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Items: 1 to 20 of 140


NMR structure of a KlbA intein precursor from Methanococcus jannaschii.

Johnson MA, Southworth MW, Herrmann T, Brace L, Perler FB, Wüthrich K.

Protein Sci. 2007 Jul;16(7):1316-28.


Branched intermediate formation is the slowest step in the protein splicing reaction of the Ala1 KlbA intein from Methanococcus jannaschii.

Saleh L, Southworth MW, Considine N, O'Neill C, Benner J, Bollinger JM Jr, Perler FB.

Biochemistry. 2011 Dec 13;50(49):10576-89. doi: 10.1021/bi200810j. Epub 2011 Nov 16.


NMR and crystal structures of the Pyrococcus horikoshii RadA intein guide a strategy for engineering a highly efficient and promiscuous intein.

Oeemig JS, Zhou D, Kajander T, Wlodawer A, Iwaï H.

J Mol Biol. 2012 Aug 3;421(1):85-99. doi: 10.1016/j.jmb.2012.04.029. Epub 2012 May 2.


The Thermococcus kodakaraensis Tko CDC21-1 intein activates its N-terminal splice junction in the absence of a conserved histidine by a compensatory mechanism.

Tori K, Cheriyan M, Pedamallu CS, Contreras MA, Perler FB.

Biochemistry. 2012 Mar 27;51(12):2496-505. doi: 10.1021/bi201840k. Epub 2012 Mar 13.


Structural and dynamical features of inteins and implications on protein splicing.

Eryilmaz E, Shah NH, Muir TW, Cowburn D.

J Biol Chem. 2014 May 23;289(21):14506-11. doi: 10.1074/jbc.R113.540302. Epub 2014 Apr 2. Review.


Post-translational environmental switch of RadA activity by extein-intein interactions in protein splicing.

Topilina NI, Novikova O, Stanger M, Banavali NK, Belfort M.

Nucleic Acids Res. 2015 Jul 27;43(13):6631-48. doi: 10.1093/nar/gkv612. Epub 2015 Jun 22.


Faster protein splicing with the Nostoc punctiforme DnaE intein using non-native extein residues.

Cheriyan M, Pedamallu CS, Tori K, Perler F.

J Biol Chem. 2013 Mar 1;288(9):6202-11. doi: 10.1074/jbc.M112.433094. Epub 2013 Jan 10.


Inteins, valuable genetic elements in molecular biology and biotechnology.

Elleuche S, Pöggeler S.

Appl Microbiol Biotechnol. 2010 Jun;87(2):479-89. doi: 10.1007/s00253-010-2628-x. Epub 2010 May 7. Review.


Electronic structure of neighboring extein residue modulates intein C-terminal cleavage activity.

Shemella PT, Topilina NI, Soga I, Pereira B, Belfort G, Belfort M, Nayak SK.

Biophys J. 2011 May 4;100(9):2217-25. doi: 10.1016/j.bpj.2011.02.037.


Structural and mutational studies of a hyperthermophilic intein from DNA polymerase II of Pyrococcus abyssi.

Du Z, Liu J, Albracht CD, Hsu A, Chen W, Marieni MD, Colelli KM, Williams JE, Reitter JN, Mills KV, Wang C.

J Biol Chem. 2011 Nov 4;286(44):38638-48. doi: 10.1074/jbc.M111.290569. Epub 2011 Sep 13.


Modulation of intein activity by its neighboring extein substrates.

Amitai G, Callahan BP, Stanger MJ, Belfort G, Belfort M.

Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11005-10. doi: 10.1073/pnas.0904366106. Epub 2009 Jun 17.


Crystal structure of GyrA intein from Mycobacterium xenopi reveals structural basis of protein splicing.

Klabunde T, Sharma S, Telenti A, Jacobs WR Jr, Sacchettini JC.

Nat Struct Biol. 1998 Jan;5(1):31-6.


Traceless splicing enabled by substrate-induced activation of the Nostoc punctiforme Npu DnaE intein after mutation of a catalytic cysteine to serine.

Cheriyan M, Chan SH, Perler F.

J Mol Biol. 2014 Dec 12;426(24):4018-29. doi: 10.1016/j.jmb.2014.10.025. Epub 2014 Nov 6.


Protein splicing: how inteins escape from precursor proteins.

Mills KV, Johnson MA, Perler FB.

J Biol Chem. 2014 May 23;289(21):14498-505. doi: 10.1074/jbc.R113.540310. Epub 2014 Apr 2. Review.


Protein splicing in the absence of an intein penultimate histidine.

Chen L, Benner J, Perler FB.

J Biol Chem. 2000 Jul 7;275(27):20431-5.


NMR assignment of a KlbA intein precursor from Methanococcus jannaschii.

Johnson MA, Southworth MW, Perler FB, Wüthrich K.

Biomol NMR Assign. 2007 Jul;1(1):19-21. doi: 10.1007/s12104-007-9009-0. Epub 2007 May 5.


Splicing of the mycobacteriophage Bethlehem DnaB intein: identification of a new mechanistic class of inteins that contain an obligate block F nucleophile.

Tori K, Dassa B, Johnson MA, Southworth MW, Brace LE, Ishino Y, Pietrokovski S, Perler FB.

J Biol Chem. 2010 Jan 22;285(4):2515-26. doi: 10.1074/jbc.M109.069567. Epub 2009 Nov 22.


Design of an intein that can be inhibited with a small molecule ligand.

Brenzel S, Mootz HD.

J Am Chem Soc. 2005 Mar 30;127(12):4176-7.

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