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Items: 1 to 20 of 82

1.

The role of ascorbate in the modulation of HIF-1alpha protein and HIF-dependent transcription by chromium(VI) and nickel(II).

Kaczmarek M, Timofeeva OA, Karaczyn A, Malyguine A, Kasprzak KS, Salnikow K.

Free Radic Biol Med. 2007 Apr 15;42(8):1246-57. Epub 2007 Jan 19.

2.

Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress.

Salnikow K, Donald SP, Bruick RK, Zhitkovich A, Phang JM, Kasprzak KS.

J Biol Chem. 2004 Sep 24;279(39):40337-44. Epub 2004 Jul 22.

3.

Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1alpha) and HIF-regulated genes.

Li Q, Chen H, Huang X, Costa M.

Toxicol Appl Pharmacol. 2006 Jun 15;213(3):245-55. Epub 2006 Jan 4.

4.

Ascorbate depletion mediates up-regulation of hypoxia-associated proteins by cell density and nickel.

Karaczyn A, Ivanov S, Reynolds M, Zhitkovich A, Kasprzak KS, Salnikow K.

J Cell Biochem. 2006 Apr 1;97(5):1025-35.

PMID:
16288478
5.

Signal transducer and activator of transcription 1 (STAT1) is essential for chromium silencing of gene induction in human airway epithelial cells.

Nemec AA, Barchowsky A.

Toxicol Sci. 2009 Jul;110(1):212-23. doi: 10.1093/toxsci/kfp084. Epub 2009 Apr 29.

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Cloning and characterization of hypoxia-inducible factor-1 subunits from Ascaris suum - a parasitic nematode highly adapted to changes of oxygen conditions during its life cycle.

Goto M, Amino H, Nakajima M, Tsuji N, Sakamoto K, Kita K.

Gene. 2013 Mar 1;516(1):39-47. doi: 10.1016/j.gene.2012.12.025. Epub 2012 Dec 23.

PMID:
23268347
8.

A new HIF-1 alpha variant induced by zinc ion suppresses HIF-1-mediated hypoxic responses.

Chun YS, Choi E, Yeo EJ, Lee JH, Kim MS, Park JW.

J Cell Sci. 2001 Nov;114(Pt 22):4051-61.

9.

Metal ions-stimulated iron oxidation in hydroxylases facilitates stabilization of HIF-1 alpha protein.

Kaczmarek M, Cachau RE, Topol IA, Kasprzak KS, Ghio A, Salnikow K.

Toxicol Sci. 2009 Feb;107(2):394-403. doi: 10.1093/toxsci/kfn251. Epub 2008 Dec 13.

10.

NcoA2-Dependent Inhibition of HIF-1α Activation Is Regulated via AhR.

Tsai CH, Li CH, Liao PL, Cheng YW, Lin CH, Huang SH, Kang JJ.

Toxicol Sci. 2015 Dec;148(2):517-30. doi: 10.1093/toxsci/kfv199. Epub 2015 Sep 8.

PMID:
26350169
11.

Intracellular ascorbate enhances hypoxia-inducible factor (HIF)-hydroxylase activity and preferentially suppresses the HIF-1 transcriptional response.

Kuiper C, Dachs GU, Currie MJ, Vissers MC.

Free Radic Biol Med. 2014 Apr;69:308-17. doi: 10.1016/j.freeradbiomed.2014.01.033. Epub 2014 Feb 2.

PMID:
24495550
12.

Hypoxia-inducible factor-1β (HIF-1β) is upregulated in a HIF-1α-dependent manner in 518A2 human melanoma cells under hypoxic conditions.

Mandl M, Kapeller B, Lieber R, Macfelda K.

Biochem Biophys Res Commun. 2013 Apr 26;434(1):166-72. doi: 10.1016/j.bbrc.2013.03.051. Epub 2013 Mar 26.

PMID:
23541582
13.

Hypoxic but not anoxic stabilization of HIF-1alpha requires mitochondrial reactive oxygen species.

Schroedl C, McClintock DS, Budinger GR, Chandel NS.

Am J Physiol Lung Cell Mol Physiol. 2002 Nov;283(5):L922-31.

14.

Targeting the PAS-A domain of HIF-1alpha for development of small molecule inhibitors of HIF-1.

Park EJ, Kong D, Fisher R, Cardellina J, Shoemaker RH, Melillo G.

Cell Cycle. 2006 Aug;5(16):1847-53. Epub 2006 Aug 15.

PMID:
16861921
15.

Ascorbic acid and ascorbate-2-phosphate decrease HIF activity and malignant properties of human melanoma cells.

Miles SL, Fischer AP, Joshi SJ, Niles RM.

BMC Cancer. 2015 Nov 7;15:867. doi: 10.1186/s12885-015-1878-5.

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19.

Nickel-induced transformation shifts the balance between HIF-1 and p53 transcription factors.

Salnikow K, An WG, Melillo G, Blagosklonny MV, Costa M.

Carcinogenesis. 1999 Sep;20(9):1819-23.

PMID:
10469629
20.

Stabilization of hypoxia-inducible factor-1alpha protein in hypoxia occurs independently of mitochondrial reactive oxygen species production.

Chua YL, Dufour E, Dassa EP, Rustin P, Jacobs HT, Taylor CT, Hagen T.

J Biol Chem. 2010 Oct 8;285(41):31277-84. doi: 10.1074/jbc.M110.158485. Epub 2010 Jul 30.

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