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Items: 1 to 20 of 116

1.

Analogs of the marine alkaloid makaluvamines: synthesis, topoisomerase II inhibition, and anticancer activity.

Shinkre BA, Raisch KP, Fan L, Velu SE.

Bioorg Med Chem Lett. 2007 May 15;17(10):2890-3. Epub 2007 Feb 25.

2.

Synthesis and antiproliferative activity of benzyl and phenethyl analogs of makaluvamines.

Shinkre BA, Raisch KP, Fan L, Velu SE.

Bioorg Med Chem. 2008 Mar 1;16(5):2541-9. Epub 2007 Nov 28.

PMID:
18093835
3.

Design, synthesis and evaluation of new marine alkaloid-derived pentacyclic structures with anti-tumoral potency.

Boucle S, Melin C, Clastre M, Guillard J.

Mar Drugs. 2015 Jan 19;13(1):655-65. doi: 10.3390/md13010655.

4.

Pyrroloquinolinone-based dual topoisomerase I/II inhibitor.

Dalla Via L, Marzaro G, Ferrarese A, Gia O, Chilin A.

Eur J Med Chem. 2014 Apr 22;77:103-9. doi: 10.1016/j.ejmech.2014.02.064. Epub 2014 Mar 1.

PMID:
24631729
5.

In vitro and in vivo anticancer activity of novel synthetic makaluvamine analogues.

Wang W, Rayburn ER, Velu SE, Nadkarni DH, Murugesan S, Zhang R.

Clin Cancer Res. 2009 May 15;15(10):3511-8. doi: 10.1158/1078-0432.CCR-08-2689.

6.

Pyrroloquinoline and pyridoacridine alkaloids from marine sources.

Ding Q, Chichak K, Lown JW.

Curr Med Chem. 1999 Jan;6(1):1-27. Review.

PMID:
9873113
7.

Makaluvamines, marine natural products, are active anti-cancer agents and DNA topo II inhibitors.

Barrows LR, Radisky DC, Copp BR, Swaffar DS, Kramer RA, Warters RL, Ireland CM.

Anticancer Drug Des. 1993 Oct;8(5):333-47.

PMID:
8251041
8.

Amsacrine as a topoisomerase II poison: importance of drug-DNA interactions.

Ketron AC, Denny WA, Graves DE, Osheroff N.

Biochemistry. 2012 Feb 28;51(8):1730-9. doi: 10.1021/bi201159b. Epub 2012 Feb 10.

9.

Characterization of an amsacrine-resistant line of human leukemia cells. Evidence for a drug-resistant form of topoisomerase II.

Zwelling LA, Hinds M, Chan D, Mayes J, Sie KL, Parker E, Silberman L, Radcliffe A, Beran M, Blick M.

J Biol Chem. 1989 Oct 5;264(28):16411-20.

11.

Cross-resistance of an amsacrine-resistant human leukemia line to topoisomerase II reactive DNA intercalating agents. Evidence for two topoisomerase II directed drug actions.

Zwelling LA, Mayes J, Hinds M, Chan D, Altschuler E, Carroll B, Parker E, Deisseroth K, Radcliffe A, Seligman M, et al.

Biochemistry. 1991 Apr 23;30(16):4048-55.

PMID:
1850298
12.

Docking studies, synthesis, characterization of some novel oxazine substituted 9-anilinoacridine derivatives and evaluation for their antioxidant and anticancer activities as topoisomerase II inhibitors.

Kalirajan R, Kulshrestha V, Sankar S, Jubie S.

Eur J Med Chem. 2012 Oct;56:217-24. doi: 10.1016/j.ejmech.2012.08.025. Epub 2012 Aug 31.

PMID:
22982526
13.
14.

Makaluvamines vary in ability to induce dose-dependent DNA cleavage via topoisomerase II interaction.

Matsumoto SS, Haughey HM, Schmehl DM, Venables DA, Ireland CM, Holden JA, Barrows LR.

Anticancer Drugs. 1999 Jan;10(1):39-45.

PMID:
10194546
15.

Makaluvamine N: a new pyrroloiminoquinone from Zyzzya fuliginosa.

Venables DA, ConcepciĆ³n GP, Matsumoto SS, Barrows LR, Ireland CM.

J Nat Prod. 1997 Apr;60(4):408-10.

PMID:
9134749
16.

The 1'-substituent on the anilino ring of the antitumor drug amsacrine is a critical element for topoisomerase II inhibition and cytotoxicity.

Rene B, Fosse P, Khelifa T, Jacquemin-Sablon A, Bailly C.

Mol Pharmacol. 1996 Feb;49(2):343-50.

PMID:
8632768
17.

Antitumor activity of ER-37328, a novel carbazole topoisomerase II inhibitor.

Nakamura K, Sugumi H, Yamaguchi A, Uenaka T, Kotake Y, Okada T, Kamata J, Niijima J, Nagasu T, Koyanagi N, Yoshino H, Kitoh K, Yoshimatsu K.

Mol Cancer Ther. 2002 Jan;1(3):169-75.

20.

Synthesis and antitumor characterization of pyrazolic analogues of the marine pyrroloquinoline alkaloids: wakayin and tsitsikammamines.

Legentil L, Benel L, Bertrand V, Lesur B, Delfourne E.

J Med Chem. 2006 May 18;49(10):2979-88.

PMID:
16686539

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