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SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70.

Sundaresan NR, Samant SA, Pillai VB, Rajamohan SB, Gupta MP.

Mol Cell Biol. 2008 Oct;28(20):6384-401. doi: 10.1128/MCB.00426-08. Epub 2008 Aug 18.


Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5.

Nakamura Y, Ogura M, Tanaka D, Inagaki N.

Biochem Biophys Res Commun. 2008 Feb 1;366(1):174-9. Epub 2007 Dec 3.


SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria.

Onyango P, Celic I, McCaffery JM, Boeke JD, Feinberg AP.

Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13653-8. Epub 2002 Oct 8.


The human SIRT3 protein deacetylase is exclusively mitochondrial.

Cooper HM, Spelbrink JN.

Biochem J. 2008 Apr 15;411(2):279-85. doi: 10.1042/BJ20071624.


Where in the cell is SIRT3?--functional localization of an NAD+-dependent protein deacetylase.

Hallows WC, Albaugh BN, Denu JM.

Biochem J. 2008 Apr 15;411(2):e11-3. doi: 10.1042/BJ20080336.


SIRT3 functions in the nucleus in the control of stress-related gene expression.

Iwahara T, Bonasio R, Narendra V, Reinberg D.

Mol Cell Biol. 2012 Dec;32(24):5022-34. doi: 10.1128/MCB.00822-12. Epub 2012 Oct 8.


Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.

Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV Jr, Weissman S, Verdin E, Schwer B.

Mol Cell Biol. 2007 Dec;27(24):8807-14. Epub 2007 Oct 8.


Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3.

Jin L, Galonek H, Israelian K, Choy W, Morrison M, Xia Y, Wang X, Xu Y, Yang Y, Smith JJ, Hoffmann E, Carney DP, Perni RB, Jirousek MR, Bemis JE, Milne JC, Sinclair DA, Westphal CH.

Protein Sci. 2009 Mar;18(3):514-25. doi: 10.1002/pro.50.


SIRT3 SNPs validation in 640 individuals, functional analyses and new insights into SIRT3 stability.

Dransfeld CL, Alborzinia H, Wölfl S, Mahlknecht U.

Int J Oncol. 2010 Apr;36(4):955-60.


Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5.

Schlicker C, Gertz M, Papatheodorou P, Kachholz B, Becker CF, Steegborn C.

J Mol Biol. 2008 Oct 10;382(3):790-801. doi: 10.1016/j.jmb.2008.07.048. Epub 2008 Jul 25.


SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression.

Jacobs KM, Pennington JD, Bisht KS, Aykin-Burns N, Kim HS, Mishra M, Sun L, Nguyen P, Ahn BH, Leclerc J, Deng CX, Spitz DR, Gius D.

Int J Biol Sci. 2008 Sep 5;4(5):291-9.


Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin.

Vaquero A, Scher M, Lee D, Erdjument-Bromage H, Tempst P, Reinberg D.

Mol Cell. 2004 Oct 8;16(1):93-105.


Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins.

Law IK, Liu L, Xu A, Lam KS, Vanhoutte PM, Che CM, Leung PT, Wang Y.

Proteomics. 2009 May;9(9):2444-56. doi: 10.1002/pmic.200800738.


A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis.

Ahn BH, Kim HS, Song S, Lee IH, Liu J, Vassilopoulos A, Deng CX, Finkel T.

Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14447-52. doi: 10.1073/pnas.0803790105. Epub 2008 Sep 15.


Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2.

Schwer B, Bunkenborg J, Verdin RO, Andersen JS, Verdin E.

Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10224-9. Epub 2006 Jun 20.


Function of sirtuins in biological tissues.

Shoba B, Lwin ZM, Ling LS, Bay BH, Yip GW, Kumar SD.

Anat Rec (Hoboken). 2009 Apr;292(4):536-43. doi: 10.1002/ar.20875. Review.


Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization.

Yang W, Nagasawa K, Münch C, Xu Y, Satterstrom K, Jeong S, Hayes SD, Jedrychowski MP, Vyas FS, Zaganjor E, Guarani V, Ringel AE, Gygi SP, Harper JW, Haigis MC.

Cell. 2016 Nov 3;167(4):985-1000.e21. doi: 10.1016/j.cell.2016.10.016. Epub 2016 Oct 27.


Mitochondrial metabolism, sirtuins, and aging.

Sack MN, Finkel T.

Cold Spring Harb Perspect Biol. 2012 Dec 1;4(12). pii: a013102. doi: 10.1101/cshperspect.a013102. Review.

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