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Items: 18


HER4 D-box sequences regulate mitotic progression and degradation of the nuclear HER4 cleavage product s80HER4.

Strunk KE, Husted C, Miraglia LC, Sandahl M, Rearick WA, Hunter DM, Earp HS 3rd, Muraoka-Cook RS.

Cancer Res. 2007 Jul 15;67(14):6582-90.


The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation.

Feng SM, Muraoka-Cook RS, Hunter D, Sandahl MA, Caskey LS, Miyazawa K, Atfi A, Earp HS 3rd.

Mol Cell Biol. 2009 Feb;29(3):892-906. doi: 10.1128/MCB.00595-08. Epub 2008 Dec 1.


The intracellular domain of ErbB4 induces differentiation of mammary epithelial cells.

Muraoka-Cook RS, Sandahl M, Husted C, Hunter D, Miraglia L, Feng SM, Elenius K, Earp HS 3rd.

Mol Biol Cell. 2006 Sep;17(9):4118-29. Epub 2006 Jul 12.


The HER4 cytoplasmic domain, but not its C terminus, inhibits mammary cell proliferation.

Feng SM, Sartor CI, Hunter D, Zhou H, Yang X, Caskey LS, Dy R, Muraoka-Cook RS, Earp HS 3rd.

Mol Endocrinol. 2007 Aug;21(8):1861-76. Epub 2007 May 15.


The ErbB-4 s80 intracellular domain is a constitutively active tyrosine kinase.

Linggi B, Cheng QC, Rao AR, Carpenter G.

Oncogene. 2006 Jan 5;25(1):160-3.


Heregulin-dependent delay in mitotic progression requires HER4 and BRCA1.

Muraoka-Cook RS, Caskey LS, Sandahl MA, Hunter DM, Husted C, Strunk KE, Sartor CI, Rearick WA Jr, McCall W, Sgagias MK, Cowan KH, Earp HS 3rd.

Mol Cell Biol. 2006 Sep;26(17):6412-24.


ErbB4 splice variants Cyt1 and Cyt2 differ by 16 amino acids and exert opposing effects on the mammary epithelium in vivo.

Muraoka-Cook RS, Sandahl MA, Strunk KE, Miraglia LC, Husted C, Hunter DM, Elenius K, Chodosh LA, Earp HS 3rd.

Mol Cell Biol. 2009 Sep;29(18):4935-48. doi: 10.1128/MCB.01705-08. Epub 2009 Jul 13.


ErbB-4 s80 intracellular domain abrogates ETO2-dependent transcriptional repression.

Linggi B, Carpenter G.

J Biol Chem. 2006 Sep 1;281(35):25373-80. Epub 2006 Jun 30.


Degradation of human RAP80 is cell cycle regulated by Cdc20 and Cdh1 ubiquitin ligases.

Cho HJ, Lee EH, Han SH, Chung HJ, Jeong JH, Kwon J, Kim H.

Mol Cancer Res. 2012 May;10(5):615-25. doi: 10.1158/1541-7786.MCR-11-0481. Epub 2012 Mar 16.


Skp2 regulates G2/M progression in a p53-dependent manner.

Hu R, Aplin AE.

Mol Biol Cell. 2008 Nov;19(11):4602-10. doi: 10.1091/mbc.E07-11-1137. Epub 2008 Aug 20.


The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition.

Kang D, Chen J, Wong J, Fang G.

J Cell Biol. 2002 Jan 21;156(2):249-59. Epub 2002 Jan 21.


Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest.

Harley ME, Allan LA, Sanderson HS, Clarke PR.

EMBO J. 2010 Jul 21;29(14):2407-20. doi: 10.1038/emboj.2010.112. Epub 2010 Jun 4.


APC/C(Cdh1)-dependent degradation of Cdc20 requires a phosphorylation on CRY-box by Polo-like kinase-1 during somatic cell cycle.

Hyun SY, Sarantuya B, Lee HJ, Jang YJ.

Biochem Biophys Res Commun. 2013 Jun 21;436(1):12-8. doi: 10.1016/j.bbrc.2013.04.073. Epub 2013 May 3.


Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN.

Stroschein SL, Bonni S, Wrana JL, Luo K.

Genes Dev. 2001 Nov 1;15(21):2822-36.


Her4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells.

Sartor CI, Zhou H, Kozlowska E, Guttridge K, Kawata E, Caskey L, Harrelson J, Hynes N, Ethier S, Calvo B, Earp HS 3rd.

Mol Cell Biol. 2001 Jul;21(13):4265-75.


The ERK-RSK1 activation by growth factors at G2 phase delays cell cycle progression and reduces mitotic aberrations.

Nam HJ, Kim S, Lee MW, Lee BS, Hara T, Saya H, Cho H, Lee JH.

Cell Signal. 2008 Jul;20(7):1349-58. doi: 10.1016/j.cellsig.2008.03.008. Epub 2008 Mar 21.


A bifunctional regulatory element in human somatic Wee1 mediates cyclin A/Cdk2 binding and Crm1-dependent nuclear export.

Li C, Andrake M, Dunbrack R, Enders GH.

Mol Cell Biol. 2010 Jan;30(1):116-30. doi: 10.1128/MCB.01876-08.


Cell cycle regulation of the human Six1 homeoprotein is mediated by APC(Cdh1).

Christensen KL, Brennan JD, Aldridge CS, Ford HL.

Oncogene. 2007 May 17;26(23):3406-14. Epub 2006 Nov 20.


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