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Items: 1 to 20 of 87

1.

Metabolism of benzo[a]pyrene in human bronchoalveolar H358 cells using liquid chromatography-mass spectrometry.

Jiang H, Gelhaus SL, Mangal D, Harvey RG, Blair IA, Penning TM.

Chem Res Toxicol. 2007 Sep;20(9):1331-41. Epub 2007 Aug 17.

2.

Regulation of benzo[a]pyrene-mediated DNA- and glutathione-adduct formation by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human lung cells.

Gelhaus SL, Harvey RG, Penning TM, Blair IA.

Chem Res Toxicol. 2011 Jan 14;24(1):89-98. doi: 10.1021/tx100297z. Epub 2010 Oct 28.

4.
6.

Aldo-keto reductase- and cytochrome P450-dependent formation of benzo[a]pyrene-derived DNA adducts in human bronchoalveolar cells.

Ruan Q, Gelhaus SL, Penning TM, Harvey RG, Blair IA.

Chem Res Toxicol. 2007 Mar;20(3):424-31. Epub 2007 Feb 13.

PMID:
17295519
7.

Aldo-keto reductases protect lung adenocarcinoma cells from the acute toxicity of B[a]P-7,8-trans-dihydrodiol.

Abedin Z, Sen S, Field J.

Chem Res Toxicol. 2012 Jan 13;25(1):113-21. doi: 10.1021/tx200272v. Epub 2011 Nov 16.

8.
9.

Inflammatory mediators accelerate metabolism of benzo[a]pyrene in rat alveolar type II cells: the role of enhanced cytochrome P450 1B1 expression.

Smerdová L, Neča J, Svobodová J, Topinka J, Schmuczerová J, Kozubík A, Machala M, Vondráček J.

Toxicology. 2013 Dec 6;314(1):30-8. doi: 10.1016/j.tox.2013.09.001. Epub 2013 Sep 8.

PMID:
24025706
10.

Importance of CYP1A1 and CYP1B1 in bioactivation of benzo[a]pyrene in human lung cell lines.

Uppstad H, Øvrebø S, Haugen A, Mollerup S.

Toxicol Lett. 2010 Feb 1;192(2):221-8. doi: 10.1016/j.toxlet.2009.10.025. Epub 2009 Oct 30.

PMID:
19879933
11.

Induction of CYP1A1 and CYP1B1 by benzo(k)fluoranthene and benzo(a)pyrene in T-47D human breast cancer cells: roles of PAH interactions and PAH metabolites.

Spink DC, Wu SJ, Spink BC, Hussain MM, Vakharia DD, Pentecost BT, Kaminsky LS.

Toxicol Appl Pharmacol. 2008 Feb 1;226(3):213-24. Epub 2007 Sep 5.

12.

Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1.

Kim JH, Stansbury KH, Walker NJ, Trush MA, Strickland PT, Sutter TR.

Carcinogenesis. 1998 Oct;19(10):1847-53. Erratum in: Carcinogenesis 1999 Mar;20(3):515.

PMID:
9806168
13.

Specificity of human aldo-keto reductases, NAD(P)H:quinone oxidoreductase, and carbonyl reductases to redox-cycle polycyclic aromatic hydrocarbon diones and 4-hydroxyequilenin-o-quinone.

Shultz CA, Quinn AM, Park JH, Harvey RG, Bolton JL, Maser E, Penning TM.

Chem Res Toxicol. 2011 Dec 19;24(12):2153-66. doi: 10.1021/tx200294c. Epub 2011 Sep 29.

15.

Role of cytochrome P450 enzyme induction in the metabolic activation of benzo[c]phenanthrene in human cell lines and mouse epidermis.

Einolf HJ, Story WT, Marcus CB, Larsen MC, Jefcoate CR, Greenlee WF, Yagi H, Jerina DM, Amin S, Park SS, Gelboin HV, Baird WM.

Chem Res Toxicol. 1997 May;10(5):609-17.

PMID:
9168260
16.
17.

p53 Mutagenesis by benzo[a]pyrene derived radical cations.

Sen S, Bhojnagarwala P, Francey L, Lu D, Penning TM, Field J.

Chem Res Toxicol. 2012 Oct 15;25(10):2117-26. doi: 10.1021/tx300201p. Epub 2012 Aug 9.

18.

Evidence for the aldo-keto reductase pathway of polycyclic aromatic trans-dihydrodiol activation in human lung A549 cells.

Park JH, Mangal D, Tacka KA, Quinn AM, Harvey RG, Blair IA, Penning TM.

Proc Natl Acad Sci U S A. 2008 May 13;105(19):6846-51. doi: 10.1073/pnas.0802776105. Epub 2008 May 12.

19.

Metabolism and distribution of benzo[a]pyrene-7,8-dione (B[a]P-7,8-dione) in human lung cells by liquid chromatography tandem mass spectrometry: detection of an adenine B[a]P-7,8-dione adduct.

Huang M, Liu X, Basu SS, Zhang L, Kushman ME, Harvey RG, Blair IA, Penning TM.

Chem Res Toxicol. 2012 May 21;25(5):993-1003. doi: 10.1021/tx200463s. Epub 2012 May 1.

20.

Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase.

Shimada T, Gillam EM, Oda Y, Tsumura F, Sutter TR, Guengerich FP, Inoue K.

Chem Res Toxicol. 1999 Jul;12(7):623-9.

PMID:
10409402

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