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Items: 1 to 20 of 98

1.

Amino acid residues responsible for the recognition of dichloroacetate by pyruvate dehydrogenase kinase 2.

Klyuyeva A, Tuganova A, Popov KM.

FEBS Lett. 2007 Jun 26;581(16):2988-92. Epub 2007 May 29.

2.

Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands.

Knoechel TR, Tucker AD, Robinson CM, Phillips C, Taylor W, Bungay PJ, Kasten SA, Roche TE, Brown DG.

Biochemistry. 2006 Jan 17;45(2):402-15. Erratum in: Biochemistry. 2006 Jul 18;45(28):8697-8.

PMID:
16401071
3.
4.

Dichloroacetate induces regulatory T-cell differentiation and suppresses Th17-cell differentiation by pyruvate dehydrogenase kinase-independent mechanism.

Makita N, Ishiguro J, Suzuki K, Nara F.

J Pharm Pharmacol. 2017 Jan;69(1):43-51. doi: 10.1111/jphp.12655. Epub 2016 Oct 19.

PMID:
27757958
5.

Allosteric coupling in pyruvate dehydrogenase kinase 2.

Klyuyeva A, Tuganova A, Popov KM.

Biochemistry. 2008 Aug 12;47(32):8358-66. doi: 10.1021/bi800631h. Epub 2008 Jul 16.

6.

Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate.

Li J, Kato M, Chuang DT.

J Biol Chem. 2009 Dec 4;284(49):34458-67. doi: 10.1074/jbc.M109.065557. Epub 2009 Oct 15.

8.

Differential inhibition of PDKs by phenylbutyrate and enhancement of pyruvate dehydrogenase complex activity by combination with dichloroacetate.

Ferriero R, Iannuzzi C, Manco G, Brunetti-Pierri N.

J Inherit Metab Dis. 2015 Sep;38(5):895-904. doi: 10.1007/s10545-014-9808-2. Epub 2015 Jan 20.

9.
10.

Studies on the regulation of the mitochondrial alpha-ketoacid dehydrogenase complexes and their kinases.

Harris RA, Hawes JW, Popov KM, Zhao Y, Shimomura Y, Sato J, Jaskiewicz J, Hurley TD.

Adv Enzyme Regul. 1997;37:271-93.

PMID:
9381974
11.

Unexpected Discovery of Dichloroacetate Derived Adenosine Triphosphate Competitors Targeting Pyruvate Dehydrogenase Kinase To Inhibit Cancer Proliferation.

Zhang SL, Hu X, Zhang W, Tam KY.

J Med Chem. 2016 Apr 14;59(7):3562-8. doi: 10.1021/acs.jmedchem.5b01828. Epub 2016 Mar 30.

PMID:
27006991
12.

Overexpression of pyruvate dehydrogenase kinase supports dichloroacetate as a candidate for cutaneous melanoma therapy.

Pópulo H, Caldas R, Lopes JM, Pardal J, Máximo V, Soares P.

Expert Opin Ther Targets. 2015 Jun;19(6):733-45. doi: 10.1517/14728222.2015.1045416.

PMID:
25976231
13.

Synergistic anticancer potential of dichloroacetate and estradiol analogue exerting their effect via ROS-JNK-Bcl-2-mediated signalling pathways.

Stander XX, Stander BA, Joubert AM.

Cell Physiol Biochem. 2015;35(4):1499-526. doi: 10.1159/000369710. Epub 2015 Mar 12.

14.

A new family of protein kinases--the mitochondrial protein kinases.

Harris RA, Popov KM, Zhao Y, Kedishvili NY, Shimomura Y, Crabb DW.

Adv Enzyme Regul. 1995;35:147-62.

PMID:
7572341
15.

Sepsis alters pyruvate dehydrogenase kinase activity in skeletal muscle.

Vary TC, Hazen S.

Mol Cell Biochem. 1999 Aug;198(1-2):113-8.

PMID:
10497885
16.

Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1.

Li W, James MO, McKenzie SC, Calcutt NA, Liu C, Stacpoole PW.

J Pharmacol Exp Ther. 2011 Jan;336(1):87-94. doi: 10.1124/jpet.110.173195. Epub 2010 Sep 30.

17.

Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1.

James MO, Jahn SC, Zhong G, Smeltz MG, Hu Z, Stacpoole PW.

Pharmacol Ther. 2017 Feb;170:166-180. doi: 10.1016/j.pharmthera.2016.10.018. Epub 2016 Oct 19. Review.

18.

Dichloroacetate, the Pyruvate Dehydrogenase Complex and the Modulation of mESC Pluripotency.

Rodrigues AS, Correia M, Gomes A, Pereira SL, Perestrelo T, Sousa MI, Ramalho-Santos J.

PLoS One. 2015 Jul 6;10(7):e0131663. doi: 10.1371/journal.pone.0131663. eCollection 2015.

19.

Ligand-induced effects on pyruvate dehydrogenase kinase isoform 2.

Hiromasa Y, Hu L, Roche TE.

J Biol Chem. 2006 May 5;281(18):12568-79. Epub 2006 Mar 3.

20.

Furoates and thenoates inhibit pyruvate dehydrogenase kinase 2 allosterically by binding to its pyruvate regulatory site.

Masini T, Birkaya B, van Dijk S, Mondal M, Hekelaar J, Jäger M, Terwisscha van Scheltinga AC, Patel MS, Hirsch AK, Moman E.

J Enzyme Inhib Med Chem. 2016;31(sup4):170-175. Epub 2016 Jul 19.

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