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Items: 1 to 20 of 60

1.

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes.

Steinthorsdottir V, Thorleifsson G, Reynisdottir I, Benediktsson R, Jonsdottir T, Walters GB, Styrkarsdottir U, Gretarsdottir S, Emilsson V, Ghosh S, Baker A, Snorradottir S, Bjarnason H, Ng MC, Hansen T, Bagger Y, Wilensky RL, Reilly MP, Adeyemo A, Chen Y, Zhou J, Gudnason V, Chen G, Huang H, Lashley K, Doumatey A, So WY, Ma RC, Andersen G, Borch-Johnsen K, Jorgensen T, van Vliet-Ostaptchouk JV, Hofker MH, Wijmenga C, Christiansen C, Rader DJ, Rotimi C, Gurney M, Chan JC, Pedersen O, Sigurdsson G, Gulcher JR, Thorsteinsdottir U, Kong A, Stefansson K.

Nat Genet. 2007 Jun;39(6):770-5. Epub 2007 Apr 26.

PMID:
17460697
2.
3.

Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals.

Saxena R, Gianniny L, Burtt NP, Lyssenko V, Giuducci C, Sjögren M, Florez JC, Almgren P, Isomaa B, Orho-Melander M, Lindblad U, Daly MJ, Tuomi T, Hirschhorn JN, Ardlie KG, Groop LC, Altshuler D.

Diabetes. 2006 Oct;55(10):2890-5.

4.

Association study of the genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene and type 2 diabetes in the Chinese population.

Chang YC, Chang TJ, Jiang YD, Kuo SS, Lee KC, Chiu KC, Chuang LM.

Diabetes. 2007 Oct;56(10):2631-7. Epub 2007 Jun 19.

5.

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.

Lyssenko V, Lupi R, Marchetti P, Del Guerra S, Orho-Melander M, Almgren P, Sjögren M, Ling C, Eriksson KF, Lethagen AL, Mancarella R, Berglund G, Tuomi T, Nilsson P, Del Prato S, Groop L.

J Clin Invest. 2007 Aug;117(8):2155-63.

6.

Association of TCF7L2 polymorphism with diabetes mellitus, metabolic syndrome, and markers of beta cell function and insulin resistance in a population-based sample of Emirati subjects.

Saadi H, Nagelkerke N, Carruthers SG, Benedict S, Abdulkhalek S, Reed R, Lukic M, Nicholls MG.

Diabetes Res Clin Pract. 2008 Jun;80(3):392-8. doi: 10.1016/j.diabres.2008.01.008. Epub 2008 Feb 20.

PMID:
18282631
7.

Association of sterol regulatory element-binding protein-1c gene polymorphism with type 2 diabetes mellitus, insulin resistance and blood lipid levels in Chinese population.

Liu JX, Liu J, Li PQ, Xie XD, Guo Q, Tian LM, Ma XQ, Zhang JP, Liu J, Gao JY.

Diabetes Res Clin Pract. 2008 Oct;82(1):42-7. doi: 10.1016/j.diabres.2008.06.017. Epub 2008 Aug 8.

PMID:
18692268
8.

Common coding variant in the TCF7L2 gene and study of the association with type 2 diabetes in Japanese subjects.

Kunika K, Tanahashi T, Numata S, Ueno S, Ohmori T, Nakamura N, Tsugawa K, Miyawaki K, Moritani M, Inoue H, Itakura M.

J Hum Genet. 2008;53(11-12):972-82. doi: 10.1007/s10038-008-0339-2. Epub 2008 Nov 18.

PMID:
19012045
9.

Whole-grain consumption and transcription factor-7-like 2 ( TCF7L2) rs7903146: gene-diet interaction in modulating type 2 diabetes risk.

Fisher E, Boeing H, Fritsche A, Doering F, Joost HG, Schulze MB.

Br J Nutr. 2009 Feb;101(4):478-81. doi: 10.1017/S0007114508020369. Epub 2008 Jul 17.

PMID:
19149908
10.

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes.

Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, Helgason A, Stefansson H, Emilsson V, Helgadottir A, Styrkarsdottir U, Magnusson KP, Walters GB, Palsdottir E, Jonsdottir T, Gudmundsdottir T, Gylfason A, Saemundsdottir J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Gudnason V, Sigurdsson G, Thorsteinsdottir U, Gulcher JR, Kong A, Stefansson K.

Nat Genet. 2006 Mar;38(3):320-3. Epub 2006 Jan 15.

PMID:
16415884
11.

A common functional exon polymorphism in the microsomal triglyceride transfer protein gene is associated with type 2 diabetes, impaired glucose metabolism and insulin levels.

Rubin D, Helwig U, Pfeuffer M, Schreiber S, Boeing H, Fisher E, Pfeiffer A, Freitag-Wolf S, Foelsch UR, Doering F, Schrezenmeir J.

J Hum Genet. 2006;51(6):567-74. Epub 2006 May 24.

PMID:
16721486
12.

Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men.

Zhang C, Qi L, Hunter DJ, Meigs JB, Manson JE, van Dam RM, Hu FB.

Diabetes. 2006 Sep;55(9):2645-8.

13.

Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population.

Alsmadi O, Al-Rubeaan K, Mohamed G, Alkayal F, Al-Saud H, Al-Saud NA, Al-Daghri N, Mohammad S, Meyer BF.

BMC Med Genet. 2008 Jul 26;9:72. doi: 10.1186/1471-2350-9-72.

14.

TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study.

Cauchi S, Meyre D, Choquet H, Dina C, Born C, Marre M, Balkau B, Froguel P; DESIR Study Group.

Diabetes. 2006 Nov;55(11):3189-92. Erratum in: Diabetes. 2006 Dec;55(12):3635.

15.

Replication and identification of novel variants at TCF7L2 associated with type 2 diabetes in Hong Kong Chinese.

Ng MC, Tam CH, Lam VK, So WY, Ma RC, Chan JC.

J Clin Endocrinol Metab. 2007 Sep;92(9):3733-7. Epub 2007 Jul 3.

PMID:
17609304
16.

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution.

Helgason A, Pálsson S, Thorleifsson G, Grant SF, Emilsson V, Gunnarsdottir S, Adeyemo A, Chen Y, Chen G, Reynisdottir I, Benediktsson R, Hinney A, Hansen T, Andersen G, Borch-Johnsen K, Jorgensen T, Schäfer H, Faruque M, Doumatey A, Zhou J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Sigurdsson G, Hebebrand J, Pedersen O, Thorsteinsdottir U, Gulcher JR, Kong A, Rotimi C, Stefánsson K.

Nat Genet. 2007 Feb;39(2):218-25. Epub 2007 Jan 7.

PMID:
17206141
17.

CHOP T/C and C/T haplotypes contribute to early-onset type 2 diabetes in Italians.

Gragnoli C.

J Cell Physiol. 2008 Nov;217(2):291-5. doi: 10.1002/jcp.21553.

PMID:
18680108
18.

Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with reduced insulin secretion in nondiabetic women.

Munoz J, Lok KH, Gower BA, Fernandez JR, Hunter GR, Lara-Castro C, De Luca M, Garvey WT.

Diabetes. 2006 Dec;55(12):3630-4.

19.

Type 2 diabetes gene TCF7L2 polymorphism is not associated with fetal and postnatal growth in two birth cohort studies.

Mook-Kanamori DO, de Kort SW, van Duijn CM, Uitterlinden AG, Hofman A, Moll HA, Steegers EA, Hokken-Koelega AC, Jaddoe VW.

BMC Med Genet. 2009 Jul 17;10:67. doi: 10.1186/1471-2350-10-67.

20.

Association of TCF7L2 polymorphisms with type 2 diabetes in Mexico City.

Parra EJ, Cameron E, Simmonds L, Valladares A, McKeigue P, Shriver M, Wacher N, Kumate J, Kittles R, Cruz M.

Clin Genet. 2007 Apr;71(4):359-66.

PMID:
17470138

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