Sort by

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 412


Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production.

Yasuda K, Richez C, Maciaszek JW, Agrawal N, Akira S, Marshak-Rothstein A, Rifkin IR.

J Immunol. 2007 Jun 1;178(11):6876-85.


Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells.

Kerkmann M, Rothenfusser S, Hornung V, Towarowski A, Wagner M, Sarris A, Giese T, Endres S, Hartmann G.

J Immunol. 2003 May 1;170(9):4465-74.


TLR9/TLR7-triggered downregulation of BDCA2 expression on human plasmacytoid dendritic cells from healthy individuals and lupus patients.

Wu P, Wu J, Liu S, Han X, Lu J, Shi Y, Wang J, Lu L, Cao X.

Clin Immunol. 2008 Oct;129(1):40-8. doi: 10.1016/j.clim.2008.06.004.


U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7.

Savarese E, Chae OW, Trowitzsch S, Weber G, Kastner B, Akira S, Wagner H, Schmid RM, Bauer S, Krug A.

Blood. 2006 Apr 15;107(8):3229-34. Erratum in: Blood. 2006 May 15;107(10):3831.


IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9.

Hoshino K, Sugiyama T, Matsumoto M, Tanaka T, Saito M, Hemmi H, Ohara O, Akira S, Kaisho T.

Nature. 2006 Apr 13;440(7086):949-53.


Activation of invariant NKT cells by toll-like receptor 9-stimulated dendritic cells requires type I interferon and charged glycosphingolipids.

Paget C, Mallevaey T, Speak AO, Torres D, Fontaine J, Sheehan KC, Capron M, Ryffel B, Faveeuw C, Leite de Moraes M, Platt F, Trottein F.

Immunity. 2007 Oct;27(4):597-609.


Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus.

Barrat FJ, Meeker T, Gregorio J, Chan JH, Uematsu S, Akira S, Chang B, Duramad O, Coffman RL.

J Exp Med. 2005 Oct 17;202(8):1131-9.


IRF-7 is the master regulator of type-I interferon-dependent immune responses.

Honda K, Yanai H, Negishi H, Asagiri M, Sato M, Mizutani T, Shimada N, Ohba Y, Takaoka A, Yoshida N, Taniguchi T.

Nature. 2005 Apr 7;434(7034):772-7.


Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.

Christensen SR, Shupe J, Nickerson K, Kashgarian M, Flavell RA, Shlomchik MJ.

Immunity. 2006 Sep;25(3):417-28.


Conventional dendritic cells mount a type I IFN response against Candida spp. requiring novel phagosomal TLR7-mediated IFN-β signaling.

Bourgeois C, Majer O, Frohner IE, Lesiak-Markowicz I, Hildering KS, Glaser W, Stockinger S, Decker T, Akira S, Müller M, Kuchler K.

J Immunol. 2011 Mar 1;186(5):3104-12. doi: 10.4049/jimmunol.1002599.


Critical role of IkappaB Kinase alpha in TLR7/9-induced type I IFN production by conventional dendritic cells.

Hoshino K, Sasaki I, Sugiyama T, Yano T, Yamazaki C, Yasui T, Kikutani H, Kaisho T.

J Immunol. 2010 Apr 1;184(7):3341-5. doi: 10.4049/jimmunol.0901648.


Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes.

Boulé MW, Broughton C, Mackay F, Akira S, Marshak-Rothstein A, Rifkin IR.

J Exp Med. 2004 Jun 21;199(12):1631-40.


The IFN regulatory factor 7-dependent type I IFN response is not essential for early resistance against murine cytomegalovirus infection.

Steinberg C, Eisenächer K, Gross O, Reindl W, Schmitz F, Ruland J, Krug A.

Eur J Immunol. 2009 Apr;39(4):1007-18. doi: 10.1002/eji.200838814.


Negative regulation of TLR9-mediated IFN-alpha induction by a small-molecule, synthetic TLR7 ligand.

Marshall JD, Heeke DS, Gesner ML, Livingston B, Van Nest G.

J Leukoc Biol. 2007 Sep;82(3):497-508.


A compass that points to lupus: genetic studies on type I interferon pathway.

Kyogoku C, Tsuchiya N.

Genes Immun. 2007 Sep;8(6):445-55. Review.


"Endogenous adjuvant" activity of the RNA components of lupus autoantigens Sm/RNP and Ro 60.

Kelly KM, Zhuang H, Nacionales DC, Scumpia PO, Lyons R, Akaogi J, Lee P, Williams B, Yamamoto M, Akira S, Satoh M, Reeves WH.

Arthritis Rheum. 2006 May;54(5):1557-67.

Items per page

Supplemental Content

Support Center