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Items: 1 to 20 of 549

1.

Design, synthesis, and cytotoxic evaluation of a new series of 3-substituted spiro[(dihydropyrazine-2,5-dione)-6,3'-(2',3'-dihydrothieno[2,3-b]naphtho-4',9'-dione)] derivatives.

Gomez-Monterrey I, Campiglia P, Carotenuto A, Califano D, Pisano C, Vesci L, Lama T, Bertamino A, Sala M, di Bosco AM, Grieco P, Novellino E.

J Med Chem. 2007 Apr 19;50(8):1787-98. Epub 2007 Mar 22.

PMID:
17375902
2.

Synthesis and cytotoxic evaluation of novel spirohydantoin derivatives of the dihydrothieno[2,3-b]naphtho-4,9-dione system.

Gomez-Monterrey I, Santelli G, Campiglia P, Califano D, Falasconi F, Pisano C, Vesci L, Lama T, Grieco P, Novellino E.

J Med Chem. 2005 Feb 24;48(4):1152-7.

PMID:
15715481
3.

Spiro[(dihydropyrazin-2,5-dione)-6,3'-(2',3'-dihydrothieno[2,3-b]naphtho-4',9'-dione)]-based cytotoxic agents: structure-activity relationship studies on the substituent at N4-position of the diketopiperazine domain.

Gomez-Monterrey I, Campiglia P, Carotenuto A, Stiuso P, Bertamino A, Sala M, Aquino C, Grieco P, Morello S, Pinto A, Ianelli P, Novellino E.

J Med Chem. 2008 May 22;51(10):2924-32. doi: 10.1021/jm7013056. Epub 2008 Apr 23.

PMID:
18429610
4.

Antitumor agents. 3. Design, synthesis, and biological evaluation of new pyridoisoquinolindione and dihydrothienoquinolindione derivatives with potent cytotoxic activity.

Bolognese A, Correale G, Manfra M, Lavecchia A, Mazzoni O, Novellino E, La Colla P, Sanna G, Loddo R.

J Med Chem. 2004 Feb 12;47(4):849-58.

PMID:
14761187
5.

Novel angular benzophenazines: dual topoisomerase I and topoisomerase II inhibitors as potential anticancer agents.

Vicker N, Burgess L, Chuckowree IS, Dodd R, Folkes AJ, Hardick DJ, Hancox TC, Miller W, Milton J, Sohal S, Wang S, Wren SP, Charlton PA, Dangerfield W, Liddle C, Mistry P, Stewart AJ, Denny WA.

J Med Chem. 2002 Jan 31;45(3):721-39.

PMID:
11806724
6.

Design, synthesis, and cytotoxic evaluation of acyl derivatives of 3-aminonaphtho[2,3-b]thiophene-4,9-dione, a quinone-based system.

Gomez-Monterrey I, Campiglia P, Aquino C, Bertamino A, Granata I, Carotenuto A, Brancaccio D, Stiuso P, Scognamiglio I, Rusciano MR, Maione AS, Illario M, Grieco P, Maresca B, Novellino E.

J Med Chem. 2011 Jun 23;54(12):4077-91. doi: 10.1021/jm200094h. Epub 2011 May 23.

PMID:
21553829
7.

Structure-activity relationships for substituted bis(acridine-4-carboxamides): a new class of anticancer agents.

Gamage SA, Spicer JA, Atwell GJ, Finlay GJ, Baguley BC, Denny WA.

J Med Chem. 1999 Jul 1;42(13):2383-93.

PMID:
10395479
8.

3-Aminomethyl derivatives of 4,11-dihydroxynaphtho[2,3-f]indole-5,10-dione for circumvention of anticancer drug resistance.

Shchekotikhin AE, Shtil AA, Luzikov YN, Bobrysheva TV, Buyanov VN, Preobrazhenskaya MN.

Bioorg Med Chem. 2005 Mar 15;13(6):2285-91.

PMID:
15727877
10.
11.

New benzo[g]isoquinoline-5,10-diones and dihydrothieno [2,3-b]naphtho-4,9-dione derivatives: synthesis and biological evaluation as potential antitumoral agents.

Gomez-Monterrey I, Campiglia P, Grieco P, Diurno MV, Bolognese A, La Colla P, Novellino E.

Bioorg Med Chem. 2003 Aug 15;11(17):3769-75.

PMID:
12901922
12.

Synthesis, cytotoxicity, DNA interaction, and topoisomerase II inhibition properties of novel indeno[2,1-c]quinolin-7-one and indeno[1,2-c]isoquinolin-5,11-dione derivatives.

Ryckebusch A, Garcin D, Lansiaux A, Goossens JF, Baldeyrou B, Houssin R, Bailly C, Hénichart JP.

J Med Chem. 2008 Jun 26;51(12):3617-29. doi: 10.1021/jm800017u. Epub 2008 May 29.

PMID:
18507368
13.

Synthesis of mono- and bisdihydrodipyridopyrazines and assessment of their DNA binding and cytotoxic properties.

Blanchard S, Rodriguez I, Tardy C, Baldeyrou B, Bailly C, Colson P, Houssier C, Léonce S, Kraus-Berthier L, Pfeiffer B, Renard P, Pierré A, Caubère P, Guillaumet G.

J Med Chem. 2004 Feb 12;47(4):978-87.

PMID:
14761199
14.

Synthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship.

Thapa P, Karki R, Choi H, Choi JH, Yun M, Jeong BS, Jung MJ, Nam JM, Na Y, Cho WJ, Kwon Y, Lee ES.

Bioorg Med Chem. 2010 Mar 15;18(6):2245-54. doi: 10.1016/j.bmc.2010.01.065. Epub 2010 Feb 4.

PMID:
20188578
15.

New isomeric azine-bridged dinuclear platinum(II) complexes circumvent cross-resistance to cisplatin.

Komeda S, Kalayda GV, Lutz M, Spek AL, Yamanaka Y, Sato T, Chikuma M, Reedijk J.

J Med Chem. 2003 Mar 27;46(7):1210-9.

PMID:
12646031
16.

Naphthoindole-based analogues of tryptophan and tryptamine: synthesis and cytotoxic properties.

Shchekotikhin AE, Dezhenkova LG, Susova OY, Glazunova VA, Luzikov YN, Sinkevich YB, Buyanov VN, Shtil AA, Preobrazhenskaya MN.

Bioorg Med Chem. 2007 Apr 1;15(7):2651-9. Epub 2007 Jan 23.

PMID:
17276690
17.

Synthesis and cytotoxic activities of 2-alkyl-2,3-dihydro-1H-2,6,9-triazacyclopenta[b]anthracene-5,10-diones.

Kwak JH, Namgoong K, Jung JK, Cho J, Kim HM, Park SG, Yoo YA, Kwon JH, Lee H.

Arch Pharm Res. 2008 Aug;31(8):995-8. doi: 10.1007/s12272-001-1258-6. Epub 2008 Sep 12. Erratum in: Arch Pharm Res. 2008 Sep;31(9):1224.

PMID:
18787787
18.

Antitumor agents. 234. Design, synthesis, and biological evaluation of novel 4beta-[(4' '-benzamido)-amino]-4'-o-demethyl-epipodophyllotoxin derivatives.

Xiao Z, Bastow KF, Vance JR, Sidwell RS, Wang HK, Chen MS, Shi Q, Lee KH.

J Med Chem. 2004 Oct 7;47(21):5140-8.

PMID:
15456257
19.

Synthesis, cytotoxic activities and proposed mode of binding of a series of bis([(9-oxo-9,10-dihydroacridine-4-carbonyl)amino]alkyl) alkylamines.

Braña MF, Casarrubios L, Domínguez G, Fernández C, Pérez JM, Quiroga AG, Navarro-Ranninger C, de Pascual-Teresa B.

Eur J Med Chem. 2002 Apr;37(4):301-13.

PMID:
11960665
20.

Synthesis and biological evaluation of novel naphthoquinone fused cyclic aminoalkylphosphonates and aminoalkylphosphonic monoester.

Wang B, Miao ZW, Wang J, Chen RY, Zhang XD.

Amino Acids. 2008 Aug;35(2):463-8. Epub 2007 Jul 31.

PMID:
17665273

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