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Items: 1 to 20 of 173


Perforin-dependent cryptococcal microbicidal activity in NK cells requires PI3K-dependent ERK1/2 signaling.

Wiseman JC, Ma LL, Marr KJ, Jones GJ, Mody CH.

J Immunol. 2007 May 15;178(10):6456-64.


Requirement and redundancy of the Src family kinases Fyn and Lyn in perforin-dependent killing of Cryptococcus neoformans by NK cells.

Oykhman P, Timm-McCann M, Xiang RF, Islam A, Li SS, Stack D, Huston SM, Ma LL, Mody CH.

Infect Immun. 2013 Oct;81(10):3912-22. doi: 10.1128/IAI.00533-13. Epub 2013 Aug 5.


In contrast to anti-tumor activity, YT cell and primary NK cell cytotoxicity for Cryptococcus neoformans bypasses LFA-1.

Jones GJ, Wiseman JC, Marr KJ, Wei S, Djeu JY, Mody CH.

Int Immunol. 2009 Apr;21(4):423-32. doi: 10.1093/intimm/dxp010. Epub 2009 Mar 4.


Direct tumor lysis by NK cells uses a Ras-independent mitogen-activated protein kinase signal pathway.

Wei S, Gilvary DL, Corliss BC, Sebti S, Sun J, Straus DB, Leibson PJ, Trapani JA, Hamilton AD, Weber MJ, Djeu JY.

J Immunol. 2000 Oct 1;165(7):3811-9.


Cytotoxic CD4+ T cells use granulysin to kill Cryptococcus neoformans, and activation of this pathway is defective in HIV patients.

Zheng CF, Ma LL, Jones GJ, Gill MJ, Krensky AM, Kubes P, Mody CH.

Blood. 2007 Mar 1;109(5):2049-57. Epub 2006 Oct 12.


NK cells use perforin rather than granulysin for anticryptococcal activity.

Ma LL, Wang CL, Neely GG, Epelman S, Krensky AM, Mody CH.

J Immunol. 2004 Sep 1;173(5):3357-65.


An acidic microenvironment increases NK cell killing of Cryptococcus neoformans and Cryptococcus gattii by enhancing perforin degranulation.

Islam A, Li SS, Oykhman P, Timm-McCann M, Huston SM, Stack D, Xiang RF, Kelly MM, Mody CH.

PLoS Pathog. 2013;9(7):e1003439. doi: 10.1371/journal.ppat.1003439. Epub 2013 Jul 11.


Signaling pathways regulating CD44-dependent cytolysis in natural killer cells.

Sconocchia G, Titus JA, Segal DM.

Blood. 1997 Jul 15;90(2):716-25.


CD8 T cell-mediated killing of Cryptococcus neoformans requires granulysin and is dependent on CD4 T cells and IL-15.

Ma LL, Spurrell JC, Wang JF, Neely GG, Epelman S, Krensky AM, Mody CH.

J Immunol. 2002 Nov 15;169(10):5787-95.


Human umbilical cord blood NK T cells kill tumors by multiple cytotoxic mechanisms.

Gansuvd B, Hagihara M, Yu Y, Inoue H, Ueda Y, Tsuchiya T, Masui A, Ando K, Nakamura Y, Munkhtuvshin N, Kato S, Thomas JM, Hotta T.

Hum Immunol. 2002 Mar;63(3):164-75.


NK cell activation by dendritic cells is dependent on LFA-1-mediated induction of calcium-calmodulin kinase II: inhibition by HIV-1 Tat C-terminal domain.

Poggi A, Carosio R, Spaggiari GM, Fortis C, Tambussi G, Dell'Antonio G, Dal Cin E, Rubartelli A, Zocchi MR.

J Immunol. 2002 Jan 1;168(1):95-101.


Cryptococcus neoformans directly stimulates perforin production and rearms NK cells for enhanced anticryptococcal microbicidal activity.

Marr KJ, Jones GJ, Zheng C, Huston SM, Timm-McCann M, Islam A, Berenger BM, Ma LL, Wiseman JC, Mody CH.

Infect Immun. 2009 Jun;77(6):2436-46. doi: 10.1128/IAI.01232-08. Epub 2009 Mar 23.


Anticryptococcal cytotoxicity of murine nonadherent cells is perforin and nonperforin mediated.

Petković L, Arsenijević VA, Skvarc M, Kopitar A, Kotnik V, Simicic S, Wraber B, Matos T, Ihan A.

Mycologia. 2010 May-Jun;102(3):552-9.


Perforin-dependent and -independent pathways of cytotoxicity mediated by lymphocytes.

Young JD, Liu CC, Persechini PM, Cohn ZA.

Immunol Rev. 1988 Mar;103:161-202. Review.


Interferon-gamma-induced membrane PAF-receptor expression confers tumor cell susceptibility to NK perforin-dependent lysis.

Berthou C, Bourge JF, Zhang Y, Soulié A, Geromin D, Denizot Y, Sigaux F, Sasportes M.

Blood. 2000 Apr 1;95(7):2329-36.


Mechanisms by Which Interleukin-12 Corrects Defective NK Cell Anticryptococcal Activity in HIV-Infected Patients.

Kyei SK, Ogbomo H, Li S, Timm-McCann M, Xiang RF, Huston SM, Ganguly A, Colarusso P, Gill MJ, Mody CH.

MBio. 2016 Aug 23;7(4). pii: e00878-16. doi: 10.1128/mBio.00878-16.


Syk regulation of phosphoinositide 3-kinase-dependent NK cell function.

Jiang K, Zhong B, Gilvary DL, Corliss BC, Vivier E, Hong-Geller E, Wei S, Djeu JY.

J Immunol. 2002 Apr 1;168(7):3155-64.


KHYG-1, a model for the study of enhanced natural killer cell cytotoxicity.

Suck G, Branch DR, Smyth MJ, Miller RG, Vergidis J, Fahim S, Keating A.

Exp Hematol. 2005 Oct;33(10):1160-71.


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