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Items: 1 to 20 of 148

1.

Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor.

Rosenkilde MM, Gerlach LO, Hatse S, Skerlj RT, Schols D, Bridger GJ, Schwartz TW.

J Biol Chem. 2007 Sep 14;282(37):27354-65.

2.

Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor.

Rosenkilde MM, Gerlach LO, Jakobsen JS, Skerlj RT, Bridger GJ, Schwartz TW.

J Biol Chem. 2004 Jan 23;279(4):3033-41.

3.

Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor.

Gerlach LO, Skerlj RT, Bridger GJ, Schwartz TW.

J Biol Chem. 2001 Apr 27;276(17):14153-60.

4.

AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor.

Hatse S, Princen K, De Clercq E, Rosenkilde MM, Schwartz TW, Hernandez-Abad PE, Skerlj RT, Bridger GJ, Schols D.

Biochem Pharmacol. 2005 Sep 1;70(5):752-61.

PMID:
16011832
5.

Metal ion enhanced binding of AMD3100 to Asp262 in the CXCR4 receptor.

Gerlach LO, Jakobsen JS, Jensen KP, Rosenkilde MR, Skerlj RT, Ryde U, Bridger GJ, Schwartz TW.

Biochemistry. 2003 Jan 28;42(3):710-7.

PMID:
12534283
6.
7.

Pharmacology of AMD3465: a small molecule antagonist of the chemokine receptor CXCR4.

Bodart V, Anastassov V, Darkes MC, Idzan SR, Labrecque J, Lau G, Mosi RM, Neff KS, Nelson KL, Ruzek MC, Patel K, Santucci Z, Scarborough R, Wong RS, Bridger GJ, Macfarland RT, Fricker SP.

Biochem Pharmacol. 2009 Oct 15;78(8):993-1000. doi: 10.1016/j.bcp.2009.06.010.

PMID:
19540208
8.

Importance of receptor flexibility in binding of cyclam compounds to the chemokine receptor CXCR4.

Lam AR, Bhattacharya S, Patel K, Hall SE, Mao A, Vaidehi N.

J Chem Inf Model. 2011 Jan 24;51(1):139-47. doi: 10.1021/ci1003027.

PMID:
21158459
9.

Discovery of novel non-cyclam polynitrogenated CXCR4 coreceptor inhibitors.

Pettersson S, Pérez-Nueno VI, Ros-Blanco L, Puig de La Bellacasa R, Rabal MO, Batllori X, Clotet B, Clotet-Codina I, Armand-Ugón M, Esté J, Borrell JI, Teixidó J.

ChemMedChem. 2008 Oct;3(10):1549-57. doi: 10.1002/cmdc.200800145.

PMID:
18671217
10.

Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-azamacrocycles that inhibit HIV-1 and HIV-2 replication by antagonism of the chemokine receptor CXCR4.

Bridger GJ, Skerlj RT, Padmanabhan S, Martellucci SA, Henson GW, Struyf S, Witvrouw M, Schols D, De Clercq E.

J Med Chem. 1999 Sep 23;42(19):3971-81.

PMID:
10508445
11.

Activity of different bicyclam derivatives against human immunodeficiency virus depends on their interaction with the CXCR4 chemokine receptor.

Esté JA, Cabrera C, De Clercq E, Struyf S, Van Damme J, Bridger G, Skerlj RT, Abrams MJ, Henson G, Gutierrez A, Clotet B, Schols D.

Mol Pharmacol. 1999 Jan;55(1):67-73.

12.

Potential clinical applications of the CXCR4 antagonist bicyclam AMD3100.

De Clercq E.

Mini Rev Med Chem. 2005 Sep;5(9):805-24. Review.

PMID:
16178723
13.
14.

Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry.

Hatse S, Princen K, Vermeire K, Gerlach LO, Rosenkilde MM, Schwartz TW, Bridger G, De Clercq E, Schols D.

FEBS Lett. 2003 Jul 10;546(2-3):300-6.

15.

Synthesis and structure-activity relationships of azamacrocyclic C-X-C chemokine receptor 4 antagonists: analogues containing a single azamacrocyclic ring are potent inhibitors of T-cell tropic (X4) HIV-1 replication.

Bridger GJ, Skerlj RT, Hernandez-Abad PE, Bogucki DE, Wang Z, Zhou Y, Nan S, Boehringer EM, Wilson T, Crawford J, Metz M, Hatse S, Princen K, De Clercq E, Schols D.

J Med Chem. 2010 Feb 11;53(3):1250-60. doi: 10.1021/jm901530b.

PMID:
20043638
16.

The bicyclam AMD3100 story.

De Clercq E.

Nat Rev Drug Discov. 2003 Jul;2(7):581-7. Review.

PMID:
12815382
17.

T134, a small-molecule CXCR4 inhibitor, has no cross-drug resistance with AMD3100, a CXCR4 antagonist with a different structure.

Arakaki R, Tamamura H, Premanathan M, Kanbara K, Ramanan S, Mochizuki K, Baba M, Fujii N, Nakashima H.

J Virol. 1999 Feb;73(2):1719-23.

18.

Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8.

Jensen PC, Nygaard R, Thiele S, Elder A, Zhu G, Kolbeck R, Ghosh S, Schwartz TW, Rosenkilde MM.

Mol Pharmacol. 2007 Aug;72(2):327-40. Erratum in: Mol Pharmacol. 2008 Aug;74(2):539. Mol Pharmacol. 2007 Oct;72(4):1095.

19.

Novel monocyclam derivatives as HIV entry inhibitors: Design, synthesis, anti-HIV evaluation, and their interaction with the CXCR4 co-receptor.

Pettersson S, Pérez-Nueno VI, Mena MP, Clotet B, Esté JA, Borrell JI, Teixidó J.

ChemMedChem. 2010 Aug 2;5(8):1272-81. doi: 10.1002/cmdc.201000124.

PMID:
20533501
20.
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