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ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL.

Ewings KE, Hadfield-Moorhouse K, Wiggins CM, Wickenden JA, Balmanno K, Gilley R, Degenhardt K, White E, Cook SJ.

EMBO J. 2007 Jun 20;26(12):2856-67. Epub 2007 May 24.


c-Cbl is not required for ERK1/2-dependent degradation of BimEL.

Wiggins CM, Band H, Cook SJ.

Cell Signal. 2007 Dec;19(12):2605-11. Epub 2007 Aug 23.


Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism.

Rahmani M, Aust MM, Attkisson E, Williams DC Jr, Ferreira-Gonzalez A, Grant S.

Cancer Res. 2013 Feb 15;73(4):1340-51. doi: 10.1158/0008-5472.CAN-12-1365. Epub 2012 Dec 12.


Activation of ERK1/2 by deltaRaf-1:ER* represses Bim expression independently of the JNK or PI3K pathways.

Weston CR, Balmanno K, Chalmers C, Hadfield K, Molton SA, Ley R, Wagner EF, Cook SJ.

Oncogene. 2003 Mar 6;22(9):1281-93.


Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover.

Ley R, Ewings KE, Hadfield K, Howes E, Balmanno K, Cook SJ.

J Biol Chem. 2004 Mar 5;279(10):8837-47. Epub 2003 Dec 17.


CDK1, not ERK1/2 or ERK5, is required for mitotic phosphorylation of BIMEL.

Gilley R, Lochhead PA, Balmanno K, Oxley D, Clark J, Cook SJ.

Cell Signal. 2012 Jan;24(1):170-80. doi: 10.1016/j.cellsig.2011.08.018. Epub 2011 Sep 8.


MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism.

Pei XY, Dai Y, Tenorio S, Lu J, Harada H, Dent P, Grant S.

Blood. 2007 Sep 15;110(6):2092-101. Epub 2007 May 31.


Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.

Ley R, Balmanno K, Hadfield K, Weston C, Cook SJ.

J Biol Chem. 2003 May 23;278(21):18811-6. Epub 2003 Mar 19.


Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.

Luciano F, Jacquel A, Colosetti P, Herrant M, Cagnol S, Pages G, Auberger P.

Oncogene. 2003 Oct 2;22(43):6785-93.


Refining the minimal sequence required for ERK1/2-dependent poly-ubiquitination and proteasome-dependent turnover of BIM.

Wiggins CM, Johnson M, Cook SJ.

Cell Signal. 2010 May;22(5):801-8. doi: 10.1016/j.cellsig.2010.01.004. Epub 2010 Jan 13.


c-Myc dependent expression of pro-apoptotic Bim renders HER2-overexpressing breast cancer cells dependent on anti-apoptotic Mcl-1.

Campone M, Noël B, Couriaud C, Grau M, Guillemin Y, Gautier F, Gouraud W, Charbonnel C, Campion L, Jézéquel P, Braun F, Barré B, Coqueret O, Barillé-Nion S, Juin P.

Mol Cancer. 2011 Sep 7;10:110. doi: 10.1186/1476-4598-10-110.


Trichonomas vaginalis metalloproteinase induces apoptosis of SiHa cells through disrupting the Mcl-1/Bim and Bcl-xL/Bim complexes.

Quan JH, Kang BH, Cha GH, Zhou W, Koh YB, Yang JB, Yoo HJ, Lee MA, Ryu JS, Noh HT, Kwon J, Lee YH.

PLoS One. 2014 Oct 24;9(10):e110659. doi: 10.1371/journal.pone.0110659. eCollection 2014.


Melphalan-induced apoptosis in multiple myeloma cells is associated with a cleavage of Mcl-1 and Bim and a decrease in the Mcl-1/Bim complex.

Gomez-Bougie P, Oliver L, Le Gouill S, Bataille R, Amiot M.

Oncogene. 2005 Dec 1;24(54):8076-9.


BIM(EL), an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation.

Wiggins CM, Tsvetkov P, Johnson M, Joyce CL, Lamb CA, Bryant NJ, Komander D, Shaul Y, Cook SJ.

J Cell Sci. 2011 Mar 15;124(Pt 6):969-77. doi: 10.1242/jcs.058438.


Interrelated roles for Mcl-1 and BIM in regulation of TRAIL-mediated mitochondrial apoptosis.

Han J, Goldstein LA, Gastman BR, Rabinowich H.

J Biol Chem. 2006 Apr 14;281(15):10153-63. Epub 2006 Feb 13.


Bim and the pro-survival Bcl-2 proteins: opposites attract, ERK repels.

Ewings KE, Wiggins CM, Cook SJ.

Cell Cycle. 2007 Sep 15;6(18):2236-40. Epub 2007 Jul 10. Review.


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