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Items: 1 to 20 of 212

1.

Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase.

Li T, Wen H, Brayton C, Das P, Smithson LA, Fauq A, Fan X, Crain BJ, Price DL, Golde TE, Eberhart CG, Wong PC.

J Biol Chem. 2007 Nov 2;282(44):32264-73. Epub 2007 Sep 7.

2.

Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.

Martone RL, Zhou H, Atchison K, Comery T, Xu JZ, Huang X, Gong X, Jin M, Kreft A, Harrison B, Mayer SC, Aschmies S, Gonzales C, Zaleska MM, Riddell DR, Wagner E, Lu P, Sun SC, Sonnenberg-Reines J, Oganesian A, Adkins K, Leach MW, Clarke DW, Huryn D, Abou-Gharbia M, Magolda R, Bard J, Frick G, Raje S, Forlow SB, Balliet C, Burczynski ME, Reinhart PH, Wan HI, Pangalos MN, Jacobsen JS.

J Pharmacol Exp Ther. 2009 Nov;331(2):598-608. doi: 10.1124/jpet.109.152975. Epub 2009 Aug 11.

3.

Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities.

Li T, Wen H, Brayton C, Laird FM, Ma G, Peng S, Placanica L, Wu TC, Crain BJ, Price DL, Eberhart CG, Wong PC.

J Neurosci. 2007 Oct 3;27(40):10849-59.

4.

Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific presenilin mutations.

Futai E, Yagishita S, Ishiura S.

J Biol Chem. 2009 May 8;284(19):13013-22. doi: 10.1074/jbc.M807653200. Epub 2009 Mar 2.

5.

Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design.

Wei P, Walls M, Qiu M, Ding R, Denlinger RH, Wong A, Tsaparikos K, Jani JP, Hosea N, Sands M, Randolph S, Smeal T.

Mol Cancer Ther. 2010 Jun;9(6):1618-28. doi: 10.1158/1535-7163.MCT-10-0034. Epub 2010 Jun 8.

6.

Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model.

Efferson CL, Winkelmann CT, Ware C, Sullivan T, Giampaoli S, Tammam J, Patel S, Mesiti G, Reilly JF, Gibson RE, Buser C, Yeatman T, Coppola D, Winter C, Clark EA, Draetta GF, Strack PR, Majumder PK.

Cancer Res. 2010 Mar 15;70(6):2476-84. doi: 10.1158/0008-5472.CAN-09-3114. Epub 2010 Mar 2.

7.

γ-Secretase-regulated mechanisms similar to notch signaling may play a role in signaling events, including APP signaling, which leads to Alzheimer's disease.

Nakayama K, Nagase H, Koh CS, Ohkawara T.

Cell Mol Neurobiol. 2011 Aug;31(6):887-900. doi: 10.1007/s10571-011-9688-z. Epub 2011 Apr 23. Review.

PMID:
21516353
8.

Presenilin/gamma-secretase-mediated cleavage regulates association of leukocyte-common antigen-related (LAR) receptor tyrosine phosphatase with beta-catenin.

Haapasalo A, Kim DY, Carey BW, Turunen MK, Pettingell WH, Kovacs DM.

J Biol Chem. 2007 Mar 23;282(12):9063-72. Epub 2007 Jan 26.

9.

Activity of gamma-secretase on substrates other than APP.

Lleó A.

Curr Top Med Chem. 2008;8(1):9-16. Review.

PMID:
18220928
10.

Unnatural amino acid-substituted (hydroxyethyl)urea peptidomimetics inhibit gamma-secretase and promote the neuronal differentiation of neuroblastoma cells.

Liao YF, Wang BJ, Hsu WM, Lee H, Liao CY, Wu SY, Cheng HT, Hu MK.

Mol Pharmacol. 2007 Feb;71(2):588-601. Epub 2006 Nov 14.

11.

Interleukin-1 receptor type 1 is a substrate for gamma-secretase-dependent regulated intramembrane proteolysis.

Elzinga BM, Twomey C, Powell JC, Harte F, McCarthy JV.

J Biol Chem. 2009 Jan 16;284(3):1394-409. doi: 10.1074/jbc.M803108200. Epub 2008 Nov 7.

12.

gamma-Secretase modulators.

Wolfe MS.

Curr Alzheimer Res. 2007 Dec;4(5):571-3. Review.

PMID:
18220525
13.

Synthetic lethality through combined Notch-epidermal growth factor receptor pathway inhibition in basal-like breast cancer.

Dong Y, Li A, Wang J, Weber JD, Michel LS.

Cancer Res. 2010 Jul 1;70(13):5465-74. doi: 10.1158/0008-5472.CAN-10-0173. Epub 2010 Jun 22.

14.

Evidence that gamma-secretase-mediated Notch signaling induces neuronal cell death via the nuclear factor-kappaB-Bcl-2-interacting mediator of cell death pathway in ischemic stroke.

Arumugam TV, Cheng YL, Choi Y, Choi YH, Yang S, Yun YK, Park JS, Yang DK, Thundyil J, Gelderblom M, Karamyan VT, Tang SC, Chan SL, Magnus T, Sobey CG, Jo DG.

Mol Pharmacol. 2011 Jul;80(1):23-31. doi: 10.1124/mol.111.071076. Epub 2011 Mar 30. Erratum in: Mol Pharmacol. 2011 Sep;80(3):550.

15.

Gamma-secretase and the intramembrane proteolysis of Notch.

Jorissen E, De Strooper B.

Curr Top Dev Biol. 2010;92:201-30. doi: 10.1016/S0070-2153(10)92006-1. Review.

PMID:
20816396
16.

Notch signaling is required for exocrine regeneration after acute pancreatitis.

Siveke JT, Lubeseder-Martellato C, Lee M, Mazur PK, Nakhai H, Radtke F, Schmid RM.

Gastroenterology. 2008 Feb;134(2):544-55. doi: 10.1053/j.gastro.2007.11.003. Epub 2007 Nov 4.

PMID:
18242220
17.

Signal integration during development: mechanisms of EGFR and Notch pathway function and cross-talk.

Doroquez DB, Rebay I.

Crit Rev Biochem Mol Biol. 2006 Nov-Dec;41(6):339-85. Review.

PMID:
17092823
18.

Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization.

Vooijs M, Schroeter EH, Pan Y, Blandford M, Kopan R.

J Biol Chem. 2004 Dec 3;279(49):50864-73. Epub 2004 Sep 23.

19.

The insulin-like growth factor 1 (IGF-1) receptor is a substrate for gamma-secretase-mediated intramembrane proteolysis.

McElroy B, Powell JC, McCarthy JV.

Biochem Biophys Res Commun. 2007 Jul 13;358(4):1136-41. Epub 2007 May 21.

PMID:
17524361
20.

Notch signaling in breast cancer and tumor angiogenesis: cross-talk and therapeutic potentials.

Shi W, Harris AL.

J Mammary Gland Biol Neoplasia. 2006 Jan;11(1):41-52. Review.

PMID:
16947085

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