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Items: 1 to 20 of 82

1.

Monoglyceride lipase as an enzyme hydrolyzing 2-arachidonoylglycerol.

Saario SM, Laitinen JT.

Chem Biodivers. 2007 Aug;4(8):1903-13. Review. No abstract available.

PMID:
17712832
2.

Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Å resolution.

Schalk-Hihi C, Schubert C, Alexander R, Bayoumy S, Clemente JC, Deckman I, DesJarlais RL, Dzordzorme KC, Flores CM, Grasberger B, Kranz JK, Lewandowski F, Liu L, Ma H, Maguire D, Macielag MJ, McDonnell ME, Mezzasalma Haarlander T, Miller R, Milligan C, Reynolds C, Kuo LC.

Protein Sci. 2011 Apr;20(4):670-83. doi: 10.1002/pro.596. Epub 2011 Mar 1.

3.

Fatty pain cures.

Imming P.

Chem Biol. 2007 Dec;14(12):1311-2.

4.

Cell biology. Anatomy of prostaglandin signals.

Stella N.

Science. 2011 Nov 11;334(6057):768-9. doi: 10.1126/science.1215389. No abstract available.

5.

Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling.

Labar G, Bauvois C, Borel F, Ferrer JL, Wouters J, Lambert DM.

Chembiochem. 2010 Jan 25;11(2):218-27. doi: 10.1002/cbic.200900621.

PMID:
19957260
6.

2-AG + 2 new players = forecast for therapeutic advances.

Marrs W, Stella N.

Chem Biol. 2007 Dec;14(12):1309-11.

7.
8.

Discovery and development of endocannabinoid-hydrolyzing enzyme inhibitors.

Minkkilä A, Saario S, Nevalainen T.

Curr Top Med Chem. 2010;10(8):828-58. Review.

PMID:
20370710
9.

Biosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol.

Ueda N, Tsuboi K, Uyama T, Ohnishi T.

Biofactors. 2011 Jan-Feb;37(1):1-7. doi: 10.1002/biof.131. Epub 2010 Nov 29. Review.

PMID:
21328621
10.

Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons.

Marrs WR, Horne EA, Ortega-Gutierrez S, Cisneros JA, Xu C, Lin YH, Muccioli GG, Lopez-Rodriguez ML, Stella N.

J Biol Chem. 2011 Aug 19;286(33):28723-8. doi: 10.1074/jbc.M110.202853. Epub 2011 Jun 10.

11.

Brain monoglyceride lipase participating in endocannabinoid inactivation.

Dinh TP, Carpenter D, Leslie FM, Freund TF, Katona I, Sensi SL, Kathuria S, Piomelli D.

Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10819-24. Epub 2002 Jul 22. Erratum in: Proc Natl Acad Sci U S A 2002 Oct 15;99(21):13961.

12.

Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes.

Saario SM, Savinainen JR, Laitinen JT, Järvinen T, Niemi R.

Biochem Pharmacol. 2004 Apr 1;67(7):1381-7.

PMID:
15013854
13.

Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation.

Nomura DK, Morrison BE, Blankman JL, Long JZ, Kinsey SG, Marcondes MC, Ward AM, Hahn YK, Lichtman AH, Conti B, Cravatt BF.

Science. 2011 Nov 11;334(6057):809-13. doi: 10.1126/science.1209200. Epub 2011 Oct 20.

14.

Possible inhibitory roles of endogenous 2-arachidonoylglycerol during corticotropin-releasing factor-induced activation of central sympatho-adrenomedullary outflow in anesthetized rats.

Shimizu T, Lu L, Yokotani K.

Eur J Pharmacol. 2010 Sep 1;641(1):54-60. doi: 10.1016/j.ejphar.2010.05.007. Epub 2010 May 25.

PMID:
20519139
15.

S-Arachidonoyl-2-thioglycerol synthesis and use for fluorimetric and colorimetric assays of monoacylglycerol lipase.

Casida JE, Gulevich AG, Sarpong R, Bunnelle EM.

Bioorg Med Chem. 2010 Mar 1;18(5):1942-7. doi: 10.1016/j.bmc.2010.01.034. Epub 2010 Jan 18.

PMID:
20138526
16.

The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications.

Lambert DM, Fowler CJ.

J Med Chem. 2005 Aug 11;48(16):5059-87. Review. No abstract available.

PMID:
16078824
17.

The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors.

Savinainen JR, Saario SM, Laitinen JT.

Acta Physiol (Oxf). 2012 Feb;204(2):267-76. doi: 10.1111/j.1748-1716.2011.02280.x. Epub 2011 Apr 22. Review. Erratum in: Acta Physiol (Oxf). 2012 Mar;204(3):460.

18.

Hydrolysis of 2-arachidonoylglycerol in Tetrahymena thermophila. Identification and partial characterization of a Monoacylglycerol Lipase-like enzyme.

Evagorou A, Anagnostopoulos D, Farmaki E, Siafaka-Kapadai A.

Eur J Protistol. 2010 Nov;46(4):289-97. doi: 10.1016/j.ejop.2010.06.001.

PMID:
20889319
19.

Endogenously generated 2-arachidonoylglycerol plays an inhibitory role in bombesin-induced activation of central adrenomedullary outflow in rats.

Shimizu T, Lu L, Yokotani K.

Eur J Pharmacol. 2011 May 11;658(2-3):123-31. doi: 10.1016/j.ejphar.2011.02.023. Epub 2011 Mar 1.

PMID:
21371452
20.

Synapse type-independent degradation of the endocannabinoid 2-arachidonoylglycerol after retrograde synaptic suppression.

Tanimura A, Uchigashima M, Yamazaki M, Uesaka N, Mikuni T, Abe M, Hashimoto K, Watanabe M, Sakimura K, Kano M.

Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12195-200. doi: 10.1073/pnas.1204404109. Epub 2012 Jul 10.

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