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Loss of integrin linked kinase from mouse hepatocytes in vitro and in vivo results in apoptosis and hepatitis.

Gkretsi V, Mars WM, Bowen WC, Barua L, Yang Y, Guo L, St-Arnaud R, Dedhar S, Wu C, Michalopoulos GK.

Hepatology. 2007 Apr;45(4):1025-34.


Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly.

Gkretsi V, Apte U, Mars WM, Bowen WC, Luo JH, Yang Y, Yu YP, Orr A, St-Arnaud R, Dedhar S, Kaestner KH, Wu C, Michalopoulos GK.

Hepatology. 2008 Dec;48(6):1932-41. doi: 10.1002/hep.22537.


Integrin-linked kinase is involved in matrix-induced hepatocyte differentiation.

Gkretsi V, Bowen WC, Yang Y, Wu C, Michalopoulos GK.

Biochem Biophys Res Commun. 2007 Feb 16;353(3):638-43. Epub 2006 Dec 20.


Molecular dissection of the ILK-PINCH-parvin triad reveals a fundamental role for the ILK kinase domain in the late stages of focal-adhesion maturation.

Stanchi F, Grashoff C, Nguemeni Yonga CF, Grall D, Fässler R, Van Obberghen-Schilling E.

J Cell Sci. 2009 Jun 1;122(Pt 11):1800-11. doi: 10.1242/jcs.044602. Epub 2009 May 12.


The integrin-linked kinase-PINCH-parvin complex supports integrin αIIbβ3 activation.

Honda S, Shirotani-Ikejima H, Tadokoro S, Tomiyama Y, Miyata T.

PLoS One. 2013 Dec 23;8(12):e85498. doi: 10.1371/journal.pone.0085498. eCollection 2013.


RGD peptides confer survival to hepatocytes via the beta1-integrin-ILK-pAkt pathway.

Pinkse GG, Jiawan-Lalai R, Bruijn JA, de Heer E.

J Hepatol. 2005 Jan;42(1):87-93.


Integrin-linked kinase regulates migration and proliferation of human intestinal cells under a fibronectin-dependent mechanism.

Gagné D, Groulx JF, Benoit YD, Basora N, Herring E, Vachon PH, Beaulieu JF.

J Cell Physiol. 2010 Feb;222(2):387-400. doi: 10.1002/jcp.21963.


Role of PINCH and its partner tumor suppressor Rsu-1 in regulating liver size and tumorigenesis.

Donthamsetty S, Bhave VS, Mars WM, Bowen WC, Orr A, Haynes MM, Wu C, Michalopoulos GK.

PLoS One. 2013 Sep 18;8(9):e74625. doi: 10.1371/journal.pone.0074625. eCollection 2013.


Significance of thymosin β4 and implication of PINCH-1-ILK-α-parvin (PIP) complex in human dilated cardiomyopathy.

Sopko N, Qin Y, Finan A, Dadabayev A, Chigurupati S, Qin J, Penn MS, Gupta S.

PLoS One. 2011;6(5):e20184. doi: 10.1371/journal.pone.0020184. Epub 2011 May 19.


Regulation of fibronectin matrix deposition and cell proliferation by the PINCH-ILK-CH-ILKBP complex.

Guo L, Wu C.

FASEB J. 2002 Aug;16(10):1298-300. Epub 2002 Jun 7.


The PINCH-ILK-parvin complexes: assembly, functions and regulation.

Wu C.

Biochim Biophys Acta. 2004 Jul 5;1692(2-3):55-62. Review.


Excessive hepatomegaly of mice with hepatocyte-targeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene.

Donthamsetty S, Bhave VS, Kliment CS, Bowen WC, Mars WM, Bell AW, Stewart RE, Orr A, Wu C, Michalopoulos GK.

Hepatology. 2011 Feb;53(2):587-95. doi: 10.1002/hep.24040. Epub 2011 Jan 6. Erratum in: Hepatology. 2014 Aug;60(2):771.


Targeted deletion of integrin-linked kinase reveals a role in T-cell chemotaxis and survival.

Liu E, Sinha S, Williams C, Cyrille M, Heller E, Snapper SB, Georgopoulos K, St-Arnaud R, Force T, Dedhar S, Gerszten RE.

Mol Cell Biol. 2005 Dec;25(24):11145-55.


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