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Items: 1 to 20 of 85

1.
2.

Effects of geldanamycin, a heat-shock protein 90-binding agent, on T cell function and T cell nonreceptor protein tyrosine kinases.

Yorgin PD, Hartson SD, Fellah AM, Scroggins BT, Huang W, Katsanis E, Couchman JM, Matts RL, Whitesell L.

J Immunol. 2000 Mar 15;164(6):2915-23.

3.

The Hsp90-specific inhibitor geldanamycin selectively disrupts kinase-mediated signaling events of T-lymphocyte activation.

Schnaider T, Somogyi J, Csermely P, Szamel M.

Cell Stress Chaperones. 2000 Jan;5(1):52-61.

4.

HSP90 protects apoptotic cleavage of vimentin in geldanamycin-induced apoptosis.

Zhang MH, Lee JS, Kim HJ, Jin DI, Kim JI, Lee KJ, Seo JS.

Mol Cell Biochem. 2006 Jan;281(1-2):111-21.

PMID:
16328963
5.
6.
7.

Hsp90 inhibitors, GA and 17AAG, lead to ER stress-induced apoptosis in rat histiocytoma.

Taiyab A, Sreedhar AS, Rao ChM.

Biochem Pharmacol. 2009 Jul 15;78(2):142-52. doi: 10.1016/j.bcp.2009.04.001.

PMID:
19464431
8.

Geldanamycin inhibits tyrosine phosphorylation-dependent NF-kappaB activation.

Crèvecoeur J, Merville MP, Piette J, Gloire G.

Biochem Pharmacol. 2008 Jun 1;75(11):2183-91. doi: 10.1016/j.bcp.2008.03.009.

PMID:
18455150
9.

The heat-shock protein 90 inhibitor, geldanamycin, induces apoptotic cell death in Epstein-Barr virus-positive NK/T-cell lymphoma by Akt down-regulation.

Jeon YK, Park CH, Kim KY, Li YC, Kim J, Kim YA, Paik JH, Park BK, Kim CW, Kim YN.

J Pathol. 2007 Oct;213(2):170-9.

PMID:
17768706
10.

Proteome-wide changes induced by the Hsp90 inhibitor, geldanamycin in anaplastic large cell lymphoma cells.

Schumacher JA, Crockett DK, Elenitoba-Johnson KS, Lim MS.

Proteomics. 2007 Aug;7(15):2603-16.

11.

The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells.

Farina AR, Tacconelli A, Cappabianca L, Cea G, Chioda A, Romanelli A, Pensato S, Pedone C, Gulino A, Mackay AR.

Oncogene. 2009 Nov 19;28(46):4075-94. doi: 10.1038/onc.2009.256.

PMID:
19734938
12.

Heat shock induces apoptosis in mouse thymocytes and protects them from glucocorticoid-induced cell death.

Migliorati G, Nicoletti I, Crocicchio F, Pagliacci C, D'Adamio F, Riccardi C.

Cell Immunol. 1992 Sep;143(2):348-56.

PMID:
1511481
13.

Efficacy of Hsp90 inhibition for induction of apoptosis and inhibition of growth in cervical carcinoma cells in vitro and in vivo.

Schwock J, Pham NA, Cao MP, Hedley DW.

Cancer Chemother Pharmacol. 2008 Apr;61(4):669-81.

PMID:
17579866
14.

Heat shock protein 90 inhibitor induces apoptosis and attenuates activation of hepatic stellate cells.

Myung SJ, Yoon JH, Kim BH, Lee JH, Jung EU, Lee HS.

J Pharmacol Exp Ther. 2009 Jul;330(1):276-82. doi: 10.1124/jpet.109.151860.

15.

Indirect participation of Hsp90 in the regulation of the cyclin E turnover.

Bedin M, Catelli MG, Cabanié L, Gaben AM, Mester J.

Biochem Pharmacol. 2009 Jan 15;77(2):151-8. doi: 10.1016/j.bcp.2008.09.038.

PMID:
18977205
16.

BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90.

Lundgren K, Zhang H, Brekken J, Huser N, Powell RE, Timple N, Busch DJ, Neely L, Sensintaffar JL, Yang YC, McKenzie A, Friedman J, Scannevin R, Kamal A, Hong K, Kasibhatla SR, Boehm MF, Burrows FJ.

Mol Cancer Ther. 2009 Apr;8(4):921-9. doi: 10.1158/1535-7163.MCT-08-0758.

17.
18.

Pharmacological induction of Hsp70 protects apoptosis-prone cells from doxorubicin: comparison with caspase-inhibitor- and cycle-arrest-mediated cytoprotection.

Demidenko ZN, Vivo C, Halicka HD, Li CJ, Bhalla K, Broude EV, Blagosklonny MV.

Cell Death Differ. 2006 Sep;13(9):1434-41.

19.

Genistein induces apoptosis in immature human thymocytes by inhibiting topoisomerase-II.

McCabe MJ Jr, Orrenius S.

Biochem Biophys Res Commun. 1993 Jul 30;194(2):944-50.

PMID:
8393675
20.

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