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Differential costimulation through CD137 (4-1BB) restores proliferation of human virus-specific "effector memory" (CD28(-) CD45RA(HI)) CD8(+) T cells.

Waller EC, McKinney N, Hicks R, Carmichael AJ, Sissons JG, Wills MR.

Blood. 2007 Dec 15;110(13):4360-6. Epub 2007 Sep 18.


CD8+CD45RA+CD27-CD28-T-cell subset in PBL of cervical cancer patients representing CD8+T-cells being able to recognize cervical cancer associated antigens provided by HPV 16 E7.

Pilch H, Hoehn H, Schmidt M, Steiner E, Tanner B, Seufert R, Maeurer M.

Zentralbl Gynakol. 2002 Aug-Sep;124(8-9):406-12.


4-1BB is superior to CD28 costimulation for generating CD8+ cytotoxic lymphocytes for adoptive immunotherapy.

Zhang H, Snyder KM, Suhoski MM, Maus MV, Kapoor V, June CH, Mackall CL.

J Immunol. 2007 Oct 1;179(7):4910-8.


Role of 4-1BB (CD137) in the functional activation of cord blood CD28(-)CD8(+) T cells.

Kim YJ, Brutkiewicz RR, Broxmeyer HE.

Blood. 2002 Nov 1;100(9):3253-60.


Differentiation of human CD8(+) T cells from a memory to memory/effector phenotype.

Tomiyama H, Matsuda T, Takiguchi M.

J Immunol. 2002 Jun 1;168(11):5538-50.


Co-stimulation through 4-1BB/CD137 improves the expansion and function of CD8(+) melanoma tumor-infiltrating lymphocytes for adoptive T-cell therapy.

Chacon JA, Wu RC, Sukhumalchandra P, Molldrem JJ, Sarnaik A, Pilon-Thomas S, Weber J, Hwu P, Radvanyi L.

PLoS One. 2013;8(4):e60031. doi: 10.1371/journal.pone.0060031. Epub 2013 Apr 1.


Ex vivo culture of chimeric antigen receptor T cells generates functional CD8+ T cells with effector and central memory-like phenotype.

Neeson P, Shin A, Tainton KM, Guru P, Prince HM, Harrison SJ, Peinert S, Smyth MJ, Trapani JA, Kershaw MH, Darcy PK, Ritchie DS.

Gene Ther. 2010 Sep;17(9):1105-16. doi: 10.1038/gt.2010.59. Epub 2010 Apr 29.


A switch in costimulation from CD28 to 4-1BB during primary versus secondary CD8 T cell response to influenza in vivo.

Bertram EM, Dawicki W, Sedgmen B, Bramson JL, Lynch DH, Watts TH.

J Immunol. 2004 Jan 15;172(2):981-8.


Human CD28-CD8+ T cells contain greatly expanded functional virus-specific memory CTL clones.

Weekes MP, Carmichael AJ, Wills MR, Mynard K, Sissons JG.

J Immunol. 1999 Jun 15;162(12):7569-77.


Potent costimulation of human CD8 T cells by anti-4-1BB and anti-CD28 on synthetic artificial antigen presenting cells.

Rudolf D, Silberzahn T, Walter S, Maurer D, Engelhard J, Wernet D, Bühring HJ, Jung G, Kwon BS, Rammensee HG, Stevanović S.

Cancer Immunol Immunother. 2008 Feb;57(2):175-83. Epub 2007 Jul 27.


4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy.

Cannons JL, Lau P, Ghumman B, DeBenedette MA, Yagita H, Okumura K, Watts TH.

J Immunol. 2001 Aug 1;167(3):1313-24.


Costimulation through the CD137/4-1BB pathway protects human melanoma tumor-infiltrating lymphocytes from activation-induced cell death and enhances antitumor effector function.

Hernandez-Chacon JA, Li Y, Wu RC, Bernatchez C, Wang Y, Weber JS, Hwu P, Radvanyi LG.

J Immunother. 2011 Apr;34(3):236-50. doi: 10.1097/CJI.0b013e318209e7ec.


A subset of functional effector-memory CD8+ T lymphocytes in human immunodeficiency virus-infected patients.

Decrion AZ, Varin A, Drobacheff C, Estavoyer JM, Herbein G.

Immunology. 2007 Jul;121(3):405-15. Epub 2007 Mar 22.


4-1BBL costimulation retrieves CD28 expression in activated T cells.

Habib-Agahi M, Jaberipour M, Searle PF.

Cell Immunol. 2009;256(1-2):39-46. doi: 10.1016/j.cellimm.2009.01.003. Epub 2009 Feb 12.


T helper-independent activation of human CD8+ cells: the role of CD28 costimulation.

Van Gool SW, Zhang Y, Kasran A, de Boer M, Ceuppens JL.

Scand J Immunol. 1996 Jul;44(1):21-9.


Differential impact of CD27 and 4-1BB costimulation on effector and memory CD8 T cell generation following peptide immunization.

Willoughby JE, Kerr JP, Rogel A, Taraban VY, Buchan SL, Johnson PW, Al-Shamkhani A.

J Immunol. 2014 Jul 1;193(1):244-51. doi: 10.4049/jimmunol.1301217. Epub 2014 May 23.

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