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Items: 1 to 20 of 41

1.

PKA-induced resistance to tamoxifen is associated with an altered orientation of ERalpha towards co-activator SRC-1.

Zwart W, Griekspoor A, Berno V, Lakeman K, Jalink K, Mancini M, Neefjes J, Michalides R.

EMBO J. 2007 Aug 8;26(15):3534-44. Epub 2007 Jul 12.

2.

Phosphorylation of estrogen receptor alpha, serine residue 305 enhances activity.

Tharakan R, Lepont P, Singleton D, Kumar R, Khan S.

Mol Cell Endocrinol. 2008 Nov 25;295(1-2):70-8. doi: 10.1016/j.mce.2008.07.018. Epub 2008 Aug 6.

PMID:
18755239
3.

Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer.

Michalides R, Griekspoor A, Balkenende A, Verwoerd D, Janssen L, Jalink K, Floore A, Velds A, van't Veer L, Neefjes J.

Cancer Cell. 2004 Jun;5(6):597-605.

4.

PKA phosphorylation redirects ERα to promoters of a unique gene set to induce tamoxifen resistance.

de Leeuw R, Flach K, Bentin Toaldo C, Alexi X, Canisius S, Neefjes J, Michalides R, Zwart W.

Oncogene. 2013 Jul 25;32(30):3543-51. doi: 10.1038/onc.2012.361. Epub 2012 Aug 20.

PMID:
22907427
5.

PKA-induced phosphorylation of ERα at serine 305 and high PAK1 levels is associated with sensitivity to tamoxifen in ER-positive breast cancer.

Kok M, Zwart W, Holm C, Fles R, Hauptmann M, Van't Veer LJ, Wessels LF, Neefjes J, Stål O, Linn SC, Landberg G, Michalides R.

Breast Cancer Res Treat. 2011 Jan;125(1):1-12. doi: 10.1007/s10549-010-0798-y. Epub 2010 Mar 9.

PMID:
20213082
6.
7.

Protein Kinase A-induced tamoxifen resistance is mediated by anchoring protein AKAP13.

Bentin Toaldo C, Alexi X, Beelen K, Kok M, Hauptmann M, Jansen M, Berns E, Neefjes J, Linn S, Michalides R, Zwart W.

BMC Cancer. 2015 Aug 14;15:588. doi: 10.1186/s12885-015-1591-4.

9.

Role of AIB1 for tamoxifen resistance in estrogen receptor-positive breast cancer cells.

Su Q, Hu S, Gao H, Ma R, Yang Q, Pan Z, Wang T, Li F.

Oncology. 2008;75(3-4):159-68. doi: 10.1159/000159267. Epub 2008 Oct 1.

PMID:
18827493
10.

The hinge region of the human estrogen receptor determines functional synergy between AF-1 and AF-2 in the quantitative response to estradiol and tamoxifen.

Zwart W, de Leeuw R, Rondaij M, Neefjes J, Mancini MA, Michalides R.

J Cell Sci. 2010 Apr 15;123(Pt 8):1253-61. doi: 10.1242/jcs.061135. Epub 2010 Mar 23.

11.

MUC1 oncoprotein stabilizes and activates estrogen receptor alpha.

Wei X, Xu H, Kufe D.

Mol Cell. 2006 Jan 20;21(2):295-305.

12.

P21-activated kinase 1 regulation of estrogen receptor-alpha activation involves serine 305 activation linked with serine 118 phosphorylation.

Rayala SK, Talukder AH, Balasenthil S, Tharakan R, Barnes CJ, Wang RA, Aldaz CM, Khan S, Kumar R.

Cancer Res. 2006 Feb 1;66(3):1694-701.

13.

Coactivator-mediated estrogen response in human squamous cell carcinoma lines.

Ku TK, Crowe DL.

J Endocrinol. 2007 Apr;193(1):147-55.

PMID:
17400812
15.

CARM1 mediates the ligand-independent and tamoxifen-resistant activation of the estrogen receptor alpha by cAMP.

Carascossa S, Dudek P, Cenni B, Briand PA, Picard D.

Genes Dev. 2010 Apr 1;24(7):708-19. doi: 10.1101/gad.568410.

16.

CK1delta modulates the transcriptional activity of ERalpha via AIB1 in an estrogen-dependent manner and regulates ERalpha-AIB1 interactions.

Giamas G, Castellano L, Feng Q, Knippschild U, Jacob J, Thomas RS, Coombes RC, Smith CL, Jiao LR, Stebbing J.

Nucleic Acids Res. 2009 May;37(9):3110-23. doi: 10.1093/nar/gkp136. Epub 2009 Apr 1.

17.

Phosphorylation of estrogen receptor alpha blocks its acetylation and regulates estrogen sensitivity.

Cui Y, Zhang M, Pestell R, Curran EM, Welshons WV, Fuqua SA.

Cancer Res. 2004 Dec 15;64(24):9199-208.

18.

Phosphorylation of ERalpha at serine 118 in primary breast cancer and in tamoxifen-resistant tumours is indicative of a complex role for ERalpha phosphorylation in breast cancer progression.

Sarwar N, Kim JS, Jiang J, Peston D, Sinnett HD, Madden P, Gee JM, Nicholson RI, Lykkesfeldt AE, Shousha S, Coombes RC, Ali S.

Endocr Relat Cancer. 2006 Sep;13(3):851-61.

PMID:
16954434
19.

Reactive oxygen species induce phosphorylation of serine 118 and 167 on estrogen receptor alpha.

Weitsman GE, Weebadda W, Ung K, Murphy LC.

Breast Cancer Res Treat. 2009 Nov;118(2):269-79. doi: 10.1007/s10549-008-0221-0. Epub 2008 Oct 21.

PMID:
18941890
20.

Positive feedback activation of estrogen receptors by the CXCL12-CXCR4 pathway.

Sauvé K, Lepage J, Sanchez M, Heveker N, Tremblay A.

Cancer Res. 2009 Jul 15;69(14):5793-800. doi: 10.1158/0008-5472.CAN-08-4924. Epub 2009 Jul 7.

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