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Items: 1 to 20 of 90

1.

Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells.

Nakano I, Masterman-Smith M, Saigusa K, Paucar AA, Horvath S, Shoemaker L, Watanabe M, Negro A, Bajpai R, Howes A, Lelievre V, Waschek JA, Lazareff JA, Freije WA, Liau LM, Gilbertson RJ, Cloughesy TF, Geschwind DH, Nelson SF, Mischel PS, Terskikh AV, Kornblum HI.

J Neurosci Res. 2008 Jan;86(1):48-60.

PMID:
17722061
2.

Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway.

Nakano I, Joshi K, Visnyei K, Hu B, Watanabe M, Lam D, Wexler E, Saigusa K, Nakamura Y, Laks DR, Mischel PS, Viapiano M, Kornblum HI.

Neuro Oncol. 2011 Jun;13(6):622-34. doi: 10.1093/neuonc/nor023. Epub 2011 May 9.

3.

Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in human astrocytomas.

Marie SK, Okamoto OK, Uno M, Hasegawa AP, Oba-Shinjo SM, Cohen T, Camargo AA, Kosoy A, Carlotti CG Jr, Toledo S, Moreira-Filho CA, Zago MA, Simpson AJ, Caballero OL.

Int J Cancer. 2008 Feb 15;122(4):807-15.

4.

Methods for analysis of brain tumor stem cell and neural stem cell self-renewal.

Nakano I, Kornblum HI.

Methods Mol Biol. 2009;568:37-56. doi: 10.1007/978-1-59745-280-9_4.

PMID:
19582420
5.

MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells.

Joshi K, Banasavadi-Siddegowda Y, Mo X, Kim SH, Mao P, Kig C, Nardini D, Sobol RW, Chow LM, Kornblum HI, Waclaw R, Beullens M, Nakano I.

Stem Cells. 2013 Jun;31(6):1051-63. doi: 10.1002/stem.1358.

6.

Tumor-specific activation of the C-JUN/MELK pathway regulates glioma stem cell growth in a p53-dependent manner.

Gu C, Banasavadi-Siddegowda YK, Joshi K, Nakamura Y, Kurt H, Gupta S, Nakano I.

Stem Cells. 2013 May;31(5):870-81. doi: 10.1002/stem.1322.

7.

Maternal embryonic leucine zipper kinase (MELK) reduces replication stress in glioblastoma cells.

Kig C, Beullens M, Beke L, Van Eynde A, Linders JT, Brehmer D, Bollen M.

J Biol Chem. 2013 Aug 16;288(33):24200-12. doi: 10.1074/jbc.M113.471433. Epub 2013 Jul 8. Retraction in: J Biol Chem. 2017 Aug 4;292(31):12786.

8.

Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation.

Nakano I, Paucar AA, Bajpai R, Dougherty JD, Zewail A, Kelly TK, Kim KJ, Ou J, Groszer M, Imura T, Freije WA, Nelson SF, Sofroniew MV, Wu H, Liu X, Terskikh AV, Geschwind DH, Kornblum HI.

J Cell Biol. 2005 Aug 1;170(3):413-27.

9.

Maternal embryonic leucine zipper kinase enhances gastric cancer progression via the FAK/Paxillin pathway.

Du T, Qu Y, Li J, Li H, Su L, Zhou Q, Yan M, Li C, Zhu Z, Liu B.

Mol Cancer. 2014 May 4;13:100. doi: 10.1186/1476-4598-13-100.

10.

Multi-kinase inhibitor C1 triggers mitotic catastrophe of glioma stem cells mainly through MELK kinase inhibition.

Minata M, Gu C, Joshi K, Nakano-Okuno M, Hong C, Nguyen CH, Kornblum HI, Molla A, Nakano I.

PLoS One. 2014 Apr 16;9(4):e92546. doi: 10.1371/journal.pone.0092546. eCollection 2014.

11.

Maternal embryonic leucine zipper kinase: key kinase for stem cell phenotype in glioma and other cancers.

Ganguly R, Hong CS, Smith LG, Kornblum HI, Nakano I.

Mol Cancer Ther. 2014 Jun;13(6):1393-8. doi: 10.1158/1535-7163.MCT-13-0764. Epub 2014 May 2. Review.

12.

Maternal embryonic leucine zipper kinase is upregulated and required in mammary tumor-initiating cells in vivo.

Hebbard LW, Maurer J, Miller A, Lesperance J, Hassell J, Oshima RG, Terskikh AV.

Cancer Res. 2010 Nov 1;70(21):8863-73. doi: 10.1158/0008-5472.CAN-10-1295. Epub 2010 Sep 22.

13.

Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer.

Pickard MR, Green AR, Ellis IO, Caldas C, Hedge VL, Mourtada-Maarabouni M, Williams GT.

Breast Cancer Res. 2009;11(4):R60. doi: 10.1186/bcr2350. Epub 2009 Aug 11.

14.

Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers.

Gray D, Jubb AM, Hogue D, Dowd P, Kljavin N, Yi S, Bai W, Frantz G, Zhang Z, Koeppen H, de Sauvage FJ, Davis DP.

Cancer Res. 2005 Nov 1;65(21):9751-61.

15.

Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia.

Alachkar H, Mutonga MB, Metzeler KH, Fulton N, Malnassy G, Herold T, Spiekermann K, Bohlander SK, Hiddemann W, Matsuo Y, Stock W, Nakamura Y.

Oncotarget. 2014 Dec 15;5(23):12371-82.

16.

Resistance of colorectal cancer cells to radiation and 5-FU is associated with MELK expression.

Choi S, Ku JL.

Biochem Biophys Res Commun. 2011 Aug 26;412(2):207-13. doi: 10.1016/j.bbrc.2011.07.060. Epub 2011 Jul 22.

PMID:
21806965
17.

Stem cell associated gene expression in glioblastoma multiforme: relationship to survival and the subventricular zone.

Kappadakunnel M, Eskin A, Dong J, Nelson SF, Mischel PS, Liau LM, Ngheimphu P, Lai A, Cloughesy TF, Goldin J, Pope WB.

J Neurooncol. 2010 Feb;96(3):359-67. doi: 10.1007/s11060-009-9983-4. Epub 2009 Aug 5.

19.

MELK expression in ovarian cancer correlates with poor outcome and its inhibition by OTSSP167 abrogates proliferation and viability of ovarian cancer cells.

Kohler RS, Kettelhack H, Knipprath-M├ęszaros AM, Fedier A, Schoetzau A, Jacob F, Heinzelmann-Schwarz V.

Gynecol Oncol. 2017 Apr;145(1):159-166. doi: 10.1016/j.ygyno.2017.02.016. Epub 2017 Feb 14.

20.

MELK and EZH2 Cooperate to Regulate Medulloblastoma Cancer Stem-like Cell Proliferation and Differentiation.

Liu H, Sun Q, Sun Y, Zhang J, Yuan H, Pang S, Qi X, Wang H, Zhang M, Zhang H, Yu C, Gu C.

Mol Cancer Res. 2017 Sep;15(9):1275-1286. doi: 10.1158/1541-7786.MCR-17-0105. Epub 2017 May 23.

PMID:
28536141

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