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STAT5 is required for long-term maintenance of normal and leukemic human stem/progenitor cells.

Schepers H, van Gosliga D, Wierenga AT, Eggen BJ, Schuringa JJ, Vellenga E.

Blood. 2007 Oct 15;110(8):2880-8. Epub 2007 Jul 13.


Single-cell STAT5 signal transduction profiling in normal and leukemic stem and progenitor cell populations reveals highly distinct cytokine responses.

Han L, Wierenga AT, Rozenveld-Geugien M, van de Lande K, Vellenga E, Schuringa JJ.

PLoS One. 2009 Nov 24;4(11):e7989. doi: 10.1371/journal.pone.0007989.


Mucin1 expression is enriched in the human stem cell fraction of cord blood and is upregulated in majority of the AML cases.

Fatrai S, Schepers H, Tadema H, Vellenga E, Daenen SM, Schuringa JJ.

Exp Hematol. 2008 Oct;36(10):1254-65. doi: 10.1016/j.exphem.2008.04.015. Epub 2008 Jul 21.


Characterization of a hierarchy in human acute myeloid leukemia progenitor cells.

Sutherland HJ, Blair A, Zapf RW.

Blood. 1996 Jun 1;87(11):4754-61.


STAT5-induced self-renewal and impaired myelopoiesis of human hematopoietic stem/progenitor cells involves down-modulation of C/EBPalpha.

Wierenga AT, Schepers H, Moore MA, Vellenga E, Schuringa JJ.

Blood. 2006 Jun 1;107(11):4326-33. Epub 2006 Feb 2.


Constitutive activation of Flt3 and STAT5A enhances self-renewal and alters differentiation of hematopoietic stem cells.

Moore MA, Dorn DC, Schuringa JJ, Chung KY, Morrone G.

Exp Hematol. 2007 Apr;35(4 Suppl 1):105-16.


Aberrant overexpression of the Wilms tumor gene (WT1) in human leukemia.

Inoue K, Ogawa H, Sonoda Y, Kimura T, Sakabe H, Oka Y, Miyake S, Tamaki H, Oji Y, Yamagami T, Tatekawa T, Soma T, Kishimoto T, Sugiyama H.

Blood. 1997 Feb 15;89(4):1405-12.


Chronic myelogenous leukemia primitive hematopoietic progenitors demonstrate increased sensitivity to growth factor-induced proliferation and maturation.

Bhatia R, Munthe HA, Williams AD, Zhang F, Forman SJ, Slovak ML.

Exp Hematol. 2000 Dec;28(12):1401-12.


[Growth properties of hematopoietic stem/progenitor cells in the second or third trimester and term fetal cord blood].

Ma Y, Zou P, Xiao J, Huang S.

Zhonghua Yi Xue Za Zhi. 2002 Mar;82(5):330-3. Chinese.


Impairment of granulo-monocytic development of human common myeloid progenitors but not of granulo-monocytic progenitors by decreasing stem cell leukemia/T-cell acute leukemia 1 expression.

Brunet de la Grange P, Zink E, Armstrong F, Rouyez MC, Pflumio F.

Stem Cells. 2008 Jun;26(6):1658-62. doi: 10.1634/stemcells.2007-0952. Epub 2008 Apr 24.


Interleukin 6 receptor expression by human cord blood- or peripheral blood-derived primitive haematopoietic progenitors implies acquisition of different functional properties.

Minamiguchi H, Yahata N, Kimura T, Fujiki H, Harada S, Wang J, Okuda K, Kaneko H, Hodohara K, Banba T, Yasukawa K, Ohyashiki JH, Ohyashiki K, Abe T, Sonoda Y.

Br J Haematol. 2000 Aug;110(2):327-38.


Reintroduction of C/EBPalpha in leukemic CD34+ stem/progenitor cells impairs self-renewal and partially restores myelopoiesis.

Schepers H, Wierenga AT, van Gosliga D, Eggen BJ, Vellenga E, Schuringa JJ.

Blood. 2007 Aug 15;110(4):1317-25. Epub 2007 May 2. Erratum in: Blood. 2007 Oct 15;110(8):2818.


Pegylated granulocyte colony-stimulating factor mobilizes CD34+ cells with different stem and progenitor subsets and distinct functional properties in comparison with unconjugated granulocyte colony-stimulating factor.

Bruns I, Steidl U, Fischer JC, Czibere A, Kobbe G, Raschke S, Singh R, Fenk R, Rosskopf M, Pechtel S, von Haeseler A, Wernet P, Tenen DG, Haas R, Kronenwett R.

Haematologica. 2008 Mar;93(3):347-55. doi: 10.3324/haematol.12081. Epub 2008 Feb 11.


Presence of primitive lymphoid progenitors with NK or B potential in ex vivo expanded bone marrow cell cultures.

Giarratana MC, Vergé V, Schmitt C, Bertho JM, Kobari L, Barret C, Douay L.

Exp Hematol. 2000 Jan;28(1):46-54.


Downregulation of signal transducer and activator of transcription 5 (STAT5) in CD34+ cells promotes megakaryocytic development, whereas activation of STAT5 drives erythropoiesis.

Olthof SG, Fatrai S, Drayer AL, Tyl MR, Vellenga E, Schuringa JJ.

Stem Cells. 2008 Jul;26(7):1732-42. doi: 10.1634/stemcells.2007-0899. Epub 2008 Apr 24.


Identification of HIF2alpha as an important STAT5 target gene in human hematopoietic stem cells.

Fatrai S, Wierenga AT, Daenen SM, Vellenga E, Schuringa JJ.

Blood. 2011 Mar 24;117(12):3320-30. doi: 10.1182/blood-2010-08-303669. Epub 2011 Jan 24.


Down-regulation of GATA1 uncouples STAT5-induced erythroid differentiation from stem/progenitor cell proliferation.

Wierenga AT, Vellenga E, Schuringa JJ.

Blood. 2010 Jun 3;115(22):4367-76. doi: 10.1182/blood-2009-10-250894. Epub 2010 Mar 25.


The role of STAT5 proteins in the regulation of normal hematopoiesis in a cord blood model.

Baśkiewicz-Masiuk M, Masiuk M, Czajka R, Machaliński B.

Cell Mol Biol Lett. 2003;8(2):317-31.


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