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Items: 1 to 20 of 77

1.

Isoforms of alanine aminotransferases in human tissues and serum--differential tissue expression using novel antibodies.

Lindblom P, Rafter I, Copley C, Andersson U, Hedberg JJ, Berg AL, Samuelsson A, Hellmold H, Cotgreave I, Glinghammar B.

Arch Biochem Biophys. 2007 Oct 1;466(1):66-77. Epub 2007 Aug 11.

PMID:
17826732
2.

Detection of the mitochondrial and catalytically active alanine aminotransferase in human tissues and plasma.

Glinghammar B, Rafter I, Lindström AK, Hedberg JJ, Andersson HB, Lindblom P, Berg AL, Cotgreave I.

Int J Mol Med. 2009 May;23(5):621-31.

PMID:
19360321
3.

Isoform-specific alanine aminotransferase measurement can distinguish hepatic from extrahepatic injury in humans.

Rafter I, Gråberg T, Kotronen A, Strömmer L, Mattson CM, Kim RW, Ehrenborg E, Andersson HB, Yki-Järvinen H, Schuppe-Koistinen I, Ekblom B, Cotgreave I, Glinghammar B.

Int J Mol Med. 2012 Nov;30(5):1241-9. doi: 10.3892/ijmm.2012.1106. Epub 2012 Aug 23.

PMID:
22922605
4.

Murine alanine aminotransferase: cDNA cloning, functional expression, and differential gene regulation in mouse fatty liver.

Jadhao SB, Yang RZ, Lin Q, Hu H, Anania FA, Shuldiner AR, Gong DW.

Hepatology. 2004 May;39(5):1297-302. Erratum in: Hepatology. 2004 Jul;40(1):269. Jadaho Sanjay B [corrected to Jadhao Sanjay B].

PMID:
15122758
5.

Determination of enzymatic source of alanine aminotransferase activity in serum from dogs with liver injury.

Miyazaki M, Rosenblum JS, Kasahara Y, Nakagawa I, Patricelli MP.

J Pharmacol Toxicol Methods. 2009 Nov-Dec;60(3):307-15. doi: 10.1016/j.vascn.2009.09.001. Epub 2009 Sep 11.

PMID:
19748590
6.

cDNA cloning, expression, purification, distribution, and characterization of biologically active canine alanine aminotransferase-1.

Rajamohan F, Nelms L, Joslin DL, Lu B, Reagan WJ, Lawton M.

Protein Expr Purif. 2006 Jul;48(1):81-9. Epub 2006 Jan 30.

PMID:
16495081
7.

Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity.

Yang RZ, Park S, Reagan WJ, Goldstein R, Zhong S, Lawton M, Rajamohan F, Qian K, Liu L, Gong DW.

Hepatology. 2009 Feb;49(2):598-607. doi: 10.1002/hep.22657.

8.

Paralogous ALT1 and ALT2 retention and diversification have generated catalytically active and inactive aminotransferases in Saccharomyces cerevisiae.

Peñalosa-Ruiz G, Aranda C, Ongay-Larios L, Colon M, Quezada H, Gonzalez A.

PLoS One. 2012;7(9):e45702. doi: 10.1371/journal.pone.0045702. Epub 2012 Sep 25.

9.

Alanine aminotransferase regulation by androgens in non-hepatic tissues.

Coss CC, Bauler M, Narayanan R, Miller DD, Dalton JT.

Pharm Res. 2012 Apr;29(4):1046-56. doi: 10.1007/s11095-011-0649-5. Epub 2011 Dec 14.

PMID:
22167351
10.

Expression, purification, and initial characterization of human alanine aminotransferase (ALT) isoenzyme 1 and 2 in High-five insect cells.

Liu L, Zhong S, Yang R, Hu H, Yu D, Zhu D, Hua Z, Shuldiner AR, Goldstein R, Reagan WJ, Gong DW.

Protein Expr Purif. 2008 Aug;60(2):225-31. doi: 10.1016/j.pep.2008.04.006. Epub 2008 Apr 26.

11.

Development of monoclonal antibodies and immunochromatographic lateral flow device for rapid test of alanine aminotransferase isoenzyme 1.

Hu X, Cheng S, Liu X, Li J, Zheng W, Lu G, Zhang J, Zheng J, Zhang J.

Protein Expr Purif. 2016 Mar;119:94-101. doi: 10.1016/j.pep.2015.11.016. Epub 2015 Nov 22.

PMID:
26611609
12.

Hepatic ALT isoenzymes are elevated in gluconeogenic conditions including diabetes and suppressed by insulin at the protein level.

Qian K, Zhong S, Xie K, Yu D, Yang R, Gong DW.

Diabetes Metab Res Rev. 2015 Sep;31(6):562-71. doi: 10.1002/dmrr.2655. Epub 2015 Jun 17.

13.

[Expression of recombinant human alanine aminotransferase (ALT) isoenzyme 2 and preparation of anti-ALT2 monoclonal antibody].

Ge C, Xian YL, Liao HM, Bao YG, Ye XZ, Li YM, Xia HZ.

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2010 Dec;26(12):1232-4, 1237. Chinese.

PMID:
21138690
14.

Increased hepatic expression is a major determinant of serum alanine aminotransferase elevation in mice with nonalcoholic steatohepatitis.

Liu R, Pan X, Whitington PF.

Liver Int. 2009 Mar;29(3):337-43. doi: 10.1111/j.1478-3231.2008.01862.x. Epub 2008 Aug 14.

PMID:
18710424
15.

ALT1-encoded alanine aminotransferase plays a central role in the metabolism of alanine in Saccharomyces cerevisiae.

García-Campusano F, Anaya VH, Robledo-Arratia L, Quezada H, Hernández H, Riego L, González A.

Can J Microbiol. 2009 Apr;55(4):368-74. doi: 10.1139/w08-150.

PMID:
19396236
16.

cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase.

Yang RZ, Blaileanu G, Hansen BC, Shuldiner AR, Gong DW.

Genomics. 2002 Mar;79(3):445-50.

PMID:
11863375
17.

Activating transcription factor 4 mediates up-regulation of alanine aminotransferase 2 gene expression under metabolic stress.

Salgado MC, Metón I, Anemaet IG, Baanante IV.

Biochim Biophys Acta. 2014;1839(4):288-96. doi: 10.1016/j.bbagrm.2014.01.005. Epub 2014 Jan 10.

PMID:
24418603
18.

The peroxisome proliferator-activated receptor α agonist, AZD4619, induces alanine aminotransferase-1 gene and protein expression in human, but not in rat hepatocytes: Correlation with serum ALT levels.

Thulin P, Bamberg K, Buler M, Dahl B, Glinghammar B.

Int J Mol Med. 2016 Sep;38(3):961-8. doi: 10.3892/ijmm.2016.2681. Epub 2016 Jul 14.

PMID:
27430334
19.

PPARalpha regulates the hepatotoxic biomarker alanine aminotransferase (ALT1) gene expression in human hepatocytes.

Thulin P, Rafter I, Stockling K, Tomkiewicz C, Norjavaara E, Aggerbeck M, Hellmold H, Ehrenborg E, Andersson U, Cotgreave I, Glinghammar B.

Toxicol Appl Pharmacol. 2008 Aug 15;231(1):1-9. doi: 10.1016/j.taap.2008.03.007. Epub 2008 Mar 26.

PMID:
18455211
20.

Metabolic adaptive ALT isoenzyme response in livers of C57/BL6 mice treated with dexamethasone.

Reagan WJ, Yang RZ, Park S, Goldstein R, Brees D, Gong DW.

Toxicol Pathol. 2012 Dec;40(8):1117-27. doi: 10.1177/0192623312447550. Epub 2012 May 18.

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