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Items: 1 to 20 of 97

1.

Unacylated ghrelin acts as a potent insulin secretagogue in glucose-stimulated conditions.

Gauna C, Kiewiet RM, Janssen JA, van de Zande B, Delhanty PJ, Ghigo E, Hofland LJ, Themmen AP, van der Lely AJ.

Am J Physiol Endocrinol Metab. 2007 Sep;293(3):E697-704. Epub 2007 Jun 19.

2.

Intravenous glucose administration in fasting rats has differential effects on acylated and unacylated ghrelin in the portal and systemic circulation: a comparison between portal and peripheral concentrations in anesthetized rats.

Gauna C, Uitterlinden P, Kramer P, Kiewiet RM, Janssen JA, Delhanty PJ, van Aken MO, Ghigo E, Hofland LJ, Themmen AP, van der Lely AJ.

Endocrinology. 2007 Nov;148(11):5278-87. Epub 2007 Aug 2.

PMID:
17673520
3.

Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor.

Gauna C, Delhanty PJ, van Aken MO, Janssen JA, Themmen AP, Hofland LJ, Culler M, Broglio F, Ghigo E, van der Lely AJ.

Mol Cell Endocrinol. 2006 Jun 7;251(1-2):103-11. Epub 2006 Apr 27.

PMID:
16647196
4.

Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans.

Broglio F, Gottero C, Prodam F, Gauna C, Muccioli G, Papotti M, Abribat T, Van Der Lely AJ, Ghigo E.

J Clin Endocrinol Metab. 2004 Jun;89(6):3062-5.

PMID:
15181099
5.

In vitro and in vivo effect of acylated and unacylated ghrelin on neonatal glucose homeostasis.

Ni H, De Waele K, Walia P, Chanoine JP.

Pediatr Res. 2010 Jun;67(6):609-13. doi: 10.1203/PDR.0b013e3181da463a.

PMID:
20496472
6.

Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-Kinase/Akt signaling.

Granata R, Settanni F, Biancone L, Trovato L, Nano R, Bertuzzi F, Destefanis S, Annunziata M, Martinetti M, Catapano F, Ghè C, Isgaard J, Papotti M, Ghigo E, Muccioli G.

Endocrinology. 2007 Feb;148(2):512-29. Epub 2006 Oct 26.

PMID:
17068144
7.

Acute administration of unacylated ghrelin has no effect on Basal or stimulated insulin secretion in healthy humans.

Tong J, Davis HW, Summer S, Benoit SC, Haque A, Bidlingmaier M, Tschöp MH, D'Alessio D.

Diabetes. 2014 Jul;63(7):2309-19. doi: 10.2337/db13-1598. Epub 2014 Feb 18.

8.

Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes.

Gauna C, Delhanty PJ, Hofland LJ, Janssen JA, Broglio F, Ross RJ, Ghigo E, van der Lely AJ.

J Clin Endocrinol Metab. 2005 Feb;90(2):1055-60. Epub 2004 Nov 9.

PMID:
15536157
9.

Bolus administration of obestatin does not change glucose and insulin levels neither in the systemic nor in the portal circulation of the rat.

Kiewiet RM, Gauna C, van Aken MO, van de Zande B, van der Lely AJ.

Peptides. 2008 Dec;29(12):2144-9. doi: 10.1016/j.peptides.2008.09.011. Epub 2008 Sep 26.

PMID:
18930090
10.

Effects of acute administration of acylated and unacylated ghrelin on glucose and insulin concentrations in morbidly obese subjects without overt diabetes.

Kiewiet RM, van Aken MO, van der Weerd K, Uitterlinden P, Themmen AP, Hofland LJ, de Rijke YB, Delhanty PJ, Ghigo E, Abribat T, van der Lely AJ.

Eur J Endocrinol. 2009 Oct;161(4):567-73. doi: 10.1530/EJE-09-0339. Epub 2009 Jul 23.

11.

Comparative analysis of the effects of ghrelin and unacylated ghrelin on luteinizing hormone secretion in male rats.

Martini AC, Fernández-Fernández R, Tovar S, Navarro VM, Vigo E, Vazquez MJ, Davies JS, Thompson NM, Aguilar E, Pinilla L, Wells T, Dieguez C, Tena-Sempere M.

Endocrinology. 2006 May;147(5):2374-82. Epub 2006 Feb 2.

PMID:
16455774
12.

Ghrelin and new metabolic frontiers.

van der Lely AJ.

Horm Res. 2009 Jan;71 Suppl 1:129-33. doi: 10.1159/000178055. Epub 2009 Jan 21. Review.

PMID:
19153523
13.

Unacylated ghrelin and obestatin increase islet cell mass and prevent diabetes in streptozotocin-treated newborn rats.

Granata R, Volante M, Settanni F, Gauna C, Ghé C, Annunziata M, Deidda B, Gesmundo I, Abribat T, van der Lely AJ, Muccioli G, Ghigo E, Papotti M.

J Mol Endocrinol. 2010 Jul;45(1):9-17. doi: 10.1677/JME-09-0141. Epub 2010 Apr 9.

PMID:
20382773
14.

D-Lys(3)-GHRP-6 antagonizes the effect of unacylated but not of acylated ghrelin on the growth of HECa10 murine endothelial cells.

Polowinczak-Przybylek J, Siejka A, Melen-Mucha G.

Peptides. 2012 Dec;38(2):248-54. doi: 10.1016/j.peptides.2012.09.029. Epub 2012 Oct 5.

PMID:
23044212
15.

Ghrelin and its unacylated isoform stimulate the growth of adrenocortical tumor cells via an anti-apoptotic pathway.

Delhanty PJ, van Koetsveld PM, Gauna C, van de Zande B, Vitale G, Hofland LJ, van der Lely AJ.

Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E302-9. Epub 2007 Apr 3.

16.
17.

Metabolic effects of overnight continuous infusion of unacylated ghrelin in humans.

Benso A, St-Pierre DH, Prodam F, Gramaglia E, Granata R, van der Lely AJ, Ghigo E, Broglio F.

Eur J Endocrinol. 2012 May;166(5):911-6. doi: 10.1530/EJE-11-0982. Epub 2012 Feb 29.

18.

Acylated and unacylated ghrelin during OGTT in Prader-Willi syndrome: support for normal response to food intake.

Kuppens RJ, Delhanty PJ, Huisman TM, van der Lely AJ, Hokken-Koelega AC.

Clin Endocrinol (Oxf). 2016 Sep;85(3):488-94. doi: 10.1111/cen.13036. Epub 2016 Feb 23.

PMID:
26850227
19.

Administration of acylated ghrelin reduces insulin sensitivity, whereas the combination of acylated plus unacylated ghrelin strongly improves insulin sensitivity.

Gauna C, Meyler FM, Janssen JA, Delhanty PJ, Abribat T, van Koetsveld P, Hofland LJ, Broglio F, Ghigo E, van der Lely AJ.

J Clin Endocrinol Metab. 2004 Oct;89(10):5035-42.

PMID:
15472202
20.

Obestatin levels are associated with C-peptide and antiinsulin antibodies at the onset, whereas unacylated and acylated ghrelin levels are not predictive of long-term metabolic control in children with type 1 diabetes.

Prodam F, Cadario F, Bellone S, Trovato L, Moia S, Pozzi E, Savastio S, Bona G.

J Clin Endocrinol Metab. 2014 Apr;99(4):E599-607. doi: 10.1210/jc.2013-3294. Epub 2014 Jan 17.

PMID:
24438371

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