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Items: 1 to 20 of 99

1.

The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Galpha-interaction face.

Kimple AJ, Willard FS, Giguère PM, Johnston CA, Mocanu V, Siderovski DP.

Biochim Biophys Acta. 2007 Sep;1774(9):1213-20. Epub 2007 Jun 29.

2.

Allosteric inhibition of the regulator of G protein signaling-Galpha protein-protein interaction by CCG-4986.

Roman DL, Blazer LL, Monroy CA, Neubig RR.

Mol Pharmacol. 2010 Sep;78(3):360-5. doi: 10.1124/mol.109.063388. Epub 2010 Jun 7.

3.

A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling proteins.

Blazer LL, Zhang H, Casey EM, Husbands SM, Neubig RR.

Biochemistry. 2011 Apr 19;50(15):3181-92. doi: 10.1021/bi1019622. Epub 2011 Mar 29.

4.

Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay.

Roman DL, Talbot JN, Roof RA, Sunahara RK, Traynor JR, Neubig RR.

Mol Pharmacol. 2007 Jan;71(1):169-75. Epub 2006 Sep 29.

5.

Conformational dynamics of a regulator of G-protein signaling protein reveals a mechanism of allosteric inhibition by a small molecule.

Vashisth H, Storaska AJ, Neubig RR, Brooks CL 3rd.

ACS Chem Biol. 2013 Dec 20;8(12):2778-84. doi: 10.1021/cb400568g. Epub 2013 Oct 24.

6.

Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins.

Blazer LL, Roman DL, Chung A, Larsen MJ, Greedy BM, Husbands SM, Neubig RR.

Mol Pharmacol. 2010 Sep;78(3):524-33. doi: 10.1124/mol.110.065128. Epub 2010 Jun 22.

7.

A covalent peptide inhibitor of RGS4 identified in a focused one-bead, one compound library screen.

Roof RA, Roman DL, Clements ST, Sobczyk-Kojiro K, Blazer LL, Ota S, Mosberg HI, Neubig RR.

BMC Pharmacol. 2009 May 22;9:9. doi: 10.1186/1471-2210-9-9.

8.

Reversible inhibitors of regulators of G-protein signaling identified in a high-throughput cell-based calcium signaling assay.

Storaska AJ, Mei JP, Wu M, Li M, Wade SM, Blazer LL, Sjögren B, Hopkins CR, Lindsley CW, Lin Z, Babcock JJ, McManus OB, Neubig RR.

Cell Signal. 2013 Dec;25(12):2848-55. doi: 10.1016/j.cellsig.2013.09.007. Epub 2013 Sep 14.

10.

Palmitoylation regulates regulator of G-protein signaling (RGS) 16 function. II. Palmitoylation of a cysteine residue in the RGS box is critical for RGS16 GTPase accelerating activity and regulation of Gi-coupled signalling.

Osterhout JL, Waheed AA, Hiol A, Ward RJ, Davey PC, Nini L, Wang J, Milligan G, Jones TL, Druey KM.

J Biol Chem. 2003 May 23;278(21):19309-16. Epub 2003 Mar 17.

11.

Modification and functional inhibition of regulator of G-protein signaling 4 (RGS4) by 4-hydroxy-2-nonenal.

Monroy CA, Doorn JA, Roman DL.

Chem Res Toxicol. 2013 Dec 16;26(12):1832-9. doi: 10.1021/tx400212q. Epub 2013 Nov 14.

12.

Regulators of G-protein signaling (RGS) 4, insertion into model membranes and inhibition of activity by phosphatidic acid.

Ouyang YS, Tu Y, Barker SA, Yang F.

J Biol Chem. 2003 Mar 28;278(13):11115-22. Epub 2003 Jan 21.

13.

Allosteric regulation of GAP activity by phospholipids in regulators of G-protein signaling.

Tu Y, Wilkie TM.

Methods Enzymol. 2004;389:89-105. Review.

PMID:
15313561
14.

Identification of peptides that inhibit regulator of G protein signaling 4 function.

Wang Y, Lee Y, Zhang J, Young KH.

Pharmacology. 2008;82(2):97-104. doi: 10.1159/000138387. Epub 2008 Jun 12.

PMID:
18547979
15.

Regulator of G protein signaling 2 (RGS2) and RGS4 form distinct G protein-dependent complexes with protease activated-receptor 1 (PAR1) in live cells.

Ghil S, McCoy KL, Hepler JR.

PLoS One. 2014 Apr 17;9(4):e95355. doi: 10.1371/journal.pone.0095355. eCollection 2014.

16.

Palmitoylation regulates regulators of G-protein signaling (RGS) 16 function. I. Mutation of amino-terminal cysteine residues on RGS16 prevents its targeting to lipid rafts and palmitoylation of an internal cysteine residue.

Hiol A, Davey PC, Osterhout JL, Waheed AA, Fischer ER, Chen CK, Milligan G, Druey KM, Jones TL.

J Biol Chem. 2003 May 23;278(21):19301-8. Epub 2003 Mar 17.

17.

Structure-based design, synthesis, and activity of peptide inhibitors of RGS4 GAP activity.

Jin Y, Zhong H, Omnaas JR, Neubig RR, Mosberg HI.

Methods Enzymol. 2004;389:266-77.

PMID:
15313571
18.

Selectivity and anti-Parkinson's potential of thiadiazolidinone RGS4 inhibitors.

Blazer LL, Storaska AJ, Jutkiewicz EM, Turner EM, Calcagno M, Wade SM, Wang Q, Huang XP, Traynor JR, Husbands SM, Morari M, Neubig RR.

ACS Chem Neurosci. 2015 Jun 17;6(6):911-9. doi: 10.1021/acschemneuro.5b00063. Epub 2015 Apr 20.

PMID:
25844489
19.

Isolation and characterization of a novel human RGS mutant displaying gain-of-function activity.

Hill C, Brownlie Z, Davey J, Milligan G, Ladds G.

Cell Signal. 2008 Feb;20(2):323-36. Epub 2007 Oct 18.

PMID:
18031991
20.

Structure of the Regulator of G Protein Signaling 8 (RGS8)-Gαq Complex: MOLECULAR BASIS FOR Gα SELECTIVITY.

Taylor VG, Bommarito PA, Tesmer JJ.

J Biol Chem. 2016 Mar 4;291(10):5138-45. doi: 10.1074/jbc.M115.712075. Epub 2016 Jan 11.

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