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Items: 1 to 20 of 137

1.

Phosphorylation of human insulin receptor substrate-1 at Serine 629 plays a positive role in insulin signaling.

Luo M, Langlais P, Yi Z, Lefort N, De Filippis EA, Hwang H, Christ-Roberts CY, Mandarino LJ.

Endocrinology. 2007 Oct;148(10):4895-905. Epub 2007 Jul 19.

2.

Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling.

Liberman Z, Eldar-Finkelman H.

J Biol Chem. 2005 Feb 11;280(6):4422-8. Epub 2004 Nov 30.

3.

A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.

Ozes ON, Akca H, Mayo LD, Gustin JA, Maehama T, Dixon JE, Donner DB.

Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4640-5. Epub 2001 Apr 3.

4.

Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells.

Andreozzi F, D'Alessandris C, Federici M, Laratta E, Del Guerra S, Del Prato S, Marchetti P, Lauro R, Perticone F, Sesti G.

Endocrinology. 2004 Jun;145(6):2845-57. Epub 2004 Mar 4.

PMID:
15001544
5.

Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function.

Paz K, Liu YF, Shorer H, Hemi R, LeRoith D, Quan M, Kanety H, Seger R, Zick Y.

J Biol Chem. 1999 Oct 1;274(40):28816-22.

6.

Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation.

Greene MW, Sakaue H, Wang L, Alessi DR, Roth RA.

J Biol Chem. 2003 Mar 7;278(10):8199-211. Epub 2003 Jan 1.

7.

Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance.

Liu YF, Herschkovitz A, Boura-Halfon S, Ronen D, Paz K, Leroith D, Zick Y.

Mol Cell Biol. 2004 Nov;24(21):9668-81.

9.

Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase.

Copps KD, Hançer NJ, Qiu W, White MF.

J Biol Chem. 2016 Apr 15;291(16):8602-17. doi: 10.1074/jbc.M116.714915. Epub 2016 Feb 4.

10.

Identification of insulin receptor substrate 1 serine/threonine phosphorylation sites using mass spectrometry analysis: regulatory role of serine 1223.

Luo M, Reyna S, Wang L, Yi Z, Carroll C, Dong LQ, Langlais P, Weintraub ST, Mandarino LJ.

Endocrinology. 2005 Oct;146(10):4410-6. Epub 2005 Jul 14.

PMID:
16020478
11.
12.
13.

Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation.

Hançer NJ, Qiu W, Cherella C, Li Y, Copps KD, White MF.

J Biol Chem. 2014 May 2;289(18):12467-84. doi: 10.1074/jbc.M114.554162. Epub 2014 Mar 20.

16.

Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells.

Waraich RS, Weigert C, Kalbacher H, Hennige AM, Lutz SZ, Häring HU, Schleicher ED, Voelter W, Lehmann R.

J Biol Chem. 2008 Apr 25;283(17):11226-33. doi: 10.1074/jbc.M708588200. Epub 2008 Feb 19.

17.

IRS-1 serine phosphorylation and insulin resistance in skeletal muscle from pancreas transplant recipients.

Bouzakri K, Karlsson HK, Vestergaard H, Madsbad S, Christiansen E, Zierath JR.

Diabetes. 2006 Mar;55(3):785-91.

18.

Caffeine modulates phosphorylation of insulin receptor substrate-1 and impairs insulin signal transduction in rat skeletal muscle.

Egawa T, Tsuda S, Ma X, Hamada T, Hayashi T.

J Appl Physiol (1985). 2011 Dec;111(6):1629-36. doi: 10.1152/japplphysiol.00249.2011. Epub 2011 Sep 22.

20.

Phosphorylation of Irs1 at SER-522 inhibits insulin signaling.

Giraud J, Haas M, Feener EP, Copps KD, Dong X, Dunn SL, White MF.

Mol Endocrinol. 2007 Sep;21(9):2294-302. Epub 2007 Jun 19.

PMID:
17579213

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