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Items: 1 to 20 of 102

1.

Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo.

Chen Q, Espey MG, Sun AY, Lee JH, Krishna MC, Shacter E, Choyke PL, Pooput C, Kirk KL, Buettner GR, Levine M.

Proc Natl Acad Sci U S A. 2007 May 22;104(21):8749-54.

2.

Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues.

Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, Shacter E, Levine M.

Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13604-9.

3.

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice.

Chen Q, Espey MG, Sun AY, Pooput C, Kirk KL, Krishna MC, Khosh DB, Drisko J, Levine M.

Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11105-9. doi: 10.1073/pnas.0804226105.

4.

Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects.

Verrax J, Calderon PB.

Free Radic Biol Med. 2009 Jul 1;47(1):32-40. doi: 10.1016/j.freeradbiomed.2009.02.016.

PMID:
19254759
5.

Vitamin C: a concentration-function approach yields pharmacology and therapeutic discoveries.

Levine M, Padayatty SJ, Espey MG.

Adv Nutr. 2011 Mar;2(2):78-88. doi: 10.3945/an.110.000109. Review.

6.

Cytotoxic effects of high concentrations of sodium ascorbate on human myeloid cell lines.

Mastrangelo D, Massai L, Lo Coco F, Noguera NI, Borgia L, Fioritoni G, Berardi A, Iacone A, Muscettola M, Pelosi E, Castelli G, Testa U, Di Pisa F, Grasso G.

Ann Hematol. 2015 Nov;94(11):1807-16. doi: 10.1007/s00277-015-2464-2.

PMID:
26264692
7.

Oxygen dependency of one-electron reactions generating ascorbate radicals and hydrogen peroxide from ascorbic acid.

Boatright WL.

Food Chem. 2016 Apr 1;196:1361-7. doi: 10.1016/j.foodchem.2015.07.141.

PMID:
26593628
8.

Ascorbate potentiates DNA damage by 1-methyl-1-nitrosourea in vivo and generates DNA strand breaks in vitro.

Woolley PV, Kumar S, Fitzgerald P, Simpson RT.

Carcinogenesis. 1987 Nov;8(11):1657-62.

PMID:
2822277
9.

Direct evidence for recycling of myeloperoxidase-catalyzed phenoxyl radicals of a vitamin E homologue, 2,2,5,7,8-pentamethyl-6-hydroxy chromane, by ascorbate/dihydrolipoate in living HL-60 cells.

Kagan VE, Kuzmenko AI, Shvedova AA, Kisin ER, Li R, Martin I, Quinn PJ, Tyurin VA, Tyurina YY, Yalowich JC.

Biochim Biophys Acta. 2003 Mar 17;1620(1-3):72-84.

PMID:
12595076
10.

Parenteral ascorbate as a cancer therapeutic: a reassessment based on pharmacokinetics.

Parrow NL, Leshin JA, Levine M.

Antioxid Redox Signal. 2013 Dec 10;19(17):2141-56. doi: 10.1089/ars.2013.5372. Review.

11.

High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy.

Ma Y, Chapman J, Levine M, Polireddy K, Drisko J, Chen Q.

Sci Transl Med. 2014 Feb 5;6(222):222ra18. doi: 10.1126/scitranslmed.3007154.

12.

[An in vitro study on the pharmacological ascorbate treatment of influenza virus].

Cheng LL, Liu YY, Li B, Li SY, Ran PX.

Zhonghua Jie He He Hu Xi Za Zhi. 2012 Jul;35(7):520-3. Chinese.

PMID:
22931805
13.

Augmentation of respiratory tract lining fluid ascorbate concentrations through supplementation with vitamin C.

Behndig AF, Blomberg A, Helleday R, Kelly FJ, Mudway IS.

Inhal Toxicol. 2009 Feb;21(3):250-8. doi: 10.1080/08958370802474736 .

PMID:
19009458
14.
15.

Ascorbic acid: chemistry, biology and the treatment of cancer.

Du J, Cullen JJ, Buettner GR.

Biochim Biophys Acta. 2012 Dec;1826(2):443-57. doi: 10.1016/j.bbcan.2012.06.003. Review.

16.

H(2)O(2)-mediated cytotoxicity of pharmacologic ascorbate concentrations to neuroblastoma cells: potential role of lactate and ferritin.

Deubzer B, Mayer F, Ku├ži Z, Niewisch M, Merkel G, Handgretinger R, Bruchelt G.

Cell Physiol Biochem. 2010;25(6):767-74. doi: 10.1159/000315098.

17.

Mechanisms of ascorbate-induced cytotoxicity in pancreatic cancer.

Du J, Martin SM, Levine M, Wagner BA, Buettner GR, Wang SH, Taghiyev AF, Du C, Knudson CM, Cullen JJ.

Clin Cancer Res. 2010 Jan 15;16(2):509-20. doi: 10.1158/1078-0432.CCR-09-1713.

18.

Exercise training generates ascorbate free radical in rat heart.

Somani SM, Arroyo CM.

Indian J Physiol Pharmacol. 1995 Oct;39(4):323-9.

PMID:
8582743
20.

Radical formation in cytochrome c oxidase.

Yu MA, Egawa T, Shinzawa-Itoh K, Yoshikawa S, Yeh SR, Rousseau DL, Gerfen GJ.

Biochim Biophys Acta. 2011 Oct;1807(10):1295-304. doi: 10.1016/j.bbabio.2011.06.012.

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