Yang T, Sauve AA, Kraus WL.

J Biol Chem. 2009 Jul 24;284(30):20408-17. doi: 10.1074/jbc.M109.016469. Epub 2009 May 28.

8.

Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5.

Schlicker C, Gertz M, Papatheodorou P, Kachholz B, Becker CF, Steegborn C.

J Mol Biol. 2008 Oct 10;382(3):790-801. doi: 10.1016/j.jmb.2008.07.048. Epub 2008 Jul 25.

PMID:
18680753
9.

Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes.

Hsu CP, Oka S, Shao D, Hariharan N, Sadoshima J.

Circ Res. 2009 Aug 28;105(5):481-91. doi: 10.1161/CIRCRESAHA.109.203703. Epub 2009 Aug 6.

10.

FK866 compromises mitochondrial metabolism and adaptive stress responses in cultured cardiomyocytes.

Oyarzún AP, Westermeier F, Pennanen C, López-Crisosto C, Parra V, Sotomayor-Flores C, Sánchez G, Pedrozo Z, Troncoso R, Lavandero S.

Biochem Pharmacol. 2015 Nov 1;98(1):92-101. doi: 10.1016/j.bcp.2015.08.097. Epub 2015 Aug 20.

PMID:
26297909
11.

Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5.

Nakamura Y, Ogura M, Tanaka D, Inagaki N.

Biochem Biophys Res Commun. 2008 Feb 1;366(1):174-9. Epub 2007 Dec 3.

PMID:
18054327
12.

Nicotinamide phosphoribosyltransferase and SIRT3 expression are increased in well-differentiated thyroid carcinomas.

Shackelford R, Hirsh S, Henry K, Abdel-Mageed A, Kandil E, Coppola D.

Anticancer Res. 2013 Aug;33(8):3047-52.

PMID:
23898059
13.

Nicotinamide improves glucose metabolism and affects the hepatic NAD-sirtuin pathway in a rodent model of obesity and type 2 diabetes.

Yang SJ, Choi JM, Kim L, Park SE, Rhee EJ, Lee WY, Oh KW, Park SW, Park CY.

J Nutr Biochem. 2014 Jan;25(1):66-72. doi: 10.1016/j.jnutbio.2013.09.004. Epub 2013 Oct 10.

PMID:
24314867
14.

Neuronal Sirt3 protects against excitotoxic injury in mouse cortical neuron culture.

Kim SH, Lu HF, Alano CC.

PLoS One. 2011 Mar 1;6(3):e14731. doi: 10.1371/journal.pone.0014731.

15.

SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70.

Sundaresan NR, Samant SA, Pillai VB, Rajamohan SB, Gupta MP.

Mol Cell Biol. 2008 Oct;28(20):6384-401. doi: 10.1128/MCB.00426-08. Epub 2008 Aug 18.

16.

Nicotinamide phosphoribosyl transferase (Nampt) is required for de novo lipogenesis in tumor cells.

Bowlby SC, Thomas MJ, D'Agostino RB Jr, Kridel SJ.

PLoS One. 2012;7(6):e40195. doi: 10.1371/journal.pone.0040195. Epub 2012 Jun 29.

17.

Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt.

Fulco M, Cen Y, Zhao P, Hoffman EP, McBurney MW, Sauve AA, Sartorelli V.

Dev Cell. 2008 May;14(5):661-73. doi: 10.1016/j.devcel.2008.02.004.

18.

Up-regulation of nicotinamide phosphoribosyltransferase and increase of NAD+ levels by glucose restriction extend replicative lifespan of human fibroblast Hs68 cells.

Yang NC, Song TY, Chang YZ, Chen MY, Hu ML.

Biogerontology. 2015 Feb;16(1):31-42. doi: 10.1007/s10522-014-9528-x. Epub 2014 Aug 22.

PMID:
25146190
19.

Sirt3 attenuates hydrogen peroxide-induced oxidative stress through the preservation of mitochondrial function in HT22 cells.

Dai SH, Chen T, Wang YH, Zhu J, Luo P, Rao W, Yang YF, Fei Z, Jiang XF.

Int J Mol Med. 2014 Oct;34(4):1159-68. doi: 10.3892/ijmm.2014.1876. Epub 2014 Aug 4.

PMID:
25090966
20.

SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism.

Hirschey MD, Shimazu T, Huang JY, Schwer B, Verdin E.

Cold Spring Harb Symp Quant Biol. 2011;76:267-77. doi: 10.1101/sqb.2011.76.010850. Epub 2011 Nov 23. Review.

PMID:
22114326

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