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Items: 1 to 20 of 193


Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance.

Babitt JL, Huang FW, Xia Y, Sidis Y, Andrews NC, Lin HY.

J Clin Invest. 2007 Jul;117(7):1933-9.


Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression.

Babitt JL, Huang FW, Wrighting DM, Xia Y, Sidis Y, Samad TA, Campagna JA, Chung RT, Schneyer AL, Woolf CJ, Andrews NC, Lin HY.

Nat Genet. 2006 May;38(5):531-9. Epub 2006 Apr 9.


Hepcidin regulation: ironing out the details.

De Domenico I, Ward DM, Kaplan J.

J Clin Invest. 2007 Jul;117(7):1755-8.


Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin.

Xia Y, Babitt JL, Sidis Y, Chung RT, Lin HY.

Blood. 2008 May 15;111(10):5195-204. doi: 10.1182/blood-2007-09-111567. Epub 2008 Mar 7.


Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis.

Lee DH, Zhou LJ, Zhou Z, Xie JX, Jung JU, Liu Y, Xi CX, Mei L, Xiong WC.

Blood. 2010 Apr 15;115(15):3136-45. doi: 10.1182/blood-2009-11-251199. Epub 2010 Jan 11. Erratum in: Blood. 2010 Jul 8;116(1):151. Lee, Dai-Hoon [corrected to Lee, Dae-Hoon]; Zhou, Li-Juau [corrected to Zhou, Li-Juan]; Xie, Jiau-Xiu [corrected to Xie, Jian-Xin].


Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis.

Finberg KE, Whittlesey RL, Fleming MD, Andrews NC.

Blood. 2010 May 6;115(18):3817-26. doi: 10.1182/blood-2009-05-224808. Epub 2010 Mar 3.


Neogenin Facilitates the Induction of Hepcidin Expression by Hemojuvelin in the Liver.

Zhao N, Maxson JE, Zhang RH, Wahedi M, Enns CA, Zhang AS.

J Biol Chem. 2016 Jun 3;291(23):12322-35. doi: 10.1074/jbc.M116.721191. Epub 2016 Apr 12.


BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism.

Andriopoulos B Jr, Corradini E, Xia Y, Faasse SA, Chen S, Grgurevic L, Knutson MD, Pietrangelo A, Vukicevic S, Lin HY, Babitt JL.

Nat Genet. 2009 Apr;41(4):482-7. doi: 10.1038/ng.335. Epub 2009 Mar 1.


Evidence that inhibition of hemojuvelin shedding in response to iron is mediated through neogenin.

Zhang AS, Anderson SA, Meyers KR, Hernandez C, Eisenstein RS, Enns CA.

J Biol Chem. 2007 Apr 27;282(17):12547-56. Epub 2007 Mar 1.


Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis.

Silvestri L, Pagani A, Camaschella C.

Blood. 2008 Jan 15;111(2):924-31. Epub 2007 Oct 15.


Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis.

Lakhal S, Schödel J, Townsend AR, Pugh CW, Ratcliffe PJ, Mole DR.

J Biol Chem. 2011 Feb 11;286(6):4090-7. doi: 10.1074/jbc.M110.173096. Epub 2010 Oct 21.


Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD.

Casanovas G, Mleczko-Sanecka K, Altamura S, Hentze MW, Muckenthaler MU.

J Mol Med (Berl). 2009 May;87(5):471-80. doi: 10.1007/s00109-009-0447-2. Epub 2009 Feb 20.


Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice.

Steinbicker AU, Bartnikas TB, Lohmeyer LK, Leyton P, Mayeur C, Kao SM, Pappas AE, Peterson RT, Bloch DB, Yu PB, Fleming MD, Bloch KD.

Blood. 2011 Oct 13;118(15):4224-30. doi: 10.1182/blood-2011-03-339952. Epub 2011 Aug 12.


Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6.

Truksa J, Peng H, Lee P, Beutler E.

Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10289-93. Epub 2006 Jun 26.


A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells.

Verga Falzacappa MV, Casanovas G, Hentze MW, Muckenthaler MU.

J Mol Med (Berl). 2008 May;86(5):531-40. doi: 10.1007/s00109-008-0313-7. Epub 2008 Apr 18.


Modulation of hepcidin to treat iron deregulation: potential clinical applications.

Blanchette NL, Manz DH, Torti FM, Torti SV.

Expert Rev Hematol. 2016;9(2):169-86. doi: 10.1586/17474086.2016.1124757. Epub 2015 Dec 15. Review.


Hfe and Hjv exhibit overlapping functions for iron signaling to hepcidin.

Kent P, Wilkinson N, Constante M, Fillebeen C, Gkouvatsos K, Wagner J, Buffler M, Becker C, Schümann K, Santos MM, Pantopoulos K.

J Mol Med (Berl). 2015 May;93(5):489-98. doi: 10.1007/s00109-015-1253-7. Epub 2015 Jan 23.


Iron regulation by hepcidin.

Zhao N, Zhang AS, Enns CA.

J Clin Invest. 2013 Jun;123(6):2337-43. doi: 10.1172/JCI67225. Epub 2013 Jun 3.


The role of hepatocyte hemojuvelin in the regulation of bone morphogenic protein-6 and hepcidin expression in vivo.

Zhang AS, Gao J, Koeberl DD, Enns CA.

J Biol Chem. 2010 May 28;285(22):16416-23. doi: 10.1074/jbc.M110.109488. Epub 2010 Apr 2.


SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression.

Mleczko-Sanecka K, Casanovas G, Ragab A, Breitkopf K, Müller A, Boutros M, Dooley S, Hentze MW, Muckenthaler MU.

Blood. 2010 Apr 1;115(13):2657-65. doi: 10.1182/blood-2009-09-238105. Epub 2009 Dec 29.

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