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17663526,15955702,17705444,20429547,16296784,16087399,11595719,16298526,12778055,23935213,19554734,18690826,25813885,19499915,18159936,17867649,25819334,19070661,22171694,15225730,16704224,18336946,7885077,19891424,1727373,15240546,18314937,15769088,25654690,19417509,15958579,20055167,15544875,11125291,2435417,26513450,24960585,3060267,17226956,16417259,10606261,24901491,15264863,26182432,12856152,19643474,18704409,19364082,14704833,17532091,20222099,19934334,15743178,15501062,22003066,19469529,18959436,19863166,3291765,22168163,16394252,16307811,13129824,21439410,2968779,18468892,17959241,18278853,16984117,20466144,19327045,11853934,18071951,11326743,17226971,19446281,17655275,19459847,18641636,17880166,15782542,18234388,14980540,19175328,16787308,19661298,23683251,15866340,15158968,15839702,19331851,17935268,2968778,17905518,19699247,16275070,8370084,80453,19576253,16469865,18519795,20797419,21756952,17363137,23187462,15174838,15990916,15571383,25722499,21843648,12801231,21819046,16821799,15064445,19127860,9802954,16191416,17207883,3048656,1388633,19252846,12901229,22057500,20162159,18536555,2425743,11338934,21258147,22326503,21822353,9129688,2979791,2570523,15617850,21993223,17392715,16444775,19903151,9192475,15671537,15927340,9177838,19769391,15519609,17357586,17621878,22212902,21761902,25703117,22069744,8397487,19569996,22428156,15387893,16542219,17530025,16861127,15283135,15548877,15051054,23469971,23507041,20201555,17385753,17154485,16618769,20657048,17530026,22465389,22580227,23221098,22155554,29468872,12703211,16243897,15298478,15885853,21034674,17430630,16377176,21368753,24573305,16322102,20496255,9549349,17482133,1563006,20820656,15763642,23253133,19919058,17464275,15801856,8673023,11118047,1457528,16870437,24236714,12886687,14965224,15803155,16869304,2475654,25847766,30068276,22735971,7765070,15820403,17436550,15197300,22155555,17079478,11928224,8740561,19685299,14748665,9177849,15653165,29287255,15366955,28814834,9292397,15279611,23461361,24677743,15271348,26524088,17602528,11162046,16168135,22208984,22245689,22650648,20636185,33966624,17366637,17293111,31593466,14871103,17292060,16900224,20447706,11125289,363260,26403518,12186272,15369396,16376827,16233988,17228885,15844895,22834009,15242245,8553020,8397766,19708822,18494516,12548691,11057331,16153121,17001173,22905345,35214128,33961440,24397286,11727497,20814957,16424916,16039518,2434978,22306430,16952071,22659123,17087271,15876403,35469577,11925748,21142695,24035975,20977221,25914147,32545345,26513646,15898742,23174713,26851520,25455482,23477784,23913142,17214084,10928047,34087447,16414204,15320824,14582121,9575421,25176286,17466589,21391620,23913143,35710136,16532818,26560242,21996055,26079148,26058565,2979064,34635096,14523941,12793897,31189762,1637417,31669121,23399156,15979379,29732446,16323954,25407106,11999171,21481097,16844372,28319221,17350834,22260171,16935749,27706928,24628247,28824201,26965452,16149863,12360278,10690507,19417281,24510148,21784635,20449478,12553069,13129825,12092246,20958218,20705039,31403246,22917246,2059966,15195294,30031619,15261295,29211454,35631384,25738312,17390249,8036894,16622479,24700555,16386903,22564382,16185884,20705017,11562192,36285914,11003162,11498360,36204777,20231381,34334251,31067748,17068501,27762582,19239240,15674484,24898048,29057403,21954061,30288233,17141970,18691086,7947082,25506226,12678771,15664507,20862743,30939768,17097756,29357804,25320865,28412485,20021419,35745573,23682571,17406606,15263944,3204321,1983386,35955648,31958454,31418970,25205656,9484789,28458284,16338425,30165923,2701364,31580248,11195692,18821795,37156134,31909311,28939556,24148240,11731026,2656481,21766411,29441783,33113145,16724057,26810261,23438831,29182932,33179902,21726187,21892324,31483607,34097382,17662604,20954320,28952557,35890212,35516223,11375721,28947977,32856404,18815813,34094177,24186148,2616585,29493023,12934937,36791920,31620224,29057047,15991934,8601570,35128410,31231996,32677650,19408102,31821384,21445732,34206656,15562328,23648945,27416332,35366763,16122231,20391394,31762977,33562376,23496126,29131621,33878368,32652119,29313017,12418880,28399405,31460422,22579276,34427046,19454264,15989600,37004925,35504859,10837595,36262394,26665191,32803765,15838937,35242746,33467465,35528670,29309112,34785315,35143090,34661072,21374022,24493968,1977461,37098237,27339783,34458842,30108828,35051748,32190266,29893499,29765474,33359583,29905493,33367224,2095213,21995320,8547956,30479915,27406612,35865575,2675955,33041742,33133727,34058033,32259092,17187479,17832727,19862972,8811311,21274418,32208715,10234148,4052930,2656472,36974693,8071709,23150805,32021452,6745787,17815843,17812127,27014835,22292755,14686374,35203476,17344821,16096912,35309517,29832118,17151613,10547232,17990827,35823302[uid]

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Guided molecular missiles for tumor-targeting chemotherapy--case studies using the second-generation taxoids as warheads.

Ojima I. Ojima I. Acc Chem Res. 2008 Jan;41(1):108-19. doi: 10.1021/ar700093f. Epub 2007 Jul 31. Acc Chem Res. 2008. PMID: 17663526 Review.

Recent advances in tumor-targeting anticancer drug conjugates.

Jaracz S, Chen J, Kuznetsova LV, Ojima I. Jaracz S, et al. Bioorg Med Chem. 2005 Sep 1;13(17):5043-54. doi: 10.1016/j.bmc.2005.04.084. Bioorg Med Chem. 2005. PMID: 15955702 Review.

Targeted cancer therapy: conferring specificity to cytotoxic drugs.

Chari RV. Chari RV. Acc Chem Res. 2008 Jan;41(1):98-107. doi: 10.1021/ar700108g. Epub 2007 Aug 18. Acc Chem Res. 2008. PMID: 17705444 Review.

Mechanism-based tumor-targeting drug delivery system. Validation of efficient vitamin receptor-mediated endocytosis and drug release.

Chen S, Zhao X, Chen J, Chen J, Kuznetsova L, Wong SS, Ojima I. Chen S, et al. Bioconjug Chem. 2010 May 19;21(5):979-87. doi: 10.1021/bc9005656. Bioconjug Chem. 2010. PMID: 20429547 Free PMC article.

Antibody-cytotoxic agent conjugates for cancer therapy.

Chen J, Jaracz S, Zhao X, Chen S, Ojima I. Chen J, et al. Expert Opin Drug Deliv. 2005 Sep;2(5):873-90. doi: 10.1517/17425247.2.5.873. Expert Opin Drug Deliv. 2005. PMID: 16296784 Review.

Drug-conjugated monoclonal antibodies for the treatment of cancer.

Lambert JM. Lambert JM. Curr Opin Pharmacol. 2005 Oct;5(5):543-9. doi: 10.1016/j.coph.2005.04.017. Curr Opin Pharmacol. 2005. PMID: 16087399 Review.

Tumor targeting by covalent conjugation of a natural fatty acid to paclitaxel.

Bradley MO, Webb NL, Anthony FH, Devanesan P, Witman PA, Hemamalini S, Chander MC, Baker SD, He L, Horwitz SB, Swindell CS. Bradley MO, et al. Clin Cancer Res. 2001 Oct;7(10):3229-38. Clin Cancer Res. 2001. PMID: 11595719

Syntheses and evaluation of novel fatty acid-second-generation taxoid conjugates as promising anticancer agents.

Kuznetsova L, Chen J, Sun L, Wu X, Pepe A, Veith JM, Pera P, Bernacki RJ, Ojima I. Kuznetsova L, et al. Bioorg Med Chem Lett. 2006 Feb 15;16(4):974-7. doi: 10.1016/j.bmcl.2005.10.089. Epub 2005 Nov 18. Bioorg Med Chem Lett. 2006. PMID: 16298526

Development of potent monoclonal antibody auristatin conjugates for cancer therapy.

Doronina SO, Toki BE, Torgov MY, Mendelsohn BA, Cerveny CG, Chace DF, DeBlanc RL, Gearing RP, Bovee TD, Siegall CB, Francisco JA, Wahl AF, Meyer DL, Senter PD. Doronina SO, et al. Nat Biotechnol. 2003 Jul;21(7):778-84. doi: 10.1038/nbt832. Epub 2003 Jun 1. Nat Biotechnol. 2003. PMID: 12778055

Fluorine-Containing Taxoid Anticancer Agents and Their Tumor-Targeted Drug Delivery.

Seitz J, Vineberg JG, Zuniga ES, Ojima I. Seitz J, et al. J Fluor Chem. 2013 Aug 1;152:157-165. doi: 10.1016/j.jfluchem.2013.05.013. J Fluor Chem. 2013. PMID: 23935213 Free PMC article.

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