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Items: 1 to 20 of 122

1.

Complex translational regulation of BACE1 involves upstream AUGs and stimulatory elements within the 5' untranslated region.

Mihailovich M, Thermann R, Grohovaz F, Hentze MW, Zacchetti D.

Nucleic Acids Res. 2007;35(9):2975-85. Epub 2007 Apr 16.

2.

Leaky scanning and reinitiation regulate BACE1 gene expression.

Zhou W, Song W.

Mol Cell Biol. 2006 May;26(9):3353-64.

3.

Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region.

Lammich S, Schöbel S, Zimmer AK, Lichtenthaler SF, Haass C.

EMBO Rep. 2004 Jun;5(6):620-5. Epub 2004 May 28.

4.

Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease.

Rossner S, Sastre M, Bourne K, Lichtenthaler SF.

Prog Neurobiol. 2006 Jun;79(2):95-111. Epub 2006 Aug 14. Review.

PMID:
16904810
5.
6.
7.

DNA methylation of the 5'-untranslated region at +298 and +351 represses BACE1 expression in mouse BV-2 microglial cells.

Byun CJ, Seo J, Jo SA, Park YJ, Klug M, Rehli M, Park MH, Jo I.

Biochem Biophys Res Commun. 2012 Jan 6;417(1):387-92. doi: 10.1016/j.bbrc.2011.11.123. Epub 2011 Dec 6.

PMID:
22166205
8.

Identification of a cis-acting element involved in the regulation of BACE1 mRNA alternative splicing.

Mowrer KR, Wolfe MS.

J Neurochem. 2009 May;109(4):1008-16. doi: 10.1111/j.1471-4159.2009.06026.x. Epub 2009 Mar 3.

10.

Promotion of BACE1 mRNA alternative splicing reduces amyloid beta-peptide production.

Mowrer KR, Wolfe MS.

J Biol Chem. 2008 Jul 4;283(27):18694-701. doi: 10.1074/jbc.M801322200. Epub 2008 May 8.

11.

APP and BACE1 miRNA genetic variability has no major role in risk for Alzheimer disease.

Bettens K, Brouwers N, Engelborghs S, Van Miegroet H, De Deyn PP, Theuns J, Sleegers K, Van Broeckhoven C.

Hum Mutat. 2009 Aug;30(8):1207-13. doi: 10.1002/humu.21027.

PMID:
19462468
12.

Translational control of BACE1 may go awry in Alzheimer's disease.

Wong PC.

Neuron. 2008 Dec 26;60(6):941-3. doi: 10.1016/j.neuron.2008.12.010.

13.

In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.

Sankaranarayanan S, Price EA, Wu G, Crouthamel MC, Shi XP, Tugusheva K, Tyler KX, Kahana J, Ellis J, Jin L, Steele T, Stachel S, Coburn C, Simon AJ.

J Pharmacol Exp Ther. 2008 Mar;324(3):957-69. Epub 2007 Dec 21.

14.

NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42.

Buggia-Prevot V, Sevalle J, Rossner S, Checler F.

J Biol Chem. 2008 Apr 11;283(15):10037-47. doi: 10.1074/jbc.M706579200. Epub 2008 Feb 8.

15.

The integrated role of desferrioxamine and phenserine targeted to an iron-responsive element in the APP-mRNA 5'-untranslated region.

Venti A, Giordano T, Eder P, Bush AI, Lahiri DK, Greig NH, Rogers JT.

Ann N Y Acad Sci. 2004 Dec;1035:34-48.

PMID:
15681799
16.

BACE1 structure and function in health and Alzheimer's disease.

Cole SL, Vassar R.

Curr Alzheimer Res. 2008 Apr;5(2):100-20. Review.

PMID:
18393796
17.

Disrupted intracellular calcium regulates BACE1 gene expression via nuclear factor of activated T cells 1 (NFAT 1) signaling.

Cho HJ, Jin SM, Youn HD, Huh K, Mook-Jung I.

Aging Cell. 2008 Mar;7(2):137-47. Epub 2007 Dec 5.

18.

BACE1 is a newly discovered protein secreted by the pancreas which cleaves enteropeptidase in vitro.

Hoffmeister A, Dietz G, Zeitschel U, Mössner J, Rossner S, Stahl T.

JOP. 2009 Sep 4;10(5):501-6.

19.

Characterization of the 5'-untranslated region of YB-1 mRNA and autoregulation of translation by YB-1 protein.

Fukuda T, Ashizuka M, Nakamura T, Shibahara K, Maeda K, Izumi H, Kohno K, Kuwano M, Uchiumi T.

Nucleic Acids Res. 2004 Jan 29;32(2):611-22. Print 2004.

20.

BACE1 polymorphisms do not influence platelet membrane beta-secretase activity or genetic susceptibility for Alzheimer's disease in the Northern Irish population.

Todd S, McKnight AJ, Liu WW, Carson R, Heggarty S, McGuinness B, Irvine GB, Craig D, Passmore AP, Johnston JA.

Neuromolecular Med. 2008;10(4):368-76. doi: 10.1007/s12017-008-8045-y. Epub 2008 Jun 26.

PMID:
18581272

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