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Matrix protein 2 vaccination and protection against influenza viruses, including subtype H5N1.

Tompkins SM, Zhao ZS, Lo CY, Misplon JA, Liu T, Ye Z, Hogan RJ, Wu Z, Benton KA, Tumpey TM, Epstein SL.

Emerg Infect Dis. 2007 Mar;13(3):426-35.


Co-administration of certain DNA vaccine combinations expressing different H5N1 influenza virus antigens can be beneficial or detrimental to immune protection.

Patel A, Gray M, Li Y, Kobasa D, Yao X, Kobinger GP.

Vaccine. 2012 Jan 11;30(3):626-36. doi: 10.1016/j.vaccine.2011.11.017. Epub 2011 Nov 23.


Heterosubtypic protective immunity against widely divergent influenza subtypes induced by fusion protein 4sM2 in BALB/c mice.

Chowdhury MY, Seo SK, Moon HJ, Talactac MR, Kim JH, Park ME, Son HY, Lee JS, Kim CJ.

Virol J. 2014 Feb 6;11:21. doi: 10.1186/1743-422X-11-21.


Comparison of vaccines for induction of heterosubtypic immunity to influenza A virus: cold-adapted vaccine versus DNA prime-adenovirus boost strategies.

Lo CY, Wu Z, Misplon JA, Price GE, Pappas C, Kong WP, Tumpey TM, Epstein SL.

Vaccine. 2008 Apr 16;26(17):2062-72. doi: 10.1016/j.vaccine.2008.02.047. Epub 2008 Mar 13.


[Immunological evaluation of vector-expressed M2 and HA genes of H5N1 influenza virus in mice].

Guo J, Yao L, Chen A, Xu Y, Liu X, Shu Y, Zhang Z.

Sheng Wu Gong Cheng Xue Bao. 2010 May;26(5):649-56. Chinese.


Heterosubtypic immunity to influenza mediated by liposome adjuvanted H5N1 recombinant protein vaccines.

Thueng-in K, Maneewatch S, Srimanote P, Songserm T, Tapchaisri P, Sookrung N, Tongtawe P, Channarong S, Chaicumpa W.

Vaccine. 2010 Sep 24;28(41):6765-77. doi: 10.1016/j.vaccine.2010.07.065. Epub 2010 Aug 3.


Complete protection against a H5N2 avian influenza virus by a DNA vaccine expressing a fusion protein of H1N1 HA and M2e.

Park KS, Seo YB, Lee JY, Im SJ, Seo SH, Song MS, Choi YK, Sung YC.

Vaccine. 2011 Jul 26;29(33):5481-7. doi: 10.1016/j.vaccine.2011.05.062. Epub 2011 Jun 12.


Vaccination focusing immunity on conserved antigens protects mice and ferrets against virulent H1N1 and H5N1 influenza A viruses.

Price GE, Soboleski MR, Lo CY, Misplon JA, Pappas C, Houser KV, Tumpey TM, Epstein SL.

Vaccine. 2009 Nov 5;27(47):6512-21. doi: 10.1016/j.vaccine.2009.08.053. Epub 2009 Sep 1.


Protection of mice and poultry from lethal H5N1 avian influenza virus through adenovirus-based immunization.

Gao W, Soloff AC, Lu X, Montecalvo A, Nguyen DC, Matsuoka Y, Robbins PD, Swayne DE, Donis RO, Katz JM, Barratt-Boyes SM, Gambotto A.

J Virol. 2006 Feb;80(4):1959-64.


Cross-protection against influenza virus infection by intranasal administration of M2-based vaccine with chitosan as an adjuvant.

Sui Z, Chen Q, Wu R, Zhang H, Zheng M, Wang H, Chen Z.

Arch Virol. 2010 Apr;155(4):535-44. doi: 10.1007/s00705-010-0621-4. Epub 2010 Feb 27.


Mucosal immunity induced by adenovirus-based H5N1 HPAI vaccine confers protection against a lethal H5N2 avian influenza virus challenge.

Park KS, Lee J, Ahn SS, Byun YH, Seong BL, Baek YH, Song MS, Choi YK, Na YJ, Hwang I, Sung YC, Lee CG.

Virology. 2009 Dec 20;395(2):182-9. doi: 10.1016/j.virol.2009.09.018.


Protection of mice against influenza A virus challenge by vaccination with baculovirus-expressed M2 protein.

Slepushkin VA, Katz JM, Black RA, Gamble WC, Rota PA, Cox NJ.

Vaccine. 1995;13(15):1399-402.


Prokaryote-expressed M2e protein improves H9N2 influenza vaccine efficacy and protection against lethal influenza A virus in mice.

Kim EH, Lee JH, Pascua PN, Song MS, Baek YH, Kwon HI, Park SJ, Lim GJ, Decano A, Chowdhury MY, Seo SK, Song MK, Kim CJ, Choi YK.

Virol J. 2013 Apr 3;10:104. doi: 10.1186/1743-422X-10-104.


In contrast to conventional inactivated influenza vaccines, 4xM2e.HSP70c fusion protein fully protected mice against lethal dose of H1, H3 and H9 influenza A isolates circulating in Iran.

Ebrahimi SM, Dabaghian M, Tebianian M, Jazi MH.

Virology. 2012 Aug 15;430(1):63-72. doi: 10.1016/j.virol.2012.04.015. Epub 2012 May 16.


An M2e-based multiple antigenic peptide vaccine protects mice from lethal challenge with divergent H5N1 influenza viruses.

Zhao G, Lin Y, Du L, Guan J, Sun S, Sui H, Kou Z, Chan CC, Guo Y, Jiang S, Zheng BJ, Zhou Y.

Virol J. 2010 Jan 18;7:9. doi: 10.1186/1743-422X-7-9.


Immunization with plasmid DNA encoding influenza A virus nucleoprotein fused to a tissue plasminogen activator signal sequence elicits strong immune responses and protection against H5N1 challenge in mice.

Luo M, Tao P, Li J, Zhou S, Guo D, Pan Z.

J Virol Methods. 2008 Dec;154(1-2):121-7. doi: 10.1016/j.jviromet.2008.08.011. Epub 2008 Sep 27.


A single immunization with HA DNA vaccine by electroporation induces early protection against H5N1 avian influenza virus challenge in mice.

Zheng L, Wang F, Yang Z, Chen J, Chang H, Chen Z.

BMC Infect Dis. 2009 Feb 12;9:17. doi: 10.1186/1471-2334-9-17.


Induction of protection against divergent H5N1 influenza viruses using a recombinant fusion protein linking influenza M2e to Onchocerca volvulus activation associated protein-1 (ASP-1) adjuvant.

Zhao G, Du L, Xiao W, Sun S, Lin Y, Chen M, Kou Z, He Y, Lustigman S, Jiang S, Zheng BJ, Zhou Y.

Vaccine. 2010 Oct 18;28(44):7233-40. doi: 10.1016/j.vaccine.2010.08.049. Epub 2010 Aug 21.


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