Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 117


Malaria-infected mice are cured by a single dose of novel artemisinin derivatives.

Posner GH, Paik IH, Chang W, Borstnik K, Sinishtaj S, Rosenthal AS, Shapiro TA.

J Med Chem. 2007 May 17;50(10):2516-9. Epub 2007 Apr 17.


Malaria-infected mice are cured by oral administration of new artemisinin derivatives.

Posner GH, Chang W, Hess L, Woodard L, Sinishtaj S, Usera AR, Maio W, Rosenthal AS, Kalinda AS, D'Angelo JG, Petersen KS, Stohler R, Chollet J, Santo-Tomas J, Snyder C, Rottmann M, Wittlin S, Brun R, Shapiro TA.

J Med Chem. 2008 Feb 28;51(4):1035-42. doi: 10.1021/jm701168h. Epub 2008 Jan 31.


Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacy.

Posner GH, Paik IH, Sur S, McRiner AJ, Borstnik K, Xie S, Shapiro TA.

J Med Chem. 2003 Mar 13;46(6):1060-5.


The survival times of malaria-infected mice are prolonged more by several new two-carbon-linked artemisinin-derived dimer carbamates than by the trioxane antimalarial drug artemether.

Conyers RC, Mazzone JR, Siegler MA, Tripathi AK, Sullivan DJ, Mott BT, Posner GH.

Bioorg Med Chem Lett. 2014 Mar 1;24(5):1285-9. doi: 10.1016/j.bmcl.2014.01.059. Epub 2014 Jan 30.


Antimalarial chemotherapy: artemisinin-derived dimer carbonates and thiocarbonates.

Mazzone JR, Conyers RC, Tripathi AK, Sullivan DJ, Posner GH.

Bioorg Med Chem Lett. 2014 Jun 1;24(11):2440-3. doi: 10.1016/j.bmcl.2014.04.025. Epub 2014 Apr 16.


A single, low, oral dose of a 5-carbon-linked trioxane dimer orthoester plus mefloquine cures malaria-infected mice.

Moon DK, Tripathi A, Sullivan D, Siegler MA, Parkin S, Posner GH.

Bioorg Med Chem Lett. 2011 May 1;21(9):2773-5. doi: 10.1016/j.bmcl.2010.09.123. Epub 2010 Sep 29.


Antimalarial chemotherapy: orally curative artemisinin-derived trioxane dimer esters.

Conyers RC, Mazzone JR, Tripathi AK, Sullivan DJ, Posner GH.

Bioorg Med Chem Lett. 2015 Jan 15;25(2):245-8. doi: 10.1016/j.bmcl.2014.11.064. Epub 2014 Nov 27.


Malaria-infected mice are completely cured by one 6 mg/kg oral dose of a new monomeric trioxane sulfide combined with mefloquine.

Slack RD, Mott BT, Woodard LE, Tripathi A, Sullivan D, Nenortas E, Girdwood SC, Shapiro TA, Posner GH.

J Med Chem. 2012 Jan 12;55(1):291-6. doi: 10.1021/jm201214d. Epub 2011 Dec 15. Erratum in: J Med Chem. 2012 Feb 23;55(4):1788. Triphati, Abhai [corrected to Tripathi, Abhai].


Orally active antimalarial 3-substituted trioxanes: new synthetic methodology and biological evaluation.

Posner GH, Cumming JN, Woo SH, Ploypradith P, Xie S, Shapiro TA.

J Med Chem. 1998 Mar 12;41(6):940-51.


The chemotherapy of rodent malaria. LX. The importance of formulation in evaluating the blood schizontocidal activity of some endoperoxide antimalarials.

Peters W, Fleck SL, Robinson BL, Stewart LB, Jefford CW.

Ann Trop Med Parasitol. 2002 Sep;96(6):559-73.


New, antimalarial, tricyclic 1,2,4-trioxanes: evaluations in mice and monkeys.

Posner GH, Oh CH, Webster HK, Ager AL Jr, Rossan RN.

Am J Trop Med Hyg. 1994 Apr;50(4):522-6.


Artemisinin derivatives bearing Mannich base group: synthesis and antimalarial activity.

Li Y, Yang ZS, Zhang H, Cao BJ, Wang FD, Zhang Y, Shi YL, Yang JD, Wu BA.

Bioorg Med Chem. 2003 Oct 1;11(20):4363-8.


Synthesis and antimalarial efficacy of two-carbon-linked, artemisinin-derived trioxane dimers in combination with known antimalarial drugs.

Mott BT, Tripathi A, Siegler MA, Moore CD, Sullivan DJ, Posner GH.

J Med Chem. 2013 Mar 28;56(6):2630-41. doi: 10.1021/jm400058j. Epub 2013 Mar 7.


New orally active derivatives of artemisinin with high efficacy against multidrug-resistant malaria in mice.

Singh C, Chaudhary S, Puri SK.

J Med Chem. 2006 Nov 30;49(24):7227-33.


The quest for affordable artemisinin.

Cook SP.

Future Med Chem. 2013 Mar;5(3):233-6. doi: 10.4155/fmc.13.1. No abstract available.


Orally active antimalarials: hydrolytically stable derivatives of 10-trifluoromethyl anhydrodihydroartemisinin.

Grellepois F, Chorki F, Ourévitch M, Charneau S, Grellier P, McIntosh KA, Charman WN, Pradines B, Crousse B, Bonnet-Delpon D, Bégué JP.

J Med Chem. 2004 Mar 11;47(6):1423-33.


Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells.

Rosenthal AS, Chen X, Liu JO, West DC, Hergenrother PJ, Shapiro TA, Posner GH.

J Med Chem. 2009 Feb 26;52(4):1198-203. doi: 10.1021/jm801484v.


Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria.

Charman SA, Arbe-Barnes S, Bathurst IC, Brun R, Campbell M, Charman WN, Chiu FC, Chollet J, Craft JC, Creek DJ, Dong Y, Matile H, Maurer M, Morizzi J, Nguyen T, Papastogiannidis P, Scheurer C, Shackleford DM, Sriraghavan K, Stingelin L, Tang Y, Urwyler H, Wang X, White KL, Wittlin S, Zhou L, Vennerstrom JL.

Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4400-5. doi: 10.1073/pnas.1015762108. Epub 2011 Feb 7.


Malaria-infected mice live until at least day 30 after a new artemisinin-derived thioacetal thiocarbonate combined with mefloquine are administered together in a single, low, oral dose.

Jacobine AM, Mazzone JR, Slack RD, Tripathi AK, Sullivan DJ, Posner GH.

J Med Chem. 2012 Sep 13;55(17):7892-9. doi: 10.1021/jm3009986. Epub 2012 Aug 27.


Fluoroartemisinin: trifluoromethyl analogues of artemether and artesunate.

Magueur G, Crousse B, Charneau S, Grellier P, Bégué JP, Bonnet-Delpon D.

J Med Chem. 2004 May 6;47(10):2694-9.


Supplemental Content

Support Center