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High tidal volume mechanical ventilation with hyperoxia alters alveolar type II cell adhesion.

Desai LP, Sinclair SE, Chapman KE, Hassid A, Waters CM.

Am J Physiol Lung Cell Mol Physiol. 2007 Sep;293(3):L769-78. Epub 2007 Jun 29.


Hyperoxia increases the elastic modulus of alveolar epithelial cells through Rho kinase.

Wilhelm KR, Roan E, Ghosh MC, Parthasarathi K, Waters CM.

FEBS J. 2014 Feb;281(3):957-69. doi: 10.1111/febs.12661. Epub 2013 Dec 24.


Protein tyrosine phosphatases mediate cell readhesion in alveolar epithelial cells mechanically separated from in vitro matrix.

Oliver BL, Garat C, Pytela R, Matthay MA.

Am J Respir Cell Mol Biol. 1997 May;16(5):613-20.


Focal adhesion kinase-related nonkinase inhibits vascular smooth muscle cell invasion by focal adhesion targeting, tyrosine 168 phosphorylation, and competition for p130(Cas) binding.

Koshman YE, Chu M, Engman SJ, Kim T, Iyengar R, Robia SL, Samarel AM.

Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2432-40. doi: 10.1161/ATVBAHA.111.235549.


Preexposure to hyperoxia causes increased lung injury and epithelial apoptosis in mice ventilated with high tidal volumes.

Makena PS, Luellen CL, Balazs L, Ghosh MC, Parthasarathi K, Waters CM, Sinclair SE.

Am J Physiol Lung Cell Mol Physiol. 2010 Nov;299(5):L711-9. doi: 10.1152/ajplung.00072.2010. Epub 2010 Sep 10.


Pulmonary effects of keratinocyte growth factor in newborn rats exposed to hyperoxia.

Franco-Montoya ML, Bourbon JR, Durrmeyer X, Lorotte S, Jarreau PH, Delacourt C.

Am J Physiol Lung Cell Mol Physiol. 2009 Nov;297(5):L965-76. doi: 10.1152/ajplung.00136.2009. Epub 2009 Aug 21.


Hyperoxia alters the mechanical properties of alveolar epithelial cells.

Roan E, Wilhelm K, Bada A, Makena PS, Gorantla VK, Sinclair SE, Waters CM.

Am J Physiol Lung Cell Mol Physiol. 2012 Jun 15;302(12):L1235-41. doi: 10.1152/ajplung.00223.2011. Epub 2012 Mar 30.


Intratracheal instillation of keratinocyte growth factor decreases hyperoxia-induced mortality in rats.

Panos RJ, Bak PM, Simonet WS, Rubin JS, Smith LJ.

J Clin Invest. 1995 Oct;96(4):2026-33.


Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability.

Holinstat M, Knezevic N, Broman M, Samarel AM, Malik AB, Mehta D.

J Biol Chem. 2006 Jan 27;281(4):2296-305. Epub 2005 Nov 24.


Connective tissue growth factor [CTGF]/CCN2 stimulates mesangial cell migration through integrated dissolution of focal adhesion complexes and activation of cell polarization.

Crean JK, Furlong F, Finlay D, Mitchell D, Murphy M, Conway B, Brady HR, Godson C, Martin F.

FASEB J. 2004 Oct;18(13):1541-3. Epub 2004 Aug 19.


Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly.

Orr AW, Pallero MA, Xiong WC, Murphy-Ullrich JE.

J Biol Chem. 2004 Nov 19;279(47):48983-92. Epub 2004 Sep 13.


Hydrogen peroxide activates focal adhesion kinase and c-Src by a phosphatidylinositol 3 kinase-dependent mechanism and promotes cell migration in Caco-2 cell monolayers.

Basuroy S, Dunagan M, Sheth P, Seth A, Rao RK.

Am J Physiol Gastrointest Liver Physiol. 2010 Jul;299(1):G186-95. doi: 10.1152/ajpgi.00368.2009. Epub 2010 Apr 8.

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