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Items: 1 to 20 of 190

1.

Mammalian skeletal muscle voltage-gated sodium channels are affected by scorpion depressant "insect-selective" toxins when preconditioned.

Cohen L, Troub Y, Turkov M, Gilles N, Ilan N, Benveniste M, Gordon D, Gurevitz M.

Mol Pharmacol. 2007 Nov;72(5):1220-7. Epub 2007 Aug 24.

2.

NMR structures and activity of a novel alpha-like toxin from the scorpion Leiurus quinquestriatus hebraeus.

Krimm I, Gilles N, Sautière P, Stankiewicz M, Pelhate M, Gordon D, Lancelin JM.

J Mol Biol. 1999 Jan 29;285(4):1749-63.

PMID:
9917409
3.

Genetic polymorphism and expression of a highly potent scorpion depressant toxin enable refinement of the effects on insect Na channels and illuminate the key role of Asn-58.

Strugatsky D, Zilberberg N, Stankiewicz M, Ilan N, Turkov M, Cohen L, Pelhate M, Gilles N, Gordon D, Gurevitz M.

Biochemistry. 2005 Jun 28;44(25):9179-87.

PMID:
15966742
4.

Combinatorial interaction of scorpion toxins Lqh-2, Lqh-3, and LqhalphaIT with sodium channel receptor sites-3.

Leipold E, Lu S, Gordon D, Hansel A, Heinemann SH.

Mol Pharmacol. 2004 Mar;65(3):685-91.

5.

Modulation of cloned skeletal muscle sodium channels by the scorpion toxins Lqh II, Lqh III, and Lqh alphaIT.

Chen H, Gordon D, Heinemann SH.

Pflugers Arch. 2000 Feb;439(4):423-32.

PMID:
10678738
6.

Positions under positive selection--key for selectivity and potency of scorpion alpha-toxins.

Weinberger H, Moran Y, Gordon D, Turkov M, Kahn R, Gurevitz M.

Mol Biol Evol. 2010 May;27(5):1025-34. doi: 10.1093/molbev/msp310. Epub 2009 Dec 17.

PMID:
20018978
7.

New toxins acting on sodium channels from the scorpion Leiurus quinquestriatus hebraeus suggest a clue to mammalian vs insect selectivity.

Sautière P, Cestèle S, Kopeyan C, Martinage A, Drobecq H, Doljansky Y, Gordon D.

Toxicon. 1998 Aug;36(8):1141-54.

PMID:
9690781
8.

Characterization of scorpion alpha-like toxin group using two new toxins from the scorpion Leiurus quinquestriatus hebraeus.

Hamon A, Gilles N, Sautière P, Martinage A, Kopeyan C, Ulens C, Tytgat J, Lancelin JM, Gordon D.

Eur J Biochem. 2002 Aug;269(16):3920-33.

9.

Mapping of scorpion toxin receptor sites at voltage-gated sodium channels.

Gurevitz M.

Toxicon. 2012 Sep 15;60(4):502-11. doi: 10.1016/j.toxicon.2012.03.022. Epub 2012 Apr 4.

PMID:
22694883
10.

Isolation and characterization of two novel scorpion toxins: The alpha-toxin-like CeII8, specific for Na(v)1.7 channels and the classical anti-mammalian CeII9, specific for Na(v)1.4 channels.

Vandendriessche T, Olamendi-Portugal T, Zamudio FZ, Possani LD, Tytgat J.

Toxicon. 2010 Sep 15;56(4):613-23. doi: 10.1016/j.toxicon.2010.06.008. Epub 2010 Jun 19.

PMID:
20600228
11.

NMR analysis of interaction of LqhalphaIT scorpion toxin with a peptide corresponding to the D4/S3-S4 loop of insect para voltage-gated sodium channel.

Schnur E, Turkov M, Kahn R, Gordon D, Gurevitz M, Anglister J.

Biochemistry. 2008 Jan 22;47(3):911-21. Epub 2007 Dec 23.

PMID:
18154318
12.

The depressant scorpion neurotoxin LqqIT2 selectively modulates the insect voltage-gated sodium channel.

Bosmans F, Martin-Eauclaire MF, Tytgat J.

Toxicon. 2005 Mar 15;45(4):501-7. Epub 2005 Jan 20.

PMID:
15733572
13.

Scorpion toxins affecting sodium current inactivation bind to distinct homologous receptor sites on rat brain and insect sodium channels.

Gordon D, Martin-Eauclaire MF, Cestèle S, Kopeyan C, Carlier E, Khalifa RB, Pelhate M, Rochat H.

J Biol Chem. 1996 Apr 5;271(14):8034-45.

14.

Substitutions in the domain III voltage-sensing module enhance the sensitivity of an insect sodium channel to a scorpion beta-toxin.

Song W, Du Y, Liu Z, Luo N, Turkov M, Gordon D, Gurevitz M, Goldin AL, Dong K.

J Biol Chem. 2011 May 6;286(18):15781-8. doi: 10.1074/jbc.M110.217000. Epub 2011 Mar 15.

15.

A scorpion alpha-like toxin that is active on insects and mammals reveals an unexpected specificity and distribution of sodium channel subtypes in rat brain neurons.

Gilles N, Blanchet C, Shichor I, Zaninetti M, Lotan I, Bertrand D, Gordon D.

J Neurosci. 1999 Oct 15;19(20):8730-9.

16.

A scorpion venom neurotoxin paralytic to insects that affects sodium current inactivation: purification, primary structure, and mode of action.

Eitan M, Fowler E, Herrmann R, Duval A, Pelhate M, Zlotkin E.

Biochemistry. 1990 Jun 26;29(25):5941-7.

PMID:
2383565
17.

An 'Old World' scorpion beta-toxin that recognizes both insect and mammalian sodium channels.

Gordon D, Ilan N, Zilberberg N, Gilles N, Urbach D, Cohen L, Karbat I, Froy O, Gaathon A, Kallen RG, Benveniste M, Gurevitz M.

Eur J Biochem. 2003 Jun;270(12):2663-70.

18.

X-ray structure and mutagenesis of the scorpion depressant toxin LqhIT2 reveals key determinants crucial for activity and anti-insect selectivity.

Karbat I, Turkov M, Cohen L, Kahn R, Gordon D, Gurevitz M, Frolow F.

J Mol Biol. 2007 Feb 16;366(2):586-601. Epub 2006 Nov 10.

PMID:
17166514
19.

Scorpion alpha-like toxins, toxic to both mammals and insects, differentially interact with receptor site 3 on voltage-gated sodium channels in mammals and insects.

Cestèle S, Stankiewicz M, Mansuelle P, De Waard M, Dargent B, Gilles N, Pelhate M, Rochat H, Martin-Eauclaire MF, Gordon D.

Eur J Neurosci. 1999 Mar;11(3):975-85.

PMID:
10103091
20.

Scorpion alpha and alpha-like toxins differentially interact with sodium channels in mammalian CNS and periphery.

Gilles N, Chen H, Wilson H, Le Gall F, Montoya G, Molgo J, Schönherr R, Nicholson G, Heinemann SH, Gordon D.

Eur J Neurosci. 2000 Aug;12(8):2823-32.

PMID:
10971624

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