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Items: 1 to 20 of 269

1.

Molecular mechanisms of the diabetogenic effects of arsenic: inhibition of insulin signaling by arsenite and methylarsonous acid.

Paul DS, Harmon AW, Devesa V, Thomas DJ, Stýblo M.

Environ Health Perspect. 2007 May;115(5):734-42. Epub 2007 Jan 29.

2.

Inhibition of insulin-dependent glucose uptake by trivalent arsenicals: possible mechanism of arsenic-induced diabetes.

Walton FS, Harmon AW, Paul DS, Drobná Z, Patel YM, Styblo M.

Toxicol Appl Pharmacol. 2004 Aug 1;198(3):424-33.

PMID:
15276423
3.

Prolonged inorganic arsenite exposure suppresses insulin-stimulated AKT S473 phosphorylation and glucose uptake in 3T3-L1 adipocytes: involvement of the adaptive antioxidant response.

Xue P, Hou Y, Zhang Q, Woods CG, Yarborough K, Liu H, Sun G, Andersen ME, Pi J.

Biochem Biophys Res Commun. 2011 Apr 8;407(2):360-5. doi: 10.1016/j.bbrc.2011.03.024. Epub 2011 Mar 17.

4.

Membrane localization of 3-phosphoinositide-dependent protein kinase-1 stimulates activities of Akt and atypical protein kinase C but does not stimulate glucose transport and glycogen synthesis in 3T3-L1 adipocytes.

Egawa K, Maegawa H, Shi K, Nakamura T, Obata T, Yoshizaki T, Morino K, Shimizu S, Nishio Y, Suzuki E, Kashiwagi A.

J Biol Chem. 2002 Oct 11;277(41):38863-9. Epub 2002 Jul 29.

5.

Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes.

Ono H, Katagiri H, Funaki M, Anai M, Inukai K, Fukushima Y, Sakoda H, Ogihara T, Onishi Y, Fujishiro M, Kikuchi M, Oka Y, Asano T.

Mol Endocrinol. 2001 Aug;15(8):1411-22.

PMID:
11463863
6.

Postreceptoral adipocyte insulin resistance induced by nelfinavir is caused by insensitivity of PKB/Akt to phosphatidylinositol-3,4,5-trisphosphate.

Kachko I, Maissel A, Mazor L, Ben-Romano R, Watson RT, Hou JC, Pessin JE, Bashan N, Rudich A.

Endocrinology. 2009 Jun;150(6):2618-26. doi: 10.1210/en.2008-1205. Epub 2009 Jan 29.

7.

Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes.

Tremblay F, Gagnon A, Veilleux A, Sorisky A, Marette A.

Endocrinology. 2005 Mar;146(3):1328-37. Epub 2004 Dec 2.

PMID:
15576463
8.

Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake.

Green CJ, Göransson O, Kular GS, Leslie NR, Gray A, Alessi DR, Sakamoto K, Hundal HS.

J Biol Chem. 2008 Oct 10;283(41):27653-67. doi: 10.1074/jbc.M802623200. Epub 2008 Jul 31.

9.

PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes.

Tang X, Powelka AM, Soriano NA, Czech MP, Guilherme A.

J Biol Chem. 2005 Jun 10;280(23):22523-9. Epub 2005 Apr 11.

10.

Loss of PTEN expression does not contribute to PDK-1 activity and PKC activation-loop phosphorylation in Jurkat leukaemic T cells.

Freeley M, Park J, Yang KJ, Wange RL, Volkov Y, Kelleher D, Long A.

Cell Signal. 2007 Dec;19(12):2444-57. Epub 2007 Aug 3.

PMID:
17826953
11.

Role of PDK1 in insulin-signaling pathway for glucose metabolism in 3T3-L1 adipocytes.

Yamada T, Katagiri H, Asano T, Tsuru M, Inukai K, Ono H, Kodama T, Kikuchi M, Oka Y.

Am J Physiol Endocrinol Metab. 2002 Jun;282(6):E1385-94.

12.

Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells.

Jiang ZY, Zhou QL, Holik J, Patel S, Leszyk J, Coleman K, Chouinard M, Czech MP.

J Biol Chem. 2005 Jun 3;280(22):21622-8. Epub 2005 Mar 30.

13.

The effects of intracellular calcium depletion on insulin signaling in 3T3-L1 adipocytes.

Worrall DS, Olefsky JM.

Mol Endocrinol. 2002 Feb;16(2):378-89.

PMID:
11818508
15.

Requirement for 3-phosphoinositide-kependent dinase-1 (PDK-1) in insulin-induced glucose uptake in immortalized brown adipocytes.

Sakaue H, Nishizawa A, Ogawa W, Teshigawara K, Mori T, Takashima Y, Noda T, Kasuga M.

J Biol Chem. 2003 Oct 3;278(40):38870-4. Epub 2003 Jul 10.

16.

Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes.

Ugi S, Imamura T, Maegawa H, Egawa K, Yoshizaki T, Shi K, Obata T, Ebina Y, Kashiwagi A, Olefsky JM.

Mol Cell Biol. 2004 Oct;24(19):8778-89.

17.
18.

Methylated trivalent arsenicals are potent inhibitors of glucose stimulated insulin secretion by murine pancreatic islets.

Douillet C, Currier J, Saunders J, Bodnar WM, Matoušek T, Stýblo M.

Toxicol Appl Pharmacol. 2013 Feb 15;267(1):11-5. doi: 10.1016/j.taap.2012.12.007. Epub 2012 Dec 20.

19.

Requirement of atypical protein kinase clambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes.

Kotani K, Ogawa W, Matsumoto M, Kitamura T, Sakaue H, Hino Y, Miyake K, Sano W, Akimoto K, Ohno S, Kasuga M.

Mol Cell Biol. 1998 Dec;18(12):6971-82.

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