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Items: 1 to 20 of 287

1.

Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment.

Ju Z, Jiang H, Jaworski M, Rathinam C, Gompf A, Klein C, Trumpp A, Rudolph KL.

Nat Med. 2007 Jun;13(6):742-7. Epub 2007 May 7.

PMID:
17486088
2.

Alterations of the systemic environment are the primary cause of impaired B and T lymphopoiesis in telomere-dysfunctional mice.

Song Z, Wang J, Guachalla LM, Terszowski G, Rodewald HR, Ju Z, Rudolph KL.

Blood. 2010 Feb 25;115(8):1481-9. doi: 10.1182/blood-2009-08-237230. Epub 2009 Dec 2.

3.

Telomere dysfunctional environment induces loss of quiescence and inherent impairments of hematopoietic stem cell function.

Song Z, Zhang J, Ju Z, Rudolph KL.

Aging Cell. 2012 Jun;11(3):449-55. doi: 10.1111/j.1474-9726.2012.00802.x. Epub 2012 Feb 22.

4.

Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation.

Allsopp RC, Morin GB, DePinho R, Harley CB, Weissman IL.

Blood. 2003 Jul 15;102(2):517-20. Epub 2003 Mar 27.

5.

Concise review: Telomere biology in normal and leukemic hematopoietic stem cells.

Drummond MW, Balabanov S, Holyoake TL, Brummendorf TH.

Stem Cells. 2007 Aug;25(8):1853-61. Epub 2007 May 17. Review.

6.

Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation.

Choudhury AR, Ju Z, Djojosubroto MW, Schienke A, Lechel A, Schaetzlein S, Jiang H, Stepczynska A, Wang C, Buer J, Lee HW, von Zglinicki T, Ganser A, Schirmacher P, Nakauchi H, Rudolph KL.

Nat Genet. 2007 Jan;39(1):99-105. Epub 2006 Dec 3.

PMID:
17143283
7.

Cell intrinsic and extrinsic mechanisms of stem cell aging depend on telomere status.

Song Z, Ju Z, Rudolph KL.

Exp Gerontol. 2009 Jan-Feb;44(1-2):75-82. doi: 10.1016/j.exger.2008.06.009. Epub 2008 Jul 3. Review.

PMID:
18640258
8.

Hematopoietic stem cells and the aging hematopoietic system.

Gazit R, Weissman IL, Rossi DJ.

Semin Hematol. 2008 Oct;45(4):218-24. doi: 10.1053/j.seminhematol.2008.07.010. Review.

PMID:
18809091
9.

Effects of telomerase modulation in human hematopoietic progenitor cells.

Zimmermann S, Glaser S, Ketteler R, Waller CF, Klingmüller U, Martens UM.

Stem Cells. 2004;22(5):741-9.

10.

Aging in the lympho-hematopoietic stem cell compartment.

Geiger H, Rudolph KL.

Trends Immunol. 2009 Jul;30(7):360-5. doi: 10.1016/j.it.2009.03.010. Epub 2009 Jun 18. Review.

PMID:
19540806
11.

Telomere shortening and oxidative stress in aged macrophages results in impaired STAT5a phosphorylation.

Sebastián C, Herrero C, Serra M, Lloberas J, Blasco MA, Celada A.

J Immunol. 2009 Aug 15;183(4):2356-64. doi: 10.4049/jimmunol.0901131. Epub 2009 Jul 15.

12.

Telomeres, senescence, and hematopoietic stem cells.

Zimmermann S, Martens UM.

Cell Tissue Res. 2008 Jan;331(1):79-90. Epub 2007 Oct 25. Review.

PMID:
17960423
13.

Telomere length, stem cells and aging.

Blasco MA.

Nat Chem Biol. 2007 Oct;3(10):640-9. Review.

PMID:
17876321
14.
15.

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing.

Wong KK, Maser RS, Bachoo RM, Menon J, Carrasco DR, Gu Y, Alt FW, DePinho RA.

Nature. 2003 Feb 6;421(6923):643-8. Epub 2003 Jan 22.

PMID:
12540856
16.

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age.

Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL.

Nature. 2007 Jun 7;447(7145):725-9.

PMID:
17554309
17.

Mobilization of hematopoietic stem cells during homeostasis and after cytokine exposure.

Abkowitz JL, Robinson AE, Kale S, Long MW, Chen J.

Blood. 2003 Aug 15;102(4):1249-53. Epub 2003 Apr 24.

18.
19.

Bone marrow-derived cells: the influence of aging and cellular senescence.

Beauséjour C.

Handb Exp Pharmacol. 2007;(180):67-88. Review.

PMID:
17554505
20.

Telomere dynamics in Fancg-deficient mouse and human cells.

Franco S, van de Vrugt HJ, Fernández P, Aracil M, Arwert F, Blasco MA.

Blood. 2004 Dec 15;104(13):3927-35. Epub 2004 Aug 19.

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