Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 104


The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis.

Jones RG, Bui T, White C, Madesh M, Krawczyk CM, Lindsten T, Hawkins BJ, Kubek S, Frauwirth KA, Wang YL, Conway SJ, Roderick HL, Bootman MD, Shen H, Foskett JK, Thompson CB.

Immunity. 2007 Aug;27(2):268-80. Epub 2007 Aug 9.


Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum.

Oakes SA, Scorrano L, Opferman JT, Bassik MC, Nishino M, Pozzan T, Korsmeyer SJ.

Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):105-10. Epub 2004 Dec 21.


Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members.

Oakes SA, Opferman JT, Pozzan T, Korsmeyer SJ, Scorrano L.

Biochem Pharmacol. 2003 Oct 15;66(8):1335-40. Review.


BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis.

Scorrano L, Oakes SA, Opferman JT, Cheng EH, Sorcinelli MD, Pozzan T, Korsmeyer SJ.

Science. 2003 Apr 4;300(5616):135-9. Epub 2003 Mar 6.


Inhibition of the ER Ca2+ pump forces multidrug-resistant cells deficient in Bak and Bax into necrosis.

Janssen K, Horn S, Niemann MT, Daniel PT, Schulze-Osthoff K, Fischer U.

J Cell Sci. 2009 Dec 15;122(Pt 24):4481-91. doi: 10.1242/jcs.055772. Epub 2009 Nov 17.


Bax and Bak promote apoptosis by modulating endoplasmic reticular and mitochondrial Ca2+ stores.

Nutt LK, Pataer A, Pahler J, Fang B, Roth J, McConkey DJ, Swisher SG.

J Biol Chem. 2002 Mar 15;277(11):9219-25. Epub 2001 Dec 6.


Endoplasmic reticulum stress in the proapoptotic action of edelfosine in solid tumor cells.

Nieto-Miguel T, Fonteriz RI, Vay L, Gajate C, López-Hernández S, Mollinedo F.

Cancer Res. 2007 Nov 1;67(21):10368-78.


Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis.

Zong WX, Li C, Hatzivassiliou G, Lindsten T, Yu QC, Yuan J, Thompson CB.

J Cell Biol. 2003 Jul 7;162(1):59-69.


Critical role for mitochondrial oxidative phosphorylation in the activation of tumor suppressors Bax and Bak.

Tomiyama A, Serizawa S, Tachibana K, Sakurada K, Samejima H, Kuchino Y, Kitanaka C.

J Natl Cancer Inst. 2006 Oct 18;98(20):1462-73.


Deficiency in apoptotic effectors Bax and Bak reveals an autophagic cell death pathway initiated by photodamage to the endoplasmic reticulum.

Buytaert E, Callewaert G, Vandenheede JR, Agostinis P.

Autophagy. 2006 Jul-Sep;2(3):238-40. Epub 2006 Jul 22. Review.


Bak compensated for Bax in p53-null cells to release cytochrome c for the initiation of mitochondrial signaling during Withanolide D-induced apoptosis.

Mondal S, Bhattacharya K, Mallick A, Sangwan R, Mandal C.

PLoS One. 2012;7(3):e34277. doi: 10.1371/journal.pone.0034277. Epub 2012 Mar 29.


Suppression of PI3K/Akt signaling by synthetic bichalcone analog TSWU-CD4 induces ER stress- and Bax/Bak-mediated apoptosis of cancer cells.

Lin ML, Chen SS, Huang RY, Lu YC, Liao YR, Reddy MV, Lee CC, Wu TS.

Apoptosis. 2014 Nov;19(11):1637-53. doi: 10.1007/s10495-014-1031-y.


BI-1 regulates endoplasmic reticulum Ca2+ homeostasis downstream of Bcl-2 family proteins.

Xu C, Xu W, Palmer AE, Reed JC.

J Biol Chem. 2008 Apr 25;283(17):11477-84. doi: 10.1074/jbc.M708385200. Epub 2008 Feb 25.


Role of endoplasmic reticulum depletion and multidomain proapoptotic BAX and BAK proteins in shaping cell death after hypericin-mediated photodynamic therapy.

Buytaert E, Callewaert G, Hendrickx N, Scorrano L, Hartmann D, Missiaen L, Vandenheede JR, Heirman I, Grooten J, Agostinis P.

FASEB J. 2006 Apr;20(6):756-8. Epub 2006 Feb 2.


Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins.

Brooks C, Wei Q, Feng L, Dong G, Tao Y, Mei L, Xie ZJ, Dong Z.

Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11649-54. Epub 2007 Jul 2.


Impact of the combined loss of BOK, BAX and BAK on the hematopoietic system is slightly more severe than compound loss of BAX and BAK.

Ke F, Grabow S, Kelly GL, Lin A, O'Reilly LA, Strasser A.

Cell Death Dis. 2015 Oct 22;6:e1938. doi: 10.1038/cddis.2015.304.


A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway.

Zamorano S, Rojas-Rivera D, Lisbona F, Parra V, Court FA, Villegas R, Cheng EH, Korsmeyer SJ, Lavandero S, Hetz C.

PLoS One. 2012;7(6):e37782. doi: 10.1371/journal.pone.0037782. Epub 2012 Jun 12.


Mitochondrial apoptosis induced by BH3-only molecules in the exclusive presence of endoplasmic reticular Bak.

Klee M, Pallauf K, Alcalá S, Fleischer A, Pimentel-Muiños FX.

EMBO J. 2009 Jun 17;28(12):1757-68. doi: 10.1038/emboj.2009.90. Epub 2009 Apr 2.


Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha.

Hetz C, Bernasconi P, Fisher J, Lee AH, Bassik MC, Antonsson B, Brandt GS, Iwakoshi NN, Schinzel A, Glimcher LH, Korsmeyer SJ.

Science. 2006 Apr 28;312(5773):572-6.

Supplemental Content

Support Center