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Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch.

Amsen D, Antov A, Jankovic D, Sher A, Radtke F, Souabni A, Busslinger M, McCright B, Gridley T, Flavell RA.

Immunity. 2007 Jul;27(1):89-99. Epub 2007 Jul 19.


Notch directly regulates Gata3 expression during T helper 2 cell differentiation.

Fang TC, Yashiro-Ohtani Y, Del Bianco C, Knoblock DM, Blacklow SC, Pear WS.

Immunity. 2007 Jul;27(1):100-10. Epub 2007 Jul 19.


Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells.

Amsen D, Blander JM, Lee GR, Tanigaki K, Honjo T, Flavell RA.

Cell. 2004 May 14;117(4):515-26.


Opposing roles for RelB and Bcl-3 in regulation of T-box expressed in T cells, GATA-3, and Th effector differentiation.

Corn RA, Hunter C, Liou HC, Siebenlist U, Boothby MR.

J Immunol. 2005 Aug 15;175(4):2102-10.


The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3.

Kohu K, Ohmori H, Wong WF, Onda D, Wakoh T, Kon S, Yamashita M, Nakayama T, Kubo M, Satake M.

J Immunol. 2009 Dec 15;183(12):7817-24. doi: 10.4049/jimmunol.0802527.


Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression.

Serre K, Bénézech C, Desanti G, Bobat S, Toellner KM, Bird R, Chan S, Kastner P, Cunningham AF, Maclennan IC, Mohr E.

PLoS One. 2011;6(6):e20731. doi: 10.1371/journal.pone.0020731. Epub 2011 Jun 3.


Genetic reprogramming of primary human T cells reveals functional plasticity in Th cell differentiation.

Sundrud MS, Grill SM, Ni D, Nagata K, Alkan SS, Subramaniam A, Unutmaz D.

J Immunol. 2003 Oct 1;171(7):3542-9.


CD2 facilitates differentiation of CD4 Th cells without affecting Th1/Th2 polarization.

Sasada T, Yang H, Reinherz EL.

J Immunol. 2002 Feb 1;168(3):1113-22.


Functional involvement of dual specificity phosphatase 16 (DUSP16), a c-Jun N-terminal kinase-specific phosphatase, in the regulation of T helper cell differentiation.

Musikacharoen T, Bandow K, Kakimoto K, Kusuyama J, Onishi T, Yoshikai Y, Matsuguchi T.

J Biol Chem. 2011 Jul 15;286(28):24896-905. doi: 10.1074/jbc.M111.245019. Epub 2011 May 25.


Strength of TCR signal determines the costimulatory requirements for Th1 and Th2 CD4+ T cell differentiation.

Tao X, Constant S, Jorritsma P, Bottomly K.

J Immunol. 1997 Dec 15;159(12):5956-63.


Altered Th1 cell differentiation programming by CIITA deficiency.

Patel DR, Kaplan MH, Chang CH.

J Immunol. 2004 Nov 1;173(9):5501-8.


Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions.

Hegazy AN, Peine M, Helmstetter C, Panse I, Fröhlich A, Bergthaler A, Flatz L, Pinschewer DD, Radbruch A, Löhning M.

Immunity. 2010 Jan 29;32(1):116-28. doi: 10.1016/j.immuni.2009.12.004. Epub 2010 Jan 14.


The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes.

Jenner RG, Townsend MJ, Jackson I, Sun K, Bouwman RD, Young RA, Glimcher LH, Lord GM.

Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17876-81. doi: 10.1073/pnas.0909357106. Epub 2009 Oct 5.


The role of Notch in the differentiation of CD4⁺ T helper cells.

Auderset F, Coutaz M, Tacchini-Cottier F.

Curr Top Microbiol Immunol. 2012;360:115-34. doi: 10.1007/82_2012_227. Review.


Notch1 expression on T cells is not required for CD4+ T helper differentiation.

Tacchini-Cottier F, Allenbach C, Otten LA, Radtke F.

Eur J Immunol. 2004 Jun;34(6):1588-96.


Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: a target for STAT6 but not GATA3.

Lee DU, Rao A.

Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):16010-5. Epub 2004 Oct 26.

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